Evidence map›Paper›PMID 24924619›Full record

ArticleHeart (British Cardiac Society)2014

Circulating levels of liver enzymes and incidence of atrial fibrillation: the Atherosclerosis Risk in Communities cohort.

Alvaro Alonso, Jeffrey R Misialek, Mohamed A Amiin, Ron C Hoogeveen, Lin Y Chen, Sunil K Agarwal, Laura R Loehr, Elsayed Z Soliman, Elizabeth Selvin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heart (British Cardiac Society), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 94 citations in OpenAlex.

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  10. Non-vitamin K antagonist oral anticoagulants in atrial fibrillation patients with advanced chronic kidney and liver diseases.European heart journal supplements : journal of the European Society of Cardiology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Alvaro AlonsoDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minneapolis, USA.
Jeffrey R MisialekDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minneapolis, USA.
Mohamed A AmiinDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minneapolis, USA.
Ron C HoogeveenDepartment of Medicine, Baylor College of Medicine and Methodist DeBakey Heart & Vascular Center, Houston, Texas, USA.
Lin Y ChenDivision of Cardiology, University of Minnesota Medical School, Minneapolis, Minneapolis, USA.
Sunil K AgarwalDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Laura R LoehrDepartment of Epidemiology, Gillings School of Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.
Elsayed Z SolimanEpidemiological Cardiology Research Center (EPICARE), Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Elizabeth SelvinDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
University of Minnesota · USJohns Hopkins University · USBaylor College of Medicine · USUniversity of Minnesota Medical Center · USUniversity of North Carolina at Chapel Hill · USWake Forest University · US

Funding

Epidemiologic Study of Risk Factors and Biomarkers of Atrial FibrillationRC1HL099452 · NHLBI · UNIVERSITY OF MINNESOTA · PI ALONSO, ALVARO · 2009 to 2010
$897k
NHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS RC1 HL099452
6 · The paper itself

Abstract

backgroundElevated levels of circulating liver enzymes have been associated with increased risk of cardiovascular disease. Their possible association with atrial fibrillation (AF) has received little attention.

methodsWe studied 9333 men and women, aged 53-75 years, free of AF, participating in the Atherosclerosis Risk in Communities Study followed-up from 1996 to 2010. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), and γ glutamyl transpeptidase (GGT) were measured in stored plasma samples. Incident AF was ascertained from hospitalisations and death certificates. Associations between liver enzymes and AF incidence were assessed using multivariable Cox proportional hazards models.

resultsDuring a mean follow-up of 12 years, 1021 incident AF events were identified. Levels of AST, and to a lesser extent ALT, showed a U-shaped association with AF risk, with higher AF risk among individuals in the two extremes of the distribution in minimally adjusted models. The associations were weakened after adjustment for potential confounders. By contrast, GGT, modelled as log base 2, was linearly associated with AF risk after multivariable adjustment: a doubling of GGT levels was associated with a 20% increased risk of AF (95% CI 10% to 30%). Additional adjustment for inflammatory markers did not appreciably affect the results. Associations were not different in men and women, in whites and blacks, among never drinkers of alcohol, and among those without prevalent heart failure.

conclusionsIn this community-based prospective study, higher levels of liver enzymes, mainly GGT, were associated with an increased risk of AF. The mechanisms underlying this association deserve further scrutiny.

Indexed as

Alcohol DrinkingAtrial FibrillationAgedAlanine TransaminaseAspartate AminotransferasesBiomarkersEthnicityFemaleFollow-Up Studiesgamma-GlutamyltransferaseHospitalizationHumansMaleProportional Hazards ModelsProspective StudiesRisk AssessmentAlanine TransaminaseAspartate AminotransferasesBiomarkersgamma-Glutamyltransferase

Identifiers

PMID24924619
PMCPMC4225783
OpenAlexW2123326326

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.