ArticleBiological psychiatry2015
Event-related potential and time-frequency endophenotypes for schizophrenia and psychotic bipolar disorder.
Article in Biological psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed.
- Volume and Tempo: Cortical Excitability and Trial-to-Trial Consistency of Auditory Responses Distinguish Psychosis Biotypes.Research square · 2026Article
- Brain Age Disparities in Psychosis Across DSM Diagnoses and B-SNIP Biotypes.Schizophrenia bulletin · 2026Article
- Schizophrenia endophenotypes: a review of neurophysiological, neuropsychological, and social cognition markers.Frontiers in psychiatry · 2026Review
- Differentiating biomarker features and familial characteristics of B-SNIP psychosis Biotypes.Translational psychiatry · 2025Article
- The visual evoked potential is a sensitive and powerful measure of experience-dependent visual cortical plasticity in mice.Current opinion in neurobiology · 2025Review
- Genetic analysis of psychosis Biotypes: shared Ancestry-adjusted polygenic risk and unique genomic associations.Molecular psychiatry · 2025Article
- Genetic Analysis of Psychosis Biotypes: Shared Ancestry-Adjusted Polygenic Risk and Unique Genomic Associations.medRxiv : the preprint server for health sciences · 2024Article
- Categorical and Dimensional Approaches for Psychiatric Classification and Treatment Targeting: Considerations from Psychosis Biotypes.Advances in neurobiology · 2024Review
- Event-related theta and gamma band oscillatory dynamics during visuo-spatial sequence memory in younger and older adults.PloS one · 2024Article
- Double dissociation between P300 components and task switch error type in healthy but not psychosis participants.Schizophrenia research · 2023Article
- Clinical characterization and differentiation of B-SNIP psychosis Biotypes: Algorithmic Diagnostics for Efficient Prescription of Treatments (ADEPT)-1.Schizophrenia research · 2023Article
- Emotional scene processing in biotypes of psychosis.Psychiatry research · 2023Article
- A machine learning approach on whole blood immunomarkers to identify an inflammation-associated psychosis onset subgroup.Molecular psychiatry · 2023Article
- Neuropsychiatric feature-based subgrouping reveals neural sensory processing spectrum in female FMR1 premutation carriers: A pilot study.Frontiers in integrative neuroscience · 2023Article
- Impaired dynamic functional brain properties and their relationship to symptoms in never treated first-episode patients with schizophrenia.Schizophrenia (Heidelberg, Germany) · 2022Article
- Event-related potential correlates of affective response inhibition in bipolar I disorder: Comparison with schizophrenia.Journal of affective disorders · 2022Article
- Temporal and time-frequency features of auditory oddball response in distinct subtypes of patients at clinical high risk for psychosis.European archives of psychiatry and clinical neuroscience · 2022Article
- Psychosis Biotypes: Replication and Validation from the B-SNIP Consortium.Schizophrenia bulletin · 2022Article
- Neural response to repeated auditory stimuli and its association with early language ability in male children with Fragile X syndrome.Frontiers in integrative neuroscience · 2022Article
- Reduced white matter microstructure in bipolar disorder with and without psychosis.Bipolar disorders · 2021Article
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Abstract
backgroundThe investigators compared event-related potential (ERP) amplitudes and event-related oscillations across a broad frequency range during an auditory oddball task using a comprehensive analysis approach to describe shared and unique neural auditory processing characteristics among healthy subjects (HP), schizophrenia probands (SZ) and their first-degree relatives, and bipolar disorder I with psychosis probands (BDP) and their first-degree relatives.
methodsThis Bipolar-Schizophrenia Network on Intermediate Phenotypes sample consisted of clinically stable SZ (n = 229) and BDP (n = 188), HP (n = 284), first-degree relatives of schizophrenia probands (n = 264), and first-degree relatives of bipolar disorder I with psychosis probands (n = 239). They were administered an auditory oddball task in the electroencephalography environment. Principal components analysis derived data-driven frequency bands evoked power. Spatial principal components analysis reduced ERP and frequency data to component waveforms for each subject. Clusters of time bins with significant group differences on response magnitude were assessed for proband/relative differences from HP and familiality.
resultsNine variables survived a linear discriminant analysis between HP, SZ, and BDP. Of those, two showed evidence (deficit in relatives and familiality) as genetic risk markers more specific to SZ (N1, P3b), one was specific to BDP (P2) and one for psychosis in general (N2).
conclusionsThis study supports for both shared and unique deficits in early sensory and late cognitive processing across psychotic diagnostic groups. Additional ERP and time-frequency component alterations (frontal N2/P2, late high, early, mid, and low frequency) may provide insight into deficits in underlying neural architecture and potential protective/compensatory mechanisms in unaffected relatives.
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