ReviewFrontiers in pharmacology2014
Iron, hepcidin, and the metal connection.
Review in Frontiers in pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05718752 (Characterization of the Metallome Fingerprint to Acute Intense Exercise), which is not on this map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Characterization of the Metallome Fingerprint to Acute Intense Exercise: a Pilot Study on 40 Healthy Men and Women.
Who cites it
26 citing papers in PubMed.
- Serum Copper-to-Zinc Ratio and Oxidative Stress Are Associated with Anemia in Older Adults with Cardiovascular-Kidney-Metabolic Syndrome.International journal of molecular sciences · 2026Article
- Iron Metabolism, Calcium, Magnesium and Trace Elements: A Review.Biological trace element research · 2025Review
- Systematic analysis of copper, zinc, and selenium levels in JAK2 V617F-positive myeloproliferative neoplasms.Annals of hematology · 2024Article
- The effects of intracellular iron availability on the outcome ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2023Article
- Bloodlettings in Hemochromatosis Result in Increased Blood Lead (Pb) Concentrations.Biological trace element research · 2023Article
- Dietary iron affects lipid deposition, nutritional element, and muscle quality in coho salmon (Food chemistry: X · 2022Article
- Article
- Direct Cell Radiolabeling forChemical reviews · 2022Review
- Taurine Ameliorates Iron Overload-Induced Hepatocyte Injury via the Bcl-2/VDAC1-Mediated Mitochondrial Apoptosis Pathway.Oxidative medicine and cellular longevity · 2022Article
- circSnx12 Is Involved in Ferroptosis During Heart Failure by Targeting miR-224-5p.Frontiers in cardiovascular medicine · 2021Article
- Ferroptosis Is a Potential Novel Diagnostic and Therapeutic Target for Patients With Cardiomyopathy.Frontiers in cell and developmental biology · 2021Review
- The Role of Fe, Zn, and Cu in Pregnancy.Biomolecules · 2020Review
- TfR1 Extensively Regulates the Expression of Genes Associated with Ion Transport and Immunity.Current medical science · 2020Article
- p53 tumor suppressor and iron homeostasis.The FEBS journal · 2019Review
- Metal-dependent hormone function: the emerging interdisciplinary field of metalloendocrinology.Metallomics : integrated biometal science · 2019Review
- Innate Nutritional Immunity.Journal of immunology (Baltimore, Md. : 1950) · 2018Review
- The crucial impact of iron deficiency definition for the course of precapillary pulmonary hypertension.PloS one · 2018Article
- Hemochromatosis: a model of metal-related human toxicosis.Environmental science and pollution research international · 2018Article
- The Relevance of Iron in the Pathogenesis of Multiple System Atrophy: A Viewpoint.Journal of Alzheimer's disease : JAD · 2018Review
- Studying disorders of vertebrate iron and heme metabolism using zebrafish.Methods in cell biology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Identification of new players in iron metabolism, such as hepcidin, which regulates ferroportin and divalent metal transporter 1 expression, has improved our knowledge of iron metabolism and iron-related diseases. However, from both experimental data and clinical findings, "iron-related proteins" appear to also be involved in the metabolism of other metals, especially divalent cations. Reports have demonstrated that some metals may affect, directly or indirectly, the expression of proteins involved in iron metabolism. Throughout their lives, individuals are exposed to various metals during personal and/or occupational activities. Therefore, better knowledge of the connections between iron and other metals could improve our understanding of iron-related diseases, especially the variability in phenotypic expression, as well as a variety of diseases in which iron metabolism is secondarily affected. Controlling the metabolism of other metals could represent a promising innovative therapeutic approach.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.