Evidence map›Paper›PMID 24926919›Full record

ArticleEnvironmental research2014

Genetic variation in the CYP1A1 gene is related to circulating PCB118 levels in a population-based sample.

Lars Lind, Johanna Penell, Anne-Christine Syvänen, Tomas Axelsson, Erik Ingelsson, Andrew P Morris, Cecilia Lindgren, Samira Salihovic, Bert van Bavel, P Monica Lind

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Lars LindDepartment of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, Sweden.
Johanna PenellDepartment of Medical Sciences, Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden.
Anne-Christine SyvänenDepartment of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Tomas AxelssonDepartment of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Erik IngelssonDepartment of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Andrew P MorrisWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Cecilia LindgrenWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Samira SalihovicMTM Research Centre, School of Science and Technology, Örebro University, Örebro, Sweden.
Bert van BavelMTM Research Centre, School of Science and Technology, Örebro University, Örebro, Sweden.
P Monica LindDepartment of Medical Sciences, Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden. Electronic address: monica.lind@medsci.uu.se.
Uppsala University · SEÖrebro University · SEUniversity of Oxford · GBCentre for Human Genetics · GB

Funding

Wellcome Trust 081682
6 · The paper itself

Abstract

Several of the polychlorinated biphenyls (PCBs), i.e. the dioxin-like PCBs, are known to induce the P450 enzymes CYP1A1, CYP1A2 and CYP1B1 by activating the aryl hydrocarbon receptor (Ah)-receptor. We evaluated if circulating levels of PCBs in a population sample were related to genetic variation in the genes encoding these CYPs. In the population-based Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study (1016 subjects all aged 70), 21 SNPs in the CYP1A1, CYP1A2 and CYP1B1 genes were genotyped. Sixteen PCB congeners were analysed by high-resolution chromatography coupled to high-resolution mass spectrometry (HRGC/ HRMS). Of the investigated relationships between SNPs in the CYP1A1, CYP1A2 and CYP1B1 and six PCBs (congeners 118, 126, 156, 169, 170 and 206) that captures >80% of the variation of all PCBs measured, only the relationship between CYP1A1 rs2470893 was significantly related to PCB118 levels following strict adjustment for multiple testing (p=0.00011). However, there were several additional SNPs in the CYP1A2 and CYP1B1 that showed nominally significant associations with PCB118 levels (p-values in the 0.003-0.05 range). Further, several SNPs in the CYP1B1 gene were related to both PCB156 and PCB206 with p-values in the 0.005-0.05 range. Very few associations with p<0.05 were seen for PCB126, PCB169 or PCB170. Genetic variation in the CYP1A1 was related to circulating PCB118 levels in the general elderly population. Genetic variation in CYP1A2 and CYP1B1 might also be associated with other PCBs.

Indexed as

Genetic VariationAgedAryl Hydrocarbon HydroxylasesCross-Sectional StudiesCytochrome P-450 CYP1A1Cytochrome P-450 CYP1A2Cytochrome P-450 CYP1B1FemaleGenetic Association StudiesGenotypeHumansMalePolychlorinated BiphenylsPolymorphism, Single Nucleotide2,3',4,4',5-pentachlorobiphenylAryl Hydrocarbon HydroxylasesCYP1A1 protein, humanCYP1A2 protein, humanCYP1B1 protein, humanCytochrome P-450 CYP1A1Cytochrome P-450 CYP1A2Cytochrome P-450 CYP1B1Polychlorinated BiphenylsCYPEpidemiologyGeneMetabolismPCBSNP

Identifiers

PMID24926919
PMCPMC5562272
OpenAlexW1998158440

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.