Trial reportThe British journal of surgery2014
Patient-reported genitourinary dysfunction after laparoscopic and open rectal cancer surgery in a randomized trial (COLOR II).
Trial report in The British journal of surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT00297791 (A Randomized Clinical Trial Comparing Laparoscopic and Open Surgery for Rectal Cancer.), which is not on this map. Cited by 50 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Clinical Trial Comparing Laparoscopic and Open Surgery for Rectal Cancer.
Who cites it
50 citing papers in PubMed, 9 syntheses or guidelines pooled it, 129 citations in OpenAlex.
- Systematic review of the feasibility of sparing the rectoprostatic fascia in male patients undergoing total mesorectal excision for rectal cancer.Techniques in coloproctology · 2024Pooled it
- Endoscopic and trans-anal local excision vs. radical resection in the treatment of early rectal cancer: A systematic review and network meta-analysis.International journal of colorectal disease · 2023Pooled it
- Comparing functional outcomes between transanal total mesorectal excision (TaTME) and laparoscopic total mesorectal excision (LaTME) for rectal cancer: a systematic review and meta-analysis.International journal of colorectal disease · 2021Pooled it
- Functional complaints and quality of life after transanal total mesorectal excision: a meta-analysis.The British journal of surgery · 2020Pooled it
- Pooled it
- Quality of life in patients treated for anal carcinoma-a systematic literature review.International journal of colorectal disease · 2019Pooled it
- Induced Bias Due to Crossover Within Randomized Controlled Trials in Surgical Oncology: A Meta-regression Analysis of Minimally Invasive versus Open Surgery for the Treatment of Gastrointestinal Cancer.Annals of surgical oncology · 2018Pooled it
- Laparoscopic Versus Open Surgery for Mid-Low Rectal Cancer: a Systematic Review and Meta-Analysis on Short- and Long-Term Outcomes.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2015Pooled it
- PDE-5i Management of Erectile Dysfunction After Rectal Surgery: A Systematic Review Focusing on Treatment Efficacy.American journal of men's healthPooled it
- Developing a multivariable prediction model of global health-related quality of life in patients treated for rectal cancer: a prospective study in five countries.International journal of colorectal disease · 2024Trial
- Study protocol for a multicenter prospective controlled and randomized trial of transanal total mesorectal excision versus laparoscopic low anterior resection in rectal cancer.International journal of colorectal disease · 2018Trial
- Trial
- Evaluation of analytical models to estimate depth of fluorescence objects in biological media.Journal of biomedical optics · 2026Article
- Sexual dysfunction after colorectal and anal cancer-treatment in nurse-led sexological clinics.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2025Article
- Advantages of robotic surgery for rectal cancer compared to laparoscopic surgery: pelvic anatomy and its impact on urinary dysfunction.Journal of robotic surgery · 2024Article
- The erectile and ejaculatory implications of the surgical management of rectal cancer.International journal of urology : official journal of the Japanese Urological Association · 2023Review
- Possible Advantages of Minimal-Invasive Approaches in Rectal Cancer Surgery: A Nationwide Analysis.Journal of clinical medicine · 2023Article
- Local versus radical surgery for early rectal cancer with or without neoadjuvant or adjuvant therapy.The Cochrane database of systematic reviews · 2023Review
- Outcomes of open vs laparoscopic vs robotic vs transanal total mesorectal excision (TME) for rectal cancer: a network meta-analysis.Techniques in coloproctology · 2023Review
- The Quality of Life of Patients with Surgically Treated Colorectal Cancer: A Narrative Review.Journal of clinical medicine · 2022Review
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis article reports on patient-reported sexual dysfunction and micturition symptoms following a randomized trial of laparoscopic and open surgery for rectal cancer.
methodsPatients in the COLOR II randomized trial, comparing laparoscopic and open surgery for rectal cancer, completed the European Organization for Research and Treatment of Cancer (EORTC) QLQ-CR38 questionnaire before surgery, and after 4 weeks, 6, 12 and 24 months. Adjusted mean differences on a 100-point scale were calculated using changes from baseline value at the various time points in the domains of sexual functioning, sexual enjoyment, male and female sexual problems, and micturition symptoms.
resultsOf 617 randomized patients, 385 completed this phase of the trial. Their mean age was 67·1 years. Surgery caused an anticipated reduction in genitourinary function after 4 weeks, with no significant differences between laparoscopic and open approaches. An improvement in sexual dysfunction was seen in the first year, but some male sexual problems persisted. Before operation 64·5 per cent of men in the laparoscopic group and 55·6 per cent in the open group reported some degree of erectile dysfunction. This increased to 81·1 and 80·5 per cent respectively 4 weeks after surgery, and 76·3 versus 75·5 per cent at 12 months, with no significant differences between groups. Micturition symptoms were less affected than sexual function and gradually improved to preoperative levels by 6 months. Adjusting for confounders, including radiotherapy, did not change these results.
conclusionSexual dysfunction is common in patients with rectal cancer, and treatment (including surgery) increases the proportion of patients affected. A laparoscopic approach does not change this. REGISTRATION NUMBER: NCT00297791 (http://www.clinicaltrials.gov).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.