ArticlePloS one2014
Association of admission serum calcium levels and in-hospital mortality in patients with acute ST-elevated myocardial infarction: an eight-year, single-center study in China.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 46 citations in OpenAlex.
- Low serum calcium is associated with higher long-term mortality in myocardial infarction patients from a population-based registry.Scientific reports · 2021Trial
- Association of serum calcium levels with cardiac arrest risk in heart failure patients from the eICU database.Scientific reports · 2026Article
- The correlation between serum calcium and asprosin in elderly patients with type 2 diabetes mellitus in community.Frontiers in endocrinology · 2026Article
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- Article
- Association between serum calcium level and the risk of acute kidney injury in patients with acute myocardial infarction: evidences from the MIMIC-IV database.Renal failure · 2024Article
- Association between serum calcium and in-hospital mortality in critically ill atrial fibrillation patients from the MIMIC IV database.Scientific reports · 2024Article
- Serum calcium is associated with sudden cardiac arrest in stroke patients from ICU: a multicenter retrospective study based on the eICU collaborative research database.Scientific reports · 2024Article
- Propensity score analysis of red cell distribution width to serum calcium ratio in acute myocardial infarction as a predictor of in-hospital mortality.Frontiers in cardiovascular medicine · 2023Article
- Association between serum calcium level and in-hospital mortality in patients with acute myocardial infarction: a retrospective cohort study.Scientific reports · 2022Article
- The synergy between diurnal temperature range and calcium concentration help to predict hospital mortality in patients with acute myocardial infarction.Scientific reports · 2022Article
- Development and Validation of a Personalized Model With Transfer Learning for Acute Kidney Injury Risk Estimation Using Electronic Health Records.JAMA network open · 2022Article
- Association between serum calcium levels and first stroke: A community-based nested case-control study.Frontiers in neurology · 2022Article
- Higher serum phosphorus and calcium levels provide prognostic value in patients with acute myocardial infarction.Frontiers in cardiovascular medicine · 2022Article
- Observational
- The Prognostic Value of Calcium in Post-Cardiovascular Surgery Patients in the Intensive Care Unit.Frontiers in cardiovascular medicine · 2021Article
- Admission Serum Ionized and Total Calcium as New Predictors of Mortality in Patients with Cardiogenic Shock.BioMed research international · 2021Article
- Association between serum calcium and prognosis in patients with acute pulmonary embolism and the optimization of pulmonary embolism severity index.Respiratory research · 2020Observational
- Association between Serum Calcium and First Incident Acute Myocardial Infarction: A Cross-Sectional Study.Iranian journal of public health · 2020Article
- Impact of Changes in Serum Calcium Levels on In-Hospital Mortality.Medicina (Kaunas, Lithuania) · 2020Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe relationship between admission serum calcium levels and in-hospital mortality in patients with acute ST-segment elevation myocardial infarction (STEMI) has not been well definitively explored. The objective was to assess the predictive value of serum calcium levels on in-hospital mortality in STEMI patients.
methodsFrom 2003 to 2010, 1431 consecutive STEMI patients admitted to the First Affiliated Hospital of Nanjing Medical University were enrolled in the present study. Patients were stratified according to quartiles of serum calcium from the blood samples collected in the emergency room after admission. Between the aforementioned groups,the baseline characteristics, in-hospital management, and in-hospital mortality were analyzed. The association of serum calcium level with in-hospital mortality was calculated by a multivariable Cox regression analysis.
resultsAmong 1431 included patients, 79% were male and the median age was 65 years (range, 55-74). Patients in the lower quartiles of serum calcium, as compared to the upper quartiles of serum calcium, were older, had more cardiovascular risk factors, lower rate of emergency revascularization,and higher in-hospital mortality. According to univariate Cox proportional analysis, patients with lower serum calcium level (hazard ratio 0.267, 95% confidence interval 0.164-0.433, p<0.001) was associated with higher in-hospital mortality. The result of multivariable Cox proportional hazard regression analyses showed that the Killip's class≥3 (HR = 2.192, p = 0.026), aspartate aminotransferase (HR = 1.001, p<0.001), neutrophil count (HR = 1.123, p<0.001), serum calcium level (HR = 0.255, p = 0.001), and emergency revascularization (HR = 0.122, p<0.001) were significantly and independently associated with in-hospital mortality in STEMI patients.
conclusionsSerum calcium was an independent predictor for in-hospital mortality in patients with STEMI. This widely available serum biochemical index may be incorporated into the current established risk stratification model of STEMI patients. Further studies are required to determine the actual mechanism and whether patients with hypocalcaemia could benefit from calcium supplement.
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