Evidence map›Paper›PMID 24925054›Full record

ArticleModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc2015

Primary sources of pelvic serous cancer in patients with endometrial intraepithelial carcinoma.

Lin Jia, Zeng Yuan, Yiying Wang, Janiel M Cragun, Beihua Kong, Wenxin Zheng

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In one paragraph

Article in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. A Comprehensive Review of Ovarian Serous Carcinoma.Advances in anatomic pathology · 2019
    Review
  8. Review
  9. Article
  10. Article
  11. Prior Tubal Ligation Might Influence Metastatic Spread of Nonendometrioid Endometrial Carcinoma.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2016
    Article
  12. Review
  13. Practical issues related to uterine pathology: staging, frozen section, artifacts, and Lynch syndrome.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2016
    Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Lin Jia1] Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Shandong, China [2] Department of Pathology, University of Arizona College of Medicine, Tucson, AZ, USA.
Zeng Yuan1] Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Shandong, China [2] Department of Pathology, University of Arizona College of Medicine, Tucson, AZ, USA.
Yiying Wang1] Department of Pathology, University of Arizona College of Medicine, Tucson, AZ, USA [2] Department of Obstetrics and Gynecology, Henan Provincial People's Hospital, Henan, China.
Janiel M CragunDepartment of Obstetrics and Gynecology, University of Arizona, Tucson, AZ, USA.
Beihua KongDepartment of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Shandong, China.
Wenxin Zheng1] Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Shandong, China [2] Department of Pathology, University of Arizona College of Medicine, Tucson, AZ, USA [3] Department of Obstetrics and Gynecology, University of Arizona, Tucson, AZ, USA [4] Arizona Cancer Center, University of Arizona, Tucson, AZ, USA.
University of Arizona · USQilu Hospital of Shandong University · CN

Funding

VITAMIN AP30CA023074 · NCI · UNIVERSITY OF ARIZONA · PI Dan Theodorescu · 1985 to 2026
$110.2M
NCI NIH HHS P30 CA23074
6 · The paper itself

Abstract

Serous endometrial intraepithelial carcinoma is often associated with extrauterine disease. It is currently unclear where does the extrauterine disease come from. This study addressed this issue. A total of 135 samples from 21 serous endometrial intraepithelial carcinoma patients were studied. Cellular lineage relationships between intrauterine and extrauterine serous carcinomas were determined by TP53-mutation analysis and correlated to the clinicopathologic features. There were three conditions contributing the extrauterine disease: metastasis from serous endometrial intraepithelial carcinoma (n=10) showed identical TP53 mutation between intrauterine lesions and extrauterine disease, cases of adnexal origin (n=5) had discordant TP53 mutations, and the mixed cellular origin cases (n=6) with both identical and discordant mutation status. Patients with extrauterine disease from serous endometrial intraepithelial carcinoma metastasis typically had small tumor masses (<2 cm) in extrauterine sites and without finding of serous tubal intraepithelial carcinoma, while extrauterine disease with adnexal or tubal origin commonly had larger tumor masses in extrauterine sites including ovary and omentum and serous tubal intraepithelial carcinoma. The majority of extrauterine diseases associated with serous endometrial intraepithelial carcinoma are metastasized from the endometrium. Serous endometrial intraepithelial carcinoma is frequently associated with serous cancers of adnexal or tubal origin, indicating that endometrial and adnexal or tubal serous cancers may share similar etiologies. TP53-mutation analysis provides a strong linkage for cellular lineage analysis. Tumor size in extrauterine disease and presence of serous tubal intraepithelial carcinoma or not are useful clinicopathologic features to determine primary cancer site, which helps in clinical management.

Indexed as

AgedAged, 80 and overCarcinoma in SituCystadenocarcinoma, SerousDNA Mutational AnalysisEndometrial NeoplasmsFallopian Tube NeoplasmsFemaleHumansImmunohistochemistryLaser Capture MicrodissectionMiddle AgedPelvic NeoplasmsPolymerase Chain ReactionTumor Suppressor Protein p53Tumor Suppressor Protein p53

Identifiers

PMID24925054
OpenAlexW2035833438

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.