ArticlePsycho-oncology2015
Depressive symptomatology in men receiving androgen deprivation therapy for prostate cancer: a controlled comparison.
Article in Psycho-oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- A systematic review of risk factors associated with depression and anxiety in cancer patients.PloS one · 2024Pooled it
- Incidence of the adverse effects of androgen deprivation therapy for prostate cancer: a systematic literature review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020Pooled it
- Effects of web-based cognitive behavioral stress management and health promotion interventions on neuroendocrine and inflammatory markers in men with advanced prostate cancer: A randomized controlled trial.Brain, behavior, and immunity · 2021Trial
- Trial
- Dihydrotestosterone regulation of stress-related behaviors in mice exposed to subchronic variable stress.Psychoneuroendocrinology · 2025Article
- Study on the Impact of Hormone Therapy for Prostate Cancer on the Quality of Life and the Psycho-Relational Sphere of Patients: ProQoL.Oncology and therapy · 2025Article
- Maternal steroids during pregnancy and their associations with exposure to lifetime stressful life events, prenatal stress appraisal and psychological functioning.Psychoneuroendocrinology · 2023Article
- Analysis of Frailty Syndrome in Men with Metastatic Prostate Cancer: A Scoping Review.Journal of personalized medicine · 2023Article
- The role of testosterone, the androgen receptor, and hypothalamic-pituitary-gonadal axis in depression in ageing Men.Reviews in endocrine & metabolic disorders · 2022Review
- Antidepressant medication use and prostate cancer recurrence in men with depressive disorders.Cancer causes & control : CCC · 2022Article
- Androgen Regulation of Corticotropin Releasing Factor Receptor 1 in the Mouse Brain.Neuroscience · 2022Article
- Article
- Association of Second-generation Antiandrogens With Depression Among Patients With Prostate Cancer.JAMA network open · 2021Article
- Article
- Analysis of Brain Functions in Men with Prostate Cancer under Androgen Deprivation Therapy: A One-Year Longitudinal Study.Life (Basel, Switzerland) · 2021Article
- Evaluating a web- and telephone-based personalised exercise intervention for individuals living with metastatic prostate cancer (ExerciseGuide): protocol for a pilot randomised controlled trial.Pilot and feasibility studies · 2021Article
- Androgens and Their Role in Regulating Sex Differences in the Hypothalamic/Pituitary/Adrenal Axis Stress Response and Stress-Related Behaviors.Androgens: clinical research and therapeutics · 2021Review
- Roles for androgens in mediating the sex differences of neuroendocrine and behavioral stress responses.Biology of sex differences · 2020Review
- Androgen Deprivation Therapy and Cognitive Function in Prostate Cancer.Current oncology reports · 2020Review
- Changes in Beck Depression Inventory scores in prostate cancer patients undergoing androgen deprivation therapy or prostatectomy.PloS one · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveProstate cancer patients who receive androgen deprivation therapy (ADT) often experience many physical and psychological side effects. ADT may be associated with increased risk for depression, but the relationship between ADT and depression is not fully understood. This study used a longitudinal design to assess depressive symptomatology in patients receiving ADT compared with two groups of matched controls.
methodsParticipants were men initiating ADT treatment (ADT+ group; n = 61) and their matched controls: prostate cancer patients treated with radical prostatectomy (ADT- group; n = 61), and no-cancer controls (CA- group; n = 61). Depressive symptomatology was assessed using the Center for Epidemiological Studies Depression Scale at ADT initiation and again 6 months later. Differences in depressive symptomatology and rates of clinically significant depressive symptomatology were analyzed between groups at each time point and within groups over time.
resultsBetween baseline and follow-up, ADT+ participants demonstrated increased depressive symptomatology and increased rates of clinically significant depressive symptomatology (ps < 0.05). ADT+ participants also reported greater depressive symptomatology than both control groups at follow-up (ps < 0.001). Rates of clinically significant depressive symptomatology were higher in the ADT+ group than the ADT- and CA- groups at both time points (baseline: 28%, 5%, 12%; follow-up: 39%, 9%, 11%).
conclusionsFindings support the hypothesis that ADT administration yields increases in depression and suggest that the mechanism behind ADT's association with depression should be explored and that prostate cancer patients treated with ADT should receive particular focus in depression screening and intervention.
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