Trial reportLasers in medical science2014
Acute effects of low-level laser therapy on physiologic and electromyographic responses to the cardiopulmonary exercise testing in healthy untrained adults.
Trial report in Lasers in medical science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 4 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Deconstructing the Ergogenic Effects of Photobiomodulation: A Systematic Review and Meta-analysis of its Efficacy in Improving Mode-Specific Exercise Performance in Humans.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- Pooled it
- Photobiomodulation therapy for the improvement of muscular performance and reduction of muscular fatigue associated with exercise in healthy people: a systematic review and meta-analysis.Lasers in medical science · 2018Pooled it
- Low-level phototherapy to improve exercise capacity and muscle performance: a systematic review and meta-analysis.Lasers in medical science · 2016Pooled it
- A randomised crossover trial comparing photobiomodulation therapy with other recovery strategies in CrossFit athletes.PloS one · 2026Trial
- Influence of photobiomodulation on energy contribution in normoxia and hypoxia conditions in amateur runners: a single-blinded and randomized crossover pilot study.Lasers in medical science · 2024Trial
- Whole-body photobiomodulation improves post-exercise recovery but does not affect performance or physiological response during maximal anaerobic cycling.Lasers in medical science · 2023Trial
- Trial
- LED session prior incremental step test enhance VOLasers in medical science · 2018Trial
- Light-emitting diode therapy (photobiomodulation) effects on oxygen uptake and cardiac output dynamics during moderate exercise transitions: a randomized, crossover, double-blind, and placebo-controlled study.Lasers in medical science · 2018Trial
- When is the best moment to apply photobiomodulation therapy (PBMT) when associated to a treadmill endurance-training program? A randomized, triple-blinded, placebo-controlled clinical trial.Lasers in medical science · 2018Trial
- Low-level laser therapy improves the VOLasers in medical science · 2018Trial
- Dose-response effect of photobiomodulation therapy on neuromuscular economy during submaximal running.Lasers in medical science · 2018Trial
- Muscular pre-conditioning using light-emitting diode therapy (LEDT) for high-intensity exercise: a randomized double-blind placebo-controlled trial with a single elite runner.Physiotherapy theory and practice · 2015Trial
- Photobiomodulation Combined with Moderate or High-Intensity Interval Training on Oxygen Consumption and Exercise Tolerance in Patients with Heart Failure.Arquivos brasileiros de cardiologia · 2025Article
- Photobiomodulation as Medicine: Low-Level Laser Therapy (LLLT) for Acute Tissue Injury or Sport Performance Recovery.Journal of functional morphology and kinesiology · 2024Review
- Effects of Photobiomodulation Therapy on Performance in Successive Time-to-Exhaustion Cycling Tests: A Randomized Double-Blinded Placebo-Controlled Trial.Journal of functional morphology and kinesiology · 2023Article
- Article
- The Influence of Phototherapy on Recovery From Exercise-Induced Muscle Damage.International journal of sports physical therapy · 2022Article
- Does Photobiomodulation Therapy Enhance Maximal Muscle Strength and Muscle Recovery?Journal of human kinetics · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the positive effects of low-level laser therapy (LLLT) on muscle fatigue before exercises using a single muscle group, the acute effects of LLLT on performance in cardiopulmonary exercise testing (CPET) are poorly understood. We aimed to assess the acute effects of LLLT on physiologic and electromyographic responses to the CPET in healthy adults. A randomized, double-blind, placebo-controlled crossover trial was performed with 18 untrained participants (nine males, 22 ± 2 years). We applied LLLT or placebo on quadriceps and gastrocnemius 10 min before two rapidly incremental CPETs randomly performed in alternate days on a cycle ergometer. Participants received LLLT using a multidiode cluster, 20 s/site (850 nm, 100 mW/diode, 14 J/site). Physiological responses to the CPET were continuously monitored using a gas analyzer. The electromyographic fatigue threshold (EMGth) was assessed through surface electrodes on vastus lateralis. The root mean square (RMS) was plotted every 5 s against the exercise intensity, and its breakpoint values throughout the CPET was identified as EMGth. Compared to placebo, the LLLT significantly increased peak O2 uptake (V'O2 33 ± 10 vs. 31 ± 9 mL/min/kg). We observed a shallower slope of the Δheart rate/ΔV'O2 during the CPET after LLLT compared to placebo, i.e., increased cardiovascular efficiency (56 ± 24 vs. 66 ± 30 bpm/L/min). There were no LLLT-related changes in EMGth. The LLLT acutely increases exercise performance in healthy untrained adults probably due to increased O2 extraction by peripheral muscles without causing a significant impact on muscle fatigue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.