ArticleThe Journal of clinical endocrinology and metabolism2014
Association of adenovirus 36 infection with adiposity and inflammatory-related markers in children.
Article in The Journal of clinical endocrinology and metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Adenovirus 36 prevalence and association with human obesity: a systematic review.International journal of obesity (2005) · 2021Pooled it
- Article
- Adenovirus 36 Seropositivity Is Related to Inflammation and Imbalance Between Oxidative Stress and Antioxidant Status Regardless of Body Mass Index in Mexican Population.Current issues in molecular biology · 2025Article
- Global Prevalence of Preexisting Antibodies against Human Adenoviruses, Surveyed from 1962 to 2021.Intervirology · 2024Review
- The Impact of Whole Egg Consumption on Bone Accrual in Healthy Children: A Randomized Controlled Trial.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023Article
- Inflammatory cytokines and chemokines in obese adolescents with antibody against to adenovirus 36.Scientific reports · 2023Article
- The Immune Response in Adipocytes and Their Susceptibility to Infection: A Possible Relationship with Infectobesity.International journal of molecular sciences · 2022Review
- Modulating effect of vitamin D status on serum anti-adenovirus 36 antibody amount in children with obesity: National Food and Nutrition Surveillance.BMC pediatrics · 2020Article
- What we know and what we need to know about adenovirus 36-induced obesity.International journal of obesity (2005) · 2020Review
- Ileal transcriptome analysis in obese rats induced by high-fat diets and an adenoviral infection.International journal of obesity (2005) · 2019Article
- Dietary inflammatory index® and cortical bone outcomes in healthy adolescent children.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019Article
- Regulation of PPARγ and CIDEC expression by adenovirus 36 in adipocyte differentiation.Molecular and cellular biochemistry · 2017Article
- Longitudinal investigation of adenovirus 36 seropositivity and human obesity: the Cardiovascular Risk in Young Finns Study.International journal of obesity (2005) · 2015Article
- Adenovirus 36 and Obesity: An Overview.Viruses · 2015Review
- Adenovirus 36 infection and daycare starting age are associated with adiposity in children and adolescents.Jornal de pediatriaArticle
- A microbiological explanation for the obesity pandemic?The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicaleArticle
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
Abstract
contextAlthough animal studies suggest that adenovirus 36 (Ad36) infection is linked to obesity and systemic inflammation, human data are scant and equivocal.
objectiveAssociations of Ad36 infection with total body adiposity and inflammatory-related markers were determined in 291 children aged 9-13 years (50% female, 49% black).
designFasting blood samples were measured for presence of Ad36-specific antibodies and TNF-α, IL-6, vascular endothelial growth factor (VEGF), and monocyte chemoattractant protein-1 (MCP-1). Fat mass and fat-free soft tissue mass were measured by dual-energy X-ray absorptiometry.
resultsThe overall prevalence of Ad36 seropositivity [Ad36(+)] was 42%. There was a higher percentage of Ad36(+) children in the highest tertiles of TNF-α and IL-6 compared with their respective middle and lowest tertiles (both P < .03). There was also a trend toward a higher prevalence of Ad36(+) children in the highest tertile of VEGF compared with tertiles 1 and 2 (P = .05). Multinomial logistic regression, adjusting for age, race, sex, and fat-free soft tissue mass, revealed that compared with children with the lowest TNF-α, IL-6, and VEGF levels (tertile 1), the adjusted odds ratios for Ad36(+) were 2.2 [95% confidence interval (CI) 1.2-4.0], 2.4 (95% CI 1.4-4.0), and 1.8 (95% CI 1.0-3.3), respectively, for those in the highest TNF-α, IL-6, and VEGF levels (tertile 3). No association was observed between Ad36(+) and greater levels of fat mass or MCP-1 (all P > .05).
conclusionsIn children, our data suggest that Ad36(+) may be associated with biomarkers implicated in inflammation but not with greater levels of fat mass.
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