ArticlePlanta2014
Characterization of an apple TT2-type R2R3 MYB transcription factor functionally similar to the poplar proanthocyanidin regulator PtMYB134.
Article in Planta, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 77 citations in OpenAlex.
- Gene network analysis predicts the primary regulators of ABA-dependent transcriptional activation and repression in Populus roots.PLoS genetics · 2026Article
- Molecular insights into the regulation of flavonoid biosynthesis in fruits.Horticulture research · 2026Article
- The Mechanism of TT2-TypePlants (Basel, Switzerland) · 2025Article
- StMYB308L and its regulatory role in flavonoid biosynthesis pathways in potato.BMC plant biology · 2025Article
- Article
- Hypermethylation in the promoter regions of flavonoid pathway genes is associated with skin color fading during 'Daihong' apple fruit development.Horticulture research · 2024Article
- Identification and Functional Analysis of the Promoter of a Leucoanthocyanidin Reductase Gene from Gossypium hirsutum.Molecular biotechnology · 2023Article
- Comparative transcriptome analysis identifies candidate genes related to seed coat color in rapeseed.Frontiers in plant science · 2023Article
- Flavonoids - flowers, fruit, forage and the future.Journal of the Royal Society of New Zealand · 2023Review
- Article
- Molecular Mechanisms of Plant Trichome Development.Frontiers in plant science · 2022Review
- The Transcription Factor MdERF78 Is Involved in ALA-Induced Anthocyanin Accumulation in Apples.Frontiers in plant science · 2022Article
- Regulation of Plant Tannin Synthesis in Crop Species.Frontiers in genetics · 2022Review
- Proanthocyanidins and Where to Find Them: A Meta-Analytic Approach to Investigate Their Chemistry, Biosynthesis, Distribution, and Effect on Human Health.Antioxidants (Basel, Switzerland) · 2021Review
- Comparative transcriptome analysis reveals regulatory network and regulators associated with proanthocyanidin accumulation in persimmon.BMC plant biology · 2021Article
- Comparative Metabolite and Gene Expression Analyses in Combination With Gene Characterization Revealed the Patterns of Flavonoid Accumulation DuringFrontiers in plant science · 2021Article
- MrMYB6 From Chinese Bayberry (Frontiers in plant science · 2021Article
- Advances in Biosynthesis and Biological Functions of Proanthocyanidins in Horticultural Plants.Foods (Basel, Switzerland) · 2020Review
- MBW complexes impinge on anthocyanidin reductase gene regulation for proanthocyanidin biosynthesis in persimmon fruit.Scientific reports · 2020Article
- De novo transcriptomic analysis of light-induced flavonoid pathway, transcription factors in the flower buds ofTrees (Berlin, Germany : West) · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MAIN
conclusionThe apple MdMYB9 gene encodes a positive regulator of proanthocyanidin synthesis that activates anthocyanidin reductase promoters from apple and poplar via interaction with basic helix-loop-helix proteins. The regulation of proanthocyanidins (PAs, condensed tannins) is of great importance in food plants due to the many benefits of PAs in the human diet. Two candidate flavonoid MYB regulators, MdMYB9 and MdMYB11, were cloned from apple (Malus × domestica) based on their similarity to known MYB PA regulators. Transcript accumulation of both MdMYB9 and MdMYB11 was induced by high light and wounding, similar to the poplar (Populus spp) PA regulator PtMYB134. In transient activation assays with various basic helix-loop-helix (bHLH) co-regulators, MdMYB9 activated apple and poplar anthocyanidin reductase (ANR) promoters, while MdMYB11 showed no activity. Potential transcription factor binding elements were found within several ANR promoters, and the importance of the bHLH binding site (E-box) on ANR promoter activation was demonstrated via mutational analysis. The ability of MdMYB9 and PtMYB134 to reciprocally activate ANR promoters from both apple and poplar and to partner with heterologous bHLH co-factors from these plants confirms the high degree of conservation of PA regulatory complexes across species. The similarity in apple and poplar PA regulation suggests that regulatory genes from poplar could be effectively employed for metabolic engineering of the PA pathway in apple.
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