ArticleNeuro-oncology2014
Navigated transcranial magnetic stimulation improves the treatment outcome in patients with brain tumors in motor eloquent locations.
Article in Neuro-oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 5 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
66 citing papers in PubMed, 5 syntheses or guidelines pooled it, 166 citations in OpenAlex.
- Preoperative assessment of eloquence in neurosurgery: a systematic review.Journal of neuro-oncology · 2023Pooled it
- Comparison of direct cortical stimulation and transcranial magnetic stimulation in brain tumor surgery: systematic review and meta analyses.Journal of neuro-oncology · 2023Pooled it
- Surgical management of Glioma Grade 4: technical update from the neuro-oncology section of the Italian Society of Neurosurgery (SINch®): a systematic review.Journal of neuro-oncology · 2023Pooled it
- Pooled it
- Navigated Transcranial Magnetic Stimulation Motor Mapping Usefulness in the Surgical Management of Patients Affected by Brain Tumors in Eloquent Areas: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2021Pooled it
- From Functional Mapping to Functional Recovery: The Emerging Role of Neuronavigated rTMS in Neurorehabilitation.Brain sciences · 2026Review
- Neuromodulation in Neuro-Oncology: A Scoping Review.Journal of personalized medicine · 2026Review
- Navigated Transcranial Magnetic Stimulation (nTMS): From Functional Brain Mapping to Clinical Applications in Neurosurgery and Neurology.Biomedicines · 2026Review
- Electric field spread contributes to stimulation intensity-dependent expansion of navigated transcranial magnetic stimulation motor map.Clinical neurophysiology practice · 2026Article
- Effect of navigated transcranial magnetic stimulation for glioma surgery outcomes: a systematic review and meta-analysis.Open medicine (Warsaw, Poland) · 2026Article
- The Weight of Eloquence in Motor Area Glioblastoma: Oncologic Outcome After nTMS-Guided Surgical Resection.NeuroSci · 2025Article
- Analysis of Neuronal Excitability Profiles for Motor-Eloquent Brain Tumor Entities Using nTMS in 800 Patients.Cancers · 2025Article
- Real-Time Tractography-Assisted Neuronavigation for Transcranial Magnetic Stimulation.Human brain mapping · 2025Article
- Editorial: Clinical therapy of brain tumors.Frontiers in neurology · 2025Article
- Preoperative nTMS analysis: a sensitive tool to detect imminent motor deficits in brain tumor patients.Acta neurochirurgica · 2024Review
- Article
- NTMS based tractography and segmental diffusion analysis in patients with brainstem gliomas: Risk stratification and clinical potential.Brain & spine · 2024Article
- Preoperative mapping techniques for brain tumor surgery: a systematic review.Frontiers in oncology · 2024Review
- Cortical-Subcortical Functional Preservation and Rehabilitation in Neuro-Oncology:Journal of personalized medicine · 2023Article
- Assessing informative tract segmentation and nTMS for pre-operative planning.Journal of neuroscience methods · 2023Article
6 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeurological and oncological outcomes of motor eloquent brain-tumor patients depend upon the ability to localize functional areas and the respective proposed therapy. We set out to determine whether the use of navigated transcranial magnetic stimulation (nTMS) had an impact on treatment and outcome in patients with brain tumors in motor eloquent locations.
methodsWe enrolled 250 consecutive patients and compared their functional and oncological outcomes to a matched pre-nTMS control group (n = 115).
resultsnTMS mapping results disproved suspected involvement of primary motor cortex in 25.1% of cases, expanded surgical indication in 14.8%, and led to planning of more extensive resection in 35.2% of cases and more restrictive resection in 3.5%. In comparison with the control group, the rate of gross total resections increased significantly from 42% to 59% (P < .05). Progression-free-survival for low grade glioma was significantly better in the nTMS group at 22.4 months than in control group at 15.4 months (P < .05). Integration of nTMS led to a nonsignificant change of postoperative deficits from 8.5% in the control group to 6.1% in the nTMS group.
conclusionsnTMS provides crucial data for preoperative planning and surgical resection of tumors involving essential motor areas. Expanding surgical indications and extent of resection based on nTMS enables more patients to undergo surgery and might lead to better neurological outcomes and higher survival rates in brain tumor patients. The impact of this study should go far beyond the neurosurgical community because it could fundamentally improve treatment and outcome, and its results will likely change clinical practice.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.