ArticleFrontiers in plant science2014
Mitogen-activated protein kinase signal transduction and DNA repair network are involved in aluminum-induced DNA damage and adaptive response in root cells of Allium cepa L.
Article in Frontiers in plant science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- Aluminum Genotoxicity in Plants, Mammals, and Unicellular Eukaryotes: The Underlying Mechanisms.International journal of molecular sciences · 2026Review
- Evaluation of Clastogenic and Aneugenic Action of Two Bio-Insecticides Using Allium Bioassay.Journal of xenobiotics · 2025Article
- Article
- Evaluating the genotoxicity of salinity stress and secondary products gene manipulation in lime,Frontiers in plant science · 2023Article
- Genome Wide Association Mapping of Root Traits in the Andean Genepool of Common Bean (Frontiers in plant science · 2021Article
- Deconstructing the genetic architecture of iron deficiency chlorosis in soybean using genome-wide approaches.BMC plant biology · 2020Article
- Dissection of Root Transcriptional Responses to Low pH, Aluminum Toxicity and Iron Excess Under Pi-Limiting Conditions in Arabidopsis Wild-Type andFrontiers in plant science · 2020Article
- Cytotoxicity and genotoxicity of Guaribas river water (Piauí, Brazil), influenced by anthropogenic action.Environmental monitoring and assessment · 2017Article
- MAPK-mediated auxin signal transduction pathways regulate the malic acid secretion under aluminum stress in wheat (Triticum aestivum L.).Scientific reports · 2017Article
- The use of comet assay in plant toxicology: recent advances.Frontiers in genetics · 2015Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
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Abstract
In the current study, we studied the role of signal transduction in aluminum (Al(3+))-induced DNA damage and adaptive response in root cells of Allium cepa L. The root cells in planta were treated with Al(3+) (800 μM) for 3 h without or with 2 h pre-treatment of inhibitors of mitogen-activated protein kinase (MAPK), and protein phosphatase. Also, root cells in planta were conditioned with Al(3+) (10 μM) for 2 h and then subjected to genotoxic challenge of ethyl methane sulfonate (EMS; 5 mM) for 3 h without or with the pre-treatment of the aforementioned inhibitors as well as the inhibitors of translation, transcription, DNA replication and repair. At the end of treatments, roots cells were assayed for cell death and/or DNA damage. The results revealed that Al(3+) (800 μM)-induced significant DNA damage and cell death. On the other hand, conditioning with low dose of Al(3+) induced adaptive response conferring protection of root cells from genotoxic stress caused by EMS-challenge. Pre-treatment of roots cells with the chosen inhibitors prior to Al(3+)-conditioning prevented or reduced the adaptive response to EMS genotoxicity. The results of this study suggested the involvement of MAPK and DNA repair network underlying Al-induced DNA damage and adaptive response to genotoxic stress in root cells of A. cepa.
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