ArticleJournal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus2014
Retinopathy of prematurity and brain damage in the very preterm newborn.
Article in Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Pooled it
- Retinopathy of Prematurity and Neurodevelopmental and Quality-of-Life Outcomes at 10 Years of Age.American journal of perinatology · 2026Article
- Prevalence of strabismus, nystagmus and risk factors in children and adolescents born preterm with and without retinopathy of prematurity: results from the Gutenberg Prematurity Study Young.The British journal of ophthalmology · 2026Article
- Visual acuity outcomes up to 12 years and risk factors for visual impairment in a national cohort of extremely preterm born children - The Extremely Preterm Infants in Sweden Study (EXPRESS).Acta ophthalmologica · 2026Article
- Long-term visual function and refractive changes after vitrectomy for stage 4 retinopathy of prematurity.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Retinopathy of prematurity and neurodevelopmental outcome and quality of life at 10 years of age.Research square · 2024Article
- Relationships between retinopathy of prematurity without ophthalmologic intervention and neurodevelopment and vision at 2 years.Pediatric research · 2023Article
- Retinopathy of prematurity and neurodevelopmental outcomes in preterm infants: A systematic review and meta-analysis.Frontiers in pediatrics · 2023Review
- Association of sedation and anesthesia on cognitive outcomes in very premature infants: a retrospective observational study.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2023Observational
- Article
- Neurosensory Alterations in Retinopathy of Prematurity: A Window to Neurological Impairments Associated to Preterm Birth.Biomedicines · 2022Review
- Severe Retinopathy of Prematurity Associated With Neurodevelopmental Disorder in Children.Frontiers in pediatrics · 2022Article
- Analysis of Brain Injury Biomarker Neurofilament Light and Neurodevelopmental Outcomes and Retinopathy of Prematurity Among Preterm Infants.JAMA network open · 2021Article
- Severe Retinopathy of Prematurity Is Not Independently Associated With Worse Neurodevelopmental Outcomes in Preterm Neonates.Frontiers in pediatrics · 2021Article
- Serious neonatal morbidities are associated with differences in DNA methylation among very preterm infants.Clinical epigenetics · 2020Article
- The fetal inflammatory response syndrome: the origins of a concept, pathophysiology, diagnosis, and obstetrical implications.Seminars in fetal & neonatal medicine · 2020Article
- The association between high levels of luteinizing hormone and proliferative retinopathy of prematurity in female preterm infants.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2020Article
- Antecedents of Objectively Diagnosed Diffuse White Matter Abnormality in Very Preterm Infants.Pediatric neurology · 2020Article
- Relation of Retinopathy of Prematurity to Brain Volumes at Term Equivalent Age and Developmental Outcome at 2 Years of Corrected Age in Very Preterm Infants.Neonatology · 2018Article
- Systemic Inflammation-Associated Proteins and Retinopathy of Prematurity in Infants Born Before the 28th Week of Gestation.Investigative ophthalmology & visual science · 2017Observational
Corrections and comments
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Authors and funding
17 authors at 10 institutions in 2 countries.
Funding
Abstract
purposeTo explain why very preterm newborns who develop retinopathy of prematurity (ROP) appear to be at increased risk of abnormalities of both brain structure and function.
methodsA total of 1,085 children born at <28 weeks' gestation had clinically indicated retinal examinations and had a developmental assessment at 2 years corrected age. Relationships between ROP categories and brain abnormalities were explored using logistic regression models with adjustment for potential confounders.
resultsThe 173 children who had severe ROP, defined as prethreshold ROP (n = 146) or worse (n = 27) were somewhat more likely than their peers without ROP to have brain ultrasound lesions or cerebral palsy. They were approximately twice as likely to have very low Bayley Scales scores. After adjusting for risk factors common to both ROP and brain disorders, infants who developed severe ROP were at increased risk of low Bayley Scales only. Among children with prethreshold ROP, exposure to anesthesia was not associated with low Bayley Scales.
conclusionsSome but not all of the association of ROP with brain disorders can be explained by common risk factors. Most of the increased risks of very low Bayley Scales associated with ROP are probably not a consequence of exposure to anesthetic agents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.