Evidence map›Paper›PMID 24925205›Full record

ArticleJournal of negative results in biomedicine2014

Lack of association between serotonin transporter 5-HTT gene polymorphism and endometriosis in an Italian patient population.

Francesca Megiorni, Serena Resta, Deliar Yazdanian, Gabriele Cavaggioni, Claudia Lia, Pierluigi Benedetti Panici, Antonio Pizzuti, Maria Grazia Porpora

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of negative results in biomedicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Diagnostics (Basel, Switzerland) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Francesca MegiorniDepartment of Experimental Medicine, Policlinico Umberto I, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy. francesca.megiorni@uniroma1.it.
Serena Resta
Deliar Yazdanian
Gabriele Cavaggioni
Claudia Lia
Pierluigi Benedetti Panici
Antonio Pizzuti
Maria Grazia Porpora
Policlinico Umberto I · ITSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this study was to determine whether the serotonin transporter gene (5-HTT), a key component in the control of the serotonergic system, is associated with endometriosis in an Italian population.

findingsA case-control study, comprising 137 Italian patients with surgically confirmed endometriosis and 120 healthy controls, was carried out. 5-HTT genotypes (LL, SL and SS) were obtained by polymerase chain reaction and gel electrophoresis analysis. We found no overall difference in genotypic and allelic distributions of the 5-HTT gene between cases and controls.

conclusionsOur results suggest that the 5-HTT L/S promoter polymorphism is not associated with susceptibility to endometriosis in the studied Italian patients.

Indexed as

AdultCase-Control StudiesEndometriosisFemaleGenetic Association StudiesHumansMiddle AgedPolymorphism, GeneticPopulation SurveillancePromoter Regions, GeneticSerotonin Plasma Membrane Transport ProteinsSerotonin Plasma Membrane Transport ProteinsSLC6A4 protein, human

Identifiers

PMID24925205
PMCPMC4066692
OpenAlexW2161461113

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.