ArticleExperimental and therapeutic medicine2014
Amelioration of insulin resistance in rat cells by Astragalus polysaccharides and associated mechanisms.
Article in Experimental and therapeutic medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Research Progress on Chemical Components ofMolecules (Basel, Switzerland) · 2025Review
- Astragalus polysaccharides: structure-immunomodulation relationships, multi-target pharmacological activities, and cutting-edge applications in immune modulation.Frontiers in immunology · 2025Review
- The natural compound, formononetin, extracted from Astragalus membranaceus increases adipocyte thermogenesis by modulating PPARγ activity.British journal of pharmacology · 2018Article
- Astragalus membranaceus-Polysaccharides Ameliorates Obesity, Hepatic Steatosis, Neuroinflammation and Cognition Impairment without Affecting Amyloid Deposition in Metabolically Stressed APPswe/PS1dE9 Mice.International journal of molecular sciences · 2017Article
- System Pharmacology-Based Dissection of the Synergistic Mechanism of Huangqi and Huanglian for Diabetes Mellitus.Frontiers in pharmacology · 2017Article
- Astragalus polysaccharide suppresses palmitate-induced apoptosis in human cardiac myocytes: the role of Nrf1 and antioxidant response.International journal of clinical and experimental pathology · 2015Article
- Notch1/3 and p53/p21 are a potential therapeutic target for APS-induced apoptosis in non-small cell lung carcinoma cell lines.International journal of clinical and experimental medicine · 2015Article
- Qizhi Jiangtang Jiaonang Improves Insulin Signaling and Reduces Inflammatory Cytokine Secretion and Reactive Oxygen Species Formation in Insulin Resistant HepG2 Cells.Evidence-based complementary and alternative medicine : eCAM · 2015Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate the function of Astragalus polysaccharides (APS) in ameliorating insulin resistance (IR) in rat cells and to elucidate the associated mechanisms. Fully differentiated, induced 3T3-L1 rat adipocytes were divided into a control group and three intervention groups. The intervention groups were incubated in media containing 0.001, 0.1 and 10 μg/μl APS, respectively, for 48 h. Following treatment, levels of interleukin (IL)-6 and adiponectin secreted by the cultured adipocytes were measured using enzyme-linked immunosorbent assay. Levels of adiponectin secreted by the 3T3-L1 adipocytes in the moderate-concentration intervention group were significantly increased compared with those in the control group (P<0.05), whereas levels of adiponectin secreted by the 3T3-L1 adipocytes in the low- and high-concentration intervention groups were decreased compared with those in the control group (P<0.05 and P>0.05, respectively). Levels of IL-6 secreted by the 3T3-L1 adipocytes in the three intervention groups were lower than those in the control group (P>0.05, P<0.05 and P<0.05 for the low- moderate- and high-concentration intervention groups, respectively), and demonstrated APS dose-dependence. The results indicate that APS are capable of increasing adiponectin secretion and reducing IL-6 secretion by 3T3-L1 rat adipocytes in a dose-dependent manner. These findings may identify a potential mechanism for ameliorating IR using APS.
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