ArticleMolecular diagnosis & therapy2014
Blood-based biomarkers in depression: emerging themes in clinical research.
Article in Molecular diagnosis & therapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- A Preliminary Study of Adjunctive Nonconvulsive Electrotherapy for Treatment-Refractory Depression.The Psychiatric quarterly · 2021Trial
- Neurocognitive effects of ketamine and association with antidepressant response in individuals with treatment-resistant depression: a randomized controlled trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Trial
- Treatment effects on sphingosine-1-phosphate and its receptors in major depressive disorder: implications for biomarkers.BMC psychiatry · 2026Article
- Mitochondrial Metabolism in Major Depressive Disorder: From Early Diagnosis to Emerging Treatment Options.Journal of clinical medicine · 2024Review
- Plasma Neurotrophic Factor Levels are not Associated with the Severity of Depression: Prospective Pilot Study.Consortium psychiatricum · 2021Article
- Article
- DNA Methylation of the t-PA Gene Differs Between Various Immune Cell Subtypes Isolated From Depressed Patients Receiving Electroconvulsive Therapy.Frontiers in psychiatry · 2020Article
- Gene expression-based biological test for major depressive disorder: an advanced study.Neuropsychiatric disease and treatment · 2017Article
- Is there Progress? An Overview of Selecting Biomarker Candidates for Major Depressive Disorder.Frontiers in psychiatry · 2016Review
- Translational Shifts in Preclinical Models of Depression: Implications for Biomarkers for Improved Treatments.Current topics in behavioral neurosciencesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is growing interest in identifying blood-based biomarkers for depression. This brief review examines recent research in this area, using a focused literature search to identify emerging themes in current work pertaining to major depressive disorder (MDD). The results suggest that biomarker-based research in MDD is still in its relative infancy and is focused on answering two major questions: what biomarkers reliably distinguish individuals with MDD from those without MDD; and what biomarkers can identify or predict treatment responders versus non-responders? However, a number of issues limit the potential utility of positive findings in each case; chief among these is the lack of truly independent replication cohorts in which to validate initial findings. Some promising results have emerged pertaining to predictors of antidepressant effectiveness and, if validated by future independent studies, these may hold promise as targets to be developed within clinical settings and may ultimately guide treatment regimens for patients suffering from MDD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.