Evidence map›Paper›PMID 24925692›Full record

SynthesisSeminars in arthritis and rheumatism2014

Health Assessment Questionnaire disability progression in early rheumatoid arthritis: systematic review and analysis of two inception cohorts.

Sam Norton, Bo Fu, David L Scott, Chris Deighton, Deborah P M Symmons, Allan J Wailoo, Jonathan Tosh, Mark Lunt, Rebecca Davies, Adam Young and 1 more

Open access · hybridAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Seminars in arthritis and rheumatism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 2 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 77 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Sam NortonPsychology Department, Institute of Psychiatry, King׳s College London, London, UK.
Bo FuCentre for Biostatistics, Institute of Population Health, The University of Manchester, Manchester, UK.
David L ScottDepartment of Rheumatology, Kings College Hospital, London, UK.
Chris DeightonDepartment of Rheumatology, Medical Specialities Out-Patients, Rehabilitation Block, Royal Derby Hospital, Derby, UK.
Deborah P M SymmonsArthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, The University of Manchester, Manchester Academic Health Science Centre, Stopford Building, Oxford Rd, Manchester M13 9PT, UK; NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust and University of Manchester Partnership, Manchester, UK.
Allan J WailooSchool of Health and Related Research, University of Sheffield, UK.
Jonathan ToshSchool of Health and Related Research, University of Sheffield, UK.
Mark LuntArthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, The University of Manchester, Manchester Academic Health Science Centre, Stopford Building, Oxford Rd, Manchester M13 9PT, UK.
Rebecca DaviesArthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, The University of Manchester, Manchester Academic Health Science Centre, Stopford Building, Oxford Rd, Manchester M13 9PT, UK.
Adam YoungEarly Rheumatoid Arthritis Study, City Hospital, St Albans, UK.
Suzanne M M VerstappenArthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, The University of Manchester, Manchester Academic Health Science Centre, Stopford Building, Oxford Rd, Manchester M13 9PT, UK. Electronic address: Suzanne.Verstappen@manchester.ac.uk.
University of Manchester · GBManchester Academic Health Science Centre · GBUniversity of Sheffield · GBKing's College Hospital · GBKing's College London · GBRoyal Derby Hospital · GBSt Albans City Hospital · GB

Funding

Arthritis Research UK 17552Arthritis Research UK 20380Department of Health MANMKBRU-2012-1
6 · The paper itself

Abstract

objectiveThe Health Assessment Questionnaire is widely used for patients with inflammatory polyarthritis (IP) and its subset, rheumatoid arthritis (RA). In this study, we evaluated the progression of HAQ scores in RA (i) by systematically reviewing the published literature on the methods used to assess changes in functional disability over time and (ii) to study in detail HAQ progression in two large prospective observational studies from the UK.

methodsData from two large inception cohorts, ERAS and NOAR, were studied to determine trajectories of HAQ progression over time by applying latent class growth models (LCGMs) to each dataset separately. Age, sex, baseline DAS28, symptom duration, rheumatoid factor, fulfilment of the 1987 ACR criteria and socio-economic status (SES) were included as potential predictors of HAQ trajectory subgroup membership.

resultsThe literature search identified 49 studies showing that HAQ progression has mainly been based on average changes in the total study population. In the HAQ progression study, a LCGM with four HAQ trajectory subgroups was selected as providing the best fit in both cohorts. In both the cohorts, older age, female sex, longer symptom duration, fulfilment of the 1987 ACR criteria, higher DAS28 and lower SES were associated with increased likelihood of membership of subgroups with worse HAQ progression.

conclusionFour distinct HAQ trajectory subgroups were derived from the ERAS and NOAR cohorts. The fact that the subgroups identified were nearly identical supports their validity. Identifying distinct groups of patients who are at risk of poor functional outcome may help to target therapy to those who are most likely to benefit.

Indexed as

Disability EvaluationDisease ProgressionPatient Outcome AssessmentSurveys and QuestionnairesAdolescentAdultAgedAged, 80 and overAntirheumatic AgentsArthritis, RheumatoidBiological ProductsCohort StudiesFemaleHumansMaleMethotrexateAntirheumatic AgentsBiological ProductsMethotrexateHealth Assessment QuestionnaireInflammatory polyarthritisLatent class growth modelPredictorsRheumatoid arthritisSystematic review

Identifiers

PMID24925692
PMCPMC4282305
OpenAlexW2108897503

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.