ArticlePloS one2014
Milk oligosaccharides over time of lactation from different dog breeds.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Effect of Bovine Colostrum on Canine Immune Health.Animals : an open access journal from MDPI · 2025Review
- MilkOligoCorpus: A semantically annotated resource for knowledge extraction on mammalian milk oligosaccharides.PloS one · 2025Article
- Comparison of canine colostrum and milk using a multi-omics approach.Animal microbiome · 2024Article
- Comparative analysis of oligosaccharides in the milk of human and animals by using LC-QE-HF-MS.Food chemistry: X · 2023Article
- Creation of a milk oligosaccharide database, MilkOligoDB, reveals common structural motifs and extensive diversity across mammals.Scientific reports · 2023Article
- Lactation in domestic carnivores.Animal frontiers : the review magazine of animal agriculture · 2023Article
- Effects of a milk oligosaccharide biosimilar on fecal characteristics, microbiota, and bile acid, calprotectin, and immunoglobulin concentrations of healthy adult dogs treated with metronidazole.Journal of animal science · 2023Article
- Analysis and Comparison of Nutrition Profiles of Canine Milk with Bovine and Caprine Milk.Foods (Basel, Switzerland) · 2022Article
- Effect of a novel animal milk oligosaccharide biosimilar on macronutrient digestibility and gastrointestinal tolerance, fecal metabolites, and fecal microbiota of healthy adult cats.Journal of animal science · 2021Article
- Effect of a novel animal milk oligosaccharide biosimilar on the gut microbial communities and metabolites of in vitro incubations using feline and canine fecal inocula.Journal of animal science · 2020Article
- Chemical structures of oligosaccharides in milks of the American black bear (Ursus americanus americanus) and cheetah (Acinonyx jubatus).Glycoconjugate journal · 2020Article
- High-throughput glycomic analyses reveal unique oligosaccharide profiles of canine and feline milk samples.PloS one · 2020Article
- Chemical structures of oligosaccharides in milk of the raccoon (Procyon lotor).Glycoconjugate journal · 2018Article
- Sialic acids as link to Japanese scientists.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2016Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The partnership of humans and dogs goes back to over 10'000 years, yet relatively little is known about a dog's first extra-uterine nutrition particularly when it comes to milk oligosaccharides. We set out to identify and quantify milk oligosaccharides over the course of lactation from different dog breeds (Labrador retriever, Schnauzer and 3 Alaskan husky crossbreeds). To this end, 2 different chromatographic methods with fluorescence and mass spectrometry detection were developed and one was validated for quantification. Besides lactose and lactose-sulphate, we identified 2 different trisaccharides composed of 3 hexose units, 3'sialyllactose (3'SL), 6'sialyllactose (6'SL), 2'fucosyllactose (2'FL), and a tetrasaccharide composed of 2 hexoses, an N-acetylhexosamine and a deoxyhexose. 3'SL was present at the highest levels in milk of all dog breeds starting at around 7.5 g/L and dropping to about 1.5 g/L in the first 10 days of lactation. 6'SL was about 10 times less abundant and 2'FL and the tetrasaccharide had rather varying levels in the milk of the different breeds with the tetrasaccharide only detectable in the Alaskan husky crossbreeds. The longitudinal and quantitative data of milk oligosaccharides from different dog breeds are an important basis to further our understanding on their specific biological roles and also on the specific nutritional requirements of lactating puppies.
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