ArticleScience (New York, N.Y.)2014
Human genetics. The genetics of Mexico recapitulates Native American substructure and affects biomedical traits.
Registry-linked trialAbstract read
In one paragraph
Article in Science (New York, N.Y.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04915638 (Evaluation of Nutritional Status in Chimalhuacán Children), which is not on this map. Cited by 242 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
242citing papers in PubMed, 3 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Nutritional Status in Chimalhuacán Children: Anthropometric, Biochemical, and Molecular Approaches
Who cites it
242 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Genetic variants associated with idiopathic Parkinson's disease in Latin America: A systematic review.Neurogenetics · 2025Pooled it
- Spatiotemporal fluctuations of population structure in the Americas revealed by a meta-analysis of the first decade of archaeogenomes.American journal of biological anthropology · 2023Pooled it
- An admixture mapping meta-analysis implicates genetic variation at 18q21 with asthma susceptibility in Latinos.The Journal of allergy and clinical immunology · 2019Pooled it
- Whole genome variation in 27 Mexican indigenous populations, demographic and biomedical insights.PloS one · 2021Trial
- Trial
- Association of Native American, European, and African Ancestry with CYP450 Pharmacogenetics and Metabolic Phenotypes in Admixed Latin American Populations from Ecuador and Nicaragua.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Whole genome sequencing of 1427 Mexican individuals from the oriGen cohort.Nature communications · 2026Article
- Extending genome-wide association studies to admixed cohorts with high degrees of relatedness.Nature genetics · 2026Article
- Identification and Computational Analysis ofMedical sciences (Basel, Switzerland) · 2026Article
- Genetic Diversity Analysis of Risk Variants Associated with Bone and Cartilage Metabolism in Nine Mexican Subpopulations.Biomedicines · 2026Article
- PTGDR -441 C/T Polymorphism in a Mexican Mestizo Population with Inflammatory Myopathies: A Pilot Study.Current issues in molecular biology · 2026Article
- Demographic History of Indigenous Populations in Mexico Explored Through Whole Mitogenome Analysis.Genome biology and evolution · 2026Article
- Regulatory Variation at TERT and TERC Shows Limited Association with Early-Onset Alzheimer's Disease in Carriers of the Mexican Founder MutationMedical sciences (Basel, Switzerland) · 2026Article
- Deleterious coding variation associated with autism is shared across ancestries.Nature medicine · 2026Article
- Performance of the ForenSeqGenes · 2026Article
- Article
- Clinical genetic variation across Hispanic populations in the Mexican Biobank.Nature medicine · 2026Article
- Maternal lineage diversity based on mitochondrial DNA in a population sample from Mexico City.Molecular biology reports · 2025Article
- Genetic and genomic insights of the Comcáac people.Journal of community genetics · 2025Review
- Admixture Mapping of Lipid Traits in Hispanic Americans.Journal of the American Heart Association · 2025Article
182 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
40 authors.
Andrés Moreno-EstradaDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA. cdbustam@stanford.edu morenoe@stanford.edu esteban.burchard@ucsf.edu.
Christopher R GignouxDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA. cdbustam@stanford.edu morenoe@stanford.edu esteban.burchard@ucsf.edu.
Juan Carlos Fernández-LópezInstituto Nacional de Medicina Genómica (INMEGEN), Mexico City, Mexico.
Fouad ZakhariaDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Martin SikoraDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Alejandra V ContrerasInstituto Nacional de Medicina Genómica (INMEGEN), Mexico City, Mexico.
Victor Acuña-AlonzoEscuela Nacional de Antropología e Historia (ENAH), Mexico City, Mexico. Department of Genetics, Evolution and Environment, University College London, London, UK.
Karla SandovalDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Celeste EngDepartment of Medicine, University of California, San Francisco, CA, USA.
Sandra Romero-HidalgoInstituto Nacional de Medicina Genómica (INMEGEN), Mexico City, Mexico.
Patricia Ortiz-TelloDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Victoria RoblesDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Eimear E KennyDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Ismael Nuño-AranaInstituto de Investigación en Genética Molecular, Universidad de Guadalajara, Ocotlán, Mexico.
Rodrigo Barquera-LozanoEscuela Nacional de Antropología e Historia (ENAH), Mexico City, Mexico.
Gastón Macín-PérezEscuela Nacional de Antropología e Historia (ENAH), Mexico City, Mexico.
Julio Granados-ArriolaInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Scott HuntsmanDepartment of Medicine, University of California, San Francisco, CA, USA.
Joshua M GalanterDepartment of Medicine, University of California, San Francisco, CA, USA. Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA.
Marc ViaDepartment of Medicine, University of California, San Francisco, CA, USA.
Jean G FordThe Brooklyn Hospital Center, Brooklyn, NY, USA.
Rocío ChapelaInstituto Nacional de Enfermedades Respiratorias (INER), Mexico City, Mexico.
William Rodriguez-CintronVeterans Caribbean Health Care System, San Juan, Puerto Rico.
Jose R Rodríguez-SantanaDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA. Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City, Mexico.
Isabelle RomieuInternational Agency for Research on Cancer, Lyon, France.
Juan José Sienra-MongeHospital Infantil de México Federico Gomez, Mexico City, Mexico.
Blanca del Rio NavarroHospital Infantil de México Federico Gomez, Mexico City, Mexico.
Stephanie J LondonNational Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.
Andrés Ruiz-LinaresDepartment of Genetics, Evolution and Environment, University College London, London, UK.
Rodrigo Garcia-HerreraInstituto Nacional de Medicina Genómica (INMEGEN), Mexico City, Mexico.
Karol EstradaInstituto Nacional de Medicina Genómica (INMEGEN), Mexico City, Mexico.
Alfredo Hidalgo-MirandaInstituto Nacional de Medicina Genómica (INMEGEN), Mexico City, Mexico.
Gerardo Jimenez-SanchezInstituto Nacional de Medicina Genómica (INMEGEN), Mexico City, Mexico.
Alessandra CarnevaleInstituto Nacional de Medicina Genómica (INMEGEN), Mexico City, Mexico.
Xavier SoberónInstituto Nacional de Medicina Genómica (INMEGEN), Mexico City, Mexico.
Samuel Canizales-QuinterosInstituto Nacional de Medicina Genómica (INMEGEN), Mexico City, Mexico. Facultad de Química, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Héctor Rangel-VillalobosInstituto de Investigación en Genética Molecular, Universidad de Guadalajara, Ocotlán, Mexico.
Irma Silva-ZolezziInstituto Nacional de Medicina Genómica (INMEGEN), Mexico City, Mexico.
Esteban Gonzalez BurchardDepartment of Medicine, University of California, San Francisco, CA, USA. Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA. cdbustam@stanford.edu morenoe@stanford.edu esteban.burchard@ucsf.edu.
Carlos D BustamanteDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA. cdbustam@stanford.edu morenoe@stanford.edu esteban.burchard@ucsf.edu.
Funding
INSTITUTIONAL TRAINING GRANT IN GENOME SCIENCET32HG000044 · NHGRI · STANFORD UNIVERSITY · PI MICHAEL P. SNYDER · 1995 to 2026
$32.2MPHARMACOGENETICS OF MEMBRANE TRANSPORTERSU01GM061390 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GIACOMINI, KATHLEEN M · 2000 to 2009
$29.2MWELFARE REFORM AND THE PERINATAL HEALTH OF IMMIGRANTSM01RR000083 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KESSLER, DAVID A · 1985 to 2006
$21.1MPharmacogenomics of Membrane TransportersU19GM061390 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WITTE, JOHN S. · 2010 to 2014
$16.3MCLINICAL, PHARMACOLOGY, DRUG ACTION &PHARMACOKINETICST32GM007546 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Radojka Savic · 1985 to 2026
$8.9MPHARMACEUTICAL SCIENCES AND PHARMACOGENOMICST32GM007175 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV, KROETZ, DEANNA L · 1985 to 2021
$7.1MGenetic And Environmental Factors In Childhood Respiratory HealthZIAES049019 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LONDON, STEPHANIE · 2009 to 2025
$6.8MSocial Interventions to address disparities In young adult tobacco useP60MD006902 · NIMHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BIBBINS-DOMINGO, KIRSTEN · 2012 to 2016
$6.4MGenetics and Environment in Adult Respiratory, Allergic and Cardiac diseaseZIAES043012 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LONDON, STEPHANIE · 2009 to 2025
$6.4MGene-environments and Admixture in Latino Asthmatics (GALA 2)R01ES015794 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ · 2008 to 2012
$5.4MPopulation Genetic Inferences From Dense Genotype DataR01HG003229 · NHGRI · CORNELL UNIVERSITY ITHACA · PI BUSTAMANTE, CARLOS DANIEL, CLARK, ANDREW G · 2004 to 2013
$4.8MWhole Genome Analyses for Asthma in Latino PopulationsR01HL088133 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ · 2008 to 2012
$3.8MBiotechnology and Biological Sciences Research Council BB/I021213/1Intramural NIH HHS Z01 ES049019Intramural NIH HHS ZIA ES049019NCRR NIH HHS M01 RR000083NCRR NIH HHS RR000083NHGRI NIH HHS R01 HG003229NHGRI NIH HHS R01HG003229NHGRI NIH HHS T32 HG000044NHGRI NIH HHS T32HG000044NHLBI NIH HHS HL004464NHLBI NIH HHS HL078885NHLBI NIH HHS HL088133NHLBI NIH HHS HL111636NHLBI NIH HHS K23 HL004464NHLBI NIH HHS K23 HL111636NHLBI NIH HHS R01 HL078885NHLBI NIH HHS R01 HL088133NIEHS NIH HHS ES015794NIEHS NIH HHS R01 ES015794NIEHS NIH HHS ZIA ES49019NIGMS NIH HHS GM007546NIGMS NIH HHS GM061390NIGMS NIH HHS R01 GM083606NIGMS NIH HHS R01 GM090087NIGMS NIH HHS R01GM090087NIGMS NIH HHS T32 GM007175NIGMS NIH HHS T32GM007175NIGMS NIH HHS T32 GM007546NIGMS NIH HHS U01 GM061390NIGMS NIH HHS U19 GM061390NIMHD NIH HHS P60 MD006902NIMHD NIH HHS P60MD006902NIMHD NIH HHS R13 MD008154World Health Organization 001
Abstract
Mexico harbors great cultural and ethnic diversity, yet fine-scale patterns of human genome-wide variation from this region remain largely uncharacterized. We studied genomic variation within Mexico from over 1000 individuals representing 20 indigenous and 11 mestizo populations. We found striking genetic stratification among indigenous populations within Mexico at varying degrees of geographic isolation. Some groups were as differentiated as Europeans are from East Asians. Pre-Columbian genetic substructure is recapitulated in the indigenous ancestry of admixed mestizo individuals across the country. Furthermore, two independently phenotyped cohorts of Mexicans and Mexican Americans showed a significant association between subcontinental ancestry and lung function. Thus, accounting for fine-scale ancestry patterns is critical for medical and population genetic studies within Mexico, in Mexican-descent populations, and likely in many other populations worldwide.
Indexed as
Genetic VariationBlack PeopleGenome, HumanHumansIndians, North AmericanMexican AmericansMexicoPopulationWhite People
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Read underepoch 390
Registered trials
NCT04915638ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.