ArticleBone2014
Three-dimensional analysis of subchondral cysts in hip osteoarthritis: an ex vivo HR-pQCT study.
Article in Bone, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- Review
- Cystic lesions in osteoarthritis and osteonecrosis of the femoral head : a comparative analysis of 3D distribution, microstructure, and histology.Bone & joint research · 2025Article
- Osteoarthritis of the sternoclavicular joint: is clavicular length a risk factor?Archives of orthopaedic and trauma surgery · 2025Article
- Article
- Deciphering the shared genetic structure between hip osteoarthritis and femoral neck bone mineral density.Frontiers in genetics · 2025Article
- Investigating the utility of HR-pQCT for the assessment of joint space and bone mineral density in hand osteoarthritis.Osteoarthritis imaging · 2024Article
- Subchondral Bone Cyst Development in Osteoarthritis: From Pathophysiology to Bone Microarchitecture Changes and Clinical Implementations.Journal of clinical medicine · 2023Review
- Comparison of clinical-CT segmentation techniques for measuring subchondral bone cyst volume in glenohumeral osteoarthritis.Journal of experimental orthopaedics · 2023Article
- Structural features of subchondral bone cysts and adjacent tissues in hip osteoarthritis.Osteoarthritis and cartilage · 2022Article
- Spatial assessment of femoral neck bone density and microstructure in hip osteoarthritis.Bone reports · 2022Article
- Cyst formation in the subchondral bone following cartilage repair.Clinical and translational medicine · 2020Review
- Differences in subchondral trabecular bone microstructure and finite element analysis-based biomechanical properties between osteoporosis and osteoarthritis.Journal of orthopaedic translation · 2020Article
- Bone marrow lesions: etiology and pathogenesis at the hip.Journal of hip preservation surgery · 2020Review
- Knee osteoarthritis patients with more subchondral cysts have altered tibial subchondral bone mineral density.BMC musculoskeletal disorders · 2019Article
- Radiological analysis of cystic lesion in osteonecrosis of the femoral head.International orthopaedics · 2018Observational
- Longitudinal morphological change of acetabular subchondral bone cyst after total hip arthroplasty in developmental dysplasia of the hip.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2018Article
- Proximal tibial trabecular bone mineral density is related to pain in patients with osteoarthritis.Arthritis research & therapy · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
introductionSubchondral cysts are deeply related to the pathogenesis of osteoarthritis (OA), but the factors contributing to cyst formation are not well known. A three-dimensional analysis of subchondral cysts at the micro-structural level was conducted using a high-resolution peripheral quantitative CT (HR-pQCT), and their relationships with cartilage attrition and subchondral bone microstructure were investigated.
methodsFemoral heads extracted from ten female patients with hip OA were scanned using an HR-pQCT at a voxel size of 41μm. The volume fractions, numbers, and sizes of the cysts were measured in the subchondral bone region under the area of cartilage loss. Furthermore, the areas of cartilage loss, as well as the microstructure of the subchondral bones, were also measured, and their correlations with the cysts were analyzed.
resultsThe volume fractions of cysts within subchondral bone regions varied from 2% to 33%, the numbers of cysts varied from 6 to 87, and the sizes varied from 1mm(3) to 657mm(3). There was a positive correlation between the number of cysts and bone volume (r>0.8, p<0.01).
conclusionThe degree of cyst formation showed a wide distribution in number and volume, and there was a close relationship between multiple cyst formation and bone sclerosis, which might be caused by reactive bone formation that occurred around each cyst.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.