Evidence map›Paper›PMID 24923985›Full record

ArticlePsychopharmacology2015

Accounting for sex-related differences in the estimation of breath alcohol concentrations using transdermal alcohol monitoring.

Nathalie Hill-Kapturczak, John D Roache, Yuanyuan Liang, Tara E Karns, Sharon E Cates, Donald M Dougherty

Registry-linked trialAbstract read
In one paragraph

Article in Psychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05692830 (Towards a Wearable Alcohol Biosensor), which is not on this map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05692830 recruitingnot on this mapstarted 2022, after this paper: background citation

Towards a Wearable Alcohol Biosensor: Examining the Accuracy of BAC Estimates From New-Generation Transdermal Technology Using Large-Scale Human Testing and Machine Learning Algorithms

TypeobservationalSponsorUniversity of Illinois at Urbana-ChampaignRan2022 to 2027Enrolled240ConditionsAlcohol Drinking, Alcohol IntoxicationArmsAlcohol
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Using Transdermal Alcohol Monitoring to Detect Low-Level Drinking.Alcoholism, clinical and experimental research · 2015
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nathalie Hill-KapturczakDepartment of Psychiatry, The University of Texas Health Science Center at San Antonio, NRLC MC 7793, 7703 Floyd Curl Drive, San Antonio, TX, 78229-3900, USA.
John D Roache
Yuanyuan Liang
Tara E Karns
Sharon E Cates
Donald M Dougherty

Funding

Leveraging Transdermal Alcohol Monitoring to Reduce Drinking among DWI DefendantsR01AA014988 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DOUGHERTY, DONALD M, HILL-KAPTURCZAK, NATHALIE · 2005 to 2021
$8.6M
Training in Drug Abuse Research: Behavior and NeurobiologyT32DA031115 · NIDA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CHARLES P FRANCE · 2011 to 2026
$5.2M
NIAAA NIH HHS R01 AA014988NIAAA NIH HHS R01AA14988NIDA NIH HHS T32 DA031115NIDA NIH HHS T32DA031115
6 · The paper itself

Abstract

rationalePreviously, we reported methods to estimate peak breath alcohol concentrations (BrAC) from transdermal alcohol concentrations (TAC) under conditions where alcohol consumption was controlled to produce similar BrAC levels in both sexes.

objectiveThis study characterized differences in the relationship between BrAC and TAC as a function of sex and developed a model to predict peak BrAC that accounts for known sex differences in peak BrAC.

methodsTAC and BrAC were monitored during the consumption of a varying number of beers on different days. Both men (n=11) and women (n=10) consumed one, two, three, four, and five beers at the same rate in a 2-h period. Sex and sex-related variables were considered for inclusion in a multilevel model to develop an equation to estimate peak BrAC levels from TAC.

resultsWhile peak BrAC levels were significantly higher in women than men, sex differences were not significant in observed TAC levels. This lack of correspondence was evidenced by significant sex differences in the relationship between peak TAC and peak BrAC. The best model to estimate peak BrAC accounted for sex-related differences by including peak TAC, time-to-peak TAC, and sex. This model was further validated using previously collected data.

conclusionsThe relationship between peak TAC and actual peak BrAC differs between men and women, and these differences can be accounted for in a statistical model to better estimate peak BrAC. Further studies are required to extend these estimates of peak BrAC to the outpatient environment where naturalistic drinking occurs.

Indexed as

BeerSex CharacteristicsAdultAlcohol DrinkingAlcoholic IntoxicationBreath TestsEthanolFemaleHumansMaleMiddle AgedSkin AbsorptionSubstance Abuse DetectionYoung AdultEthanol

Identifiers

PMID24923985
PMCPMC4265311

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.