ArticleEuropean journal of clinical pharmacology2014
Potentially inappropriate medications and adverse drug reactions in the elderly: a study in a PharmacoVigilance database.
Article in European journal of clinical pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Medication review in older adults at hospital discharge: an analysis of data from the IATROPREV study.European geriatric medicine · 2026Observational
- Potential inappropriate medications and drug-drug interactions in adverse drug reactions in the elderly: a retrospective study in a pharmacovigilance database.Frontiers in pharmacology · 2025Article
- Opportunities and challenges of pharmacovigilance in special populations: a narrative review of the literature.Therapeutic advances in drug safety · 2023Review
- Adverse Drug Reactions and Potentially Inappropriate Medication in Older Patients: Analysis of the Portuguese Pharmacovigilance Database.Journal of clinical medicine · 2022Article
- Geriatric emergency department revisits after discharge with Potentially Inappropriate Medications: A retrospective cohort study.The American journal of emergency medicine · 2021Article
- Adverse drug reactions in older adults: a retrospective comparative analysis of spontaneous reports to the German Federal Institute for Drugs and Medical Devices.BMC pharmacology & toxicology · 2020Article
- American Geriatrics Society-Beers Criteria and adverse drug reactions: a comparative cross-sectional study of Nigerian and South African older inpatients.Clinical interventions in aging · 2018Article
- Health Service Use, Costs, and Adverse Events Associated with Potentially Inappropriate Medication in Old Age in Germany: Retrospective Matched Cohort Study.Drugs & aging · 2017Article
- Article
- Liver injury with novel oral anticoagulants: assessing post-marketing reports in the US Food and Drug Administration adverse event reporting system.British journal of clinical pharmacology · 2015Article
- Potentially inappropriate prescribing andthe risk of adverse drug reactions in critically ill older adults.Pharmacy practiceArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLists of potentially inappropriate medications (PIM) in the elderly were developed in order to identify patients and/or drugs at risk of adverse drug reactions (ADRs) or inefficacy. However, the relationship between PIMs and ADRs remains discussed. We hypothesized that PIM use is associated with more ADRs than other prescriptions.
methodsAll ADRs registered by the Midi-Pyrénées PharmacoVigilance Center between the 1st January and the 30th June 2012 in patients ≥75 years were included. Data on patients (age, gender, Charlson comorbidity index), drugs (number, ATC classification, Laroche PIM classification) and ADRs (type, seriousness, mechanisms) were analyzed.
resultsAmong the 923 ADRs recorded, 272 (29.5%) were in patients ≥75 years. Mean age was 83.5 ± 5.5 years. Most of them (59%) were females. Mean Charlson index was 5.6 ± 2.0 by ADR report. These 272 prescriptions involved 1,775 drugs [mean value, 6.5 (±3.4) drugs by ADR report] with 129 (7.3%) PIM. Main PIM classes were nervous (n = 98, 76.0%) and cardiovascular (17.8%) drugs, including 32 atropinics (23.4%). ADR-associated drugs were mainly antithrombotics, antibacterials, and analgesics for non-PIM drugs whereas PIM-associated ADRs were mainly observed with digoxine, psycholeptics, and psychoanaleptics. ADRs were mainly found with non-PIM drugs (89.3%). Associated factors were the number of drugs for PIMs and the number of PIMs for PIM-induced ADRs.
conclusionOut of the ADR reports registered in the Midi-Pyrénées PharmacoVigilance Database for patients ≥75 years, 1 drug out of 12 is potentially inappropriate (mainly benzodiazepines, imipraminic antidepressants, and atropinic drugs). PIM use is not associated with more ADRs' reports than other prescriptions.
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