Evidence map›Paper›PMID 24923657›Full record

ReviewProgress in neurobiology

Neurobiology of microglial action in CNS injuries: receptor-mediated signaling mechanisms and functional roles.

Xiaoming Hu, Anthony K F Liou, Rehana K Leak, Mingyue Xu, Chengrui An, Jun Suenaga, Yejie Shi, Yanqin Gao, Ping Zheng, Jun Chen

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Progress in neurobiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Microglial activation and RAS signaling: a dual-edged sword in neuroinflammation.American journal of physiology. Regulatory, integrative and comparative physiology · 2026
    Review
  3. Article
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  7. Article
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  16. Microglial phagocytosis and regulatory mechanisms after stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Article
  17. Review
  18. Microglia as Therapeutic Target for Radiation-Induced Brain Injury.International journal of molecular sciences · 2022
    Review
  19. Review
  20. Adhesion Molecules ICAM-1 and PECAM-1 as Potential Biomarkers of Central Nervous System Damage in Women Breast Cancer Survivors.Pathophysiology : the official journal of the International Society for Pathophysiology · 2022
    Article

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiaoming HuCenter of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; State Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, Fudan University, Shanghai, China; Geriatric Research, Educational and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA 15240, USA. Electronic address: hux2@upmc.edu.
Anthony K F LiouCenter of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Rehana K LeakDivision of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, USA.
Mingyue XuState Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, Fudan University, Shanghai, China.
Chengrui AnState Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, Fudan University, Shanghai, China.
Jun SuenagaCenter of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Yejie ShiCenter of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Yanqin GaoState Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, Fudan University, Shanghai, China.
Ping ZhengState Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, Fudan University, Shanghai, China.
Jun ChenCenter of Cerebrovascular Disease Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; State Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, Fudan University, Shanghai, China; Geriatric Research, Educational and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA 15240, USA. Electronic address: chenj2@upmc.edu.

Funding

Stress Proteins and Neuroprotection Against Parkinsonian Cell DeathP01NS059806 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHU, CHARLEEN T · 2009 to 2013
$6.3M
INDUCIBLE DNA REPAIR IN CEREBRAL ISCHEMIAR01NS036736 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BENNETT, MICHAEL V L, GRAHAM, STEVEN H · 1997 to 2021
$5.4M
Neuroprotection in Models of Cerebral IschemiaR01NS045048 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHEN, JUN · 2003 to 2015
$3.1M
Neuroprotection Against Parkinsonian Cell DeathR01NS062157 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHEN, JUN · 2010 to 2014
$1.5M
Neuroprotective effect of HSP27 in Cerebral IschemiaR01NS056118 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHEN, JUN · 2006 to 2010
$1.5M
NINDS NIH HHS NS36736NINDS NIH HHS NS45048NINDS NIH HHS NS59806NINDS NIH HHS NS62157NINDS NIH HHS P01 NS059806NINDS NIH HHS R01 NS036736NINDS NIH HHS R01 NS045048NINDS NIH HHS R01 NS056118NINDS NIH HHS R01 NS062157
6 · The paper itself

Abstract

Microglia are the first line of immune defense against central nervous system (CNS) injuries and disorders. These highly plastic cells play dualistic roles in neuronal injury and recovery and are known for their ability to assume diverse phenotypes. A broad range of surface receptors are expressed on microglia and mediate microglial 'On' or 'Off' responses to signals from other host cells as well as invading microorganisms. The integrated actions of these receptors result in tightly regulated biological functions, including cell mobility, phagocytosis, the induction of acquired immunity, and trophic factor/inflammatory mediator release. Over the last few years, significant advances have been made toward deciphering the signaling mechanisms related to these receptors and their specific cellular functions. In this review, we describe the current state of knowledge of the surface receptors involved in microglial activation, with an emphasis on their engagement of distinct functional programs and their roles in CNS injuries. It will become evident from this review that microglial homeostasis is carefully maintained by multiple counterbalanced strategies, including, but not limited to, 'On' and 'Off' receptor signaling. Specific regulation of theses microglial receptors may be a promising therapeutic strategy against CNS injuries.

Indexed as

AnimalsCentral Nervous SystemHumansMicrogliaReceptors, Cell SurfaceReceptors, ChemokineReceptors, Pattern RecognitionReceptors, PurinergicTrauma, Nervous Systemphosphatidylserine receptorReceptors, Cell SurfaceReceptors, ChemokineReceptors, Pattern RecognitionReceptors, PurinergicCentral nervous system injuriesMicrogliaReceptor

Identifiers

PMID24923657
PMCPMC4121732

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.