ArticleDevelopment (Cambridge, England)2014
The dynamic DNA methylation cycle from egg to sperm in the honey bee Apis mellifera.
Article in Development (Cambridge, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 67 citations in OpenAlex.
- Sex-biased DNA methylation in small hive beetles (Aethina tumida).Insect molecular biology · 2026Article
- Unraveling the Roles of Epigenetic Regulators During the Embryonic Development ofInternational journal of molecular sciences · 2025Article
- Epigenetic Mechanisms inCurrent issues in molecular biology · 2025Review
- The functions of DNA methyltransferases during the feeding and development of Haemaphysalis longicornis are potentially associated with lysosome pathways.BMC genomics · 2024Article
- A postmeiotically bifurcated roadmap of honeybee spermatogenesis marked by phylogenetically restricted genes.PLoS genetics · 2023Article
- Genome-wide DNA methylation patterns in bumble bee (Bombus vosnesenskii) populations from spatial-environmental range extremes.Scientific reports · 2023Article
- TheNAR genomics and bioinformatics · 2023Article
- Epigenetic regulations as drivers of insecticide resistance and resilience to climate change in arthropod pests.Frontiers in genetics · 2022Review
- Intergenerational transfer of DNA methylation marks in the honey bee.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Epigenetic Molecular Mechanisms in Insects.Neotropical entomology · 2020Review
- Lineage and Parent-of-Origin Effects in DNA Methylation of Honey Bees (Apis mellifera) Revealed by Reciprocal Crosses and Whole-Genome Bisulfite Sequencing.Genome biology and evolution · 2020Article
- DNA methylation is maintained with high fidelity in the honey bee germline and exhibits global non-functional fluctuations during somatic development.Epigenetics & chromatin · 2019Article
- Evolutionary transition between invertebrates and vertebrates via methylation reprogramming in embryogenesis.National science review · 2019Article
- Unique DNA Methylation Profiles Are Associated with cis-Variation in Honey Bees.Genome biology and evolution · 2019Article
- Identification and sequencing of the gene encoding DNA methyltransferase 3 (DNMT3) from sea cucumber, Apostichopus japonicus.Molecular biology reports · 2019Article
- DNA demethylation by ROS1a in rice vegetative cells promotes methylation in sperm.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Social context influences the expression of DNA methyltransferase genes in the honeybee.Scientific reports · 2018Article
- Notos - a galaxy tool to analyze CpN observed expected ratios for inferring DNA methylation types.BMC bioinformatics · 2018Article
- DNA methylation is not involved in dietary restriction induced lifespan extension in adult Drosophila.Genetics research · 2018Article
- Do social insects support Haig's kin theory for the evolution of genomic imprinting?Epigenetics · 2017Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
In honey bees (Apis mellifera), the epigenetic mark of DNA methylation is central to the developmental regulation of caste differentiation, but may also be involved in additional biological functions. In this study, we examine the whole genome methylation profiles of three stages of the haploid honey bee genome: unfertilised eggs, the adult drones that develop from these eggs and the sperm produced by these drones. These methylomes reveal distinct patterns of methylation. Eggs and sperm show 381 genes with significantly different CpG methylation patterns, with the vast majority being more methylated in eggs. Adult drones show greatly reduced levels of methylation across the genome when compared with both gamete samples. This suggests a dynamic cycle of methylation loss and gain through the development of the drone and during spermatogenesis. Although fluxes in methylation during embryogenesis may account for some of the differentially methylated sites, the distinct methylation patterns at some genes suggest parent-specific epigenetic marking in the gametes. Extensive germ line methylation of some genes possibly explains the lower-than-expected frequency of CpG sites in these genes. We discuss the potential developmental and evolutionary implications of methylation in eggs and sperm in this eusocial insect species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.