ArticleThe journal of physiological sciences : JPS2014
The effect of regular exercise on antioxidant enzyme activities and lipid peroxidation levels in both hippocampi after occluding one carotid in rat.
Article in The journal of physiological sciences : JPS, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 21 citations in OpenAlex.
- Melatonin attenuates cerebral hypoperfusion-induced hippocampal damage and memory deficits in rats by suppressing TRPM7 channels.Saudi journal of biological sciences · 2022Article
- Chronic administration of plasma from exercised rats to sedentary rats does not induce redox and metabolic adaptations.The journal of physiological sciences : JPS · 2020Article
- The effects of moderate exercise and overtraining on learning and memory, hippocampal inflammatory cytokine levels, and brain oxidative stress markers in rats.The journal of physiological sciences : JPS · 2019Article
- Effects of Levothyroxine on Visual Evoked Potential Impairment Following Local Injections of Lysolecithin into the Rat Optic Chiasm.International journal of preventive medicine · 2018Article
- Effects of doxepin on gene expressions of Bcl-2 family, TNF-α, MAP kinase 14, and Akt1 in the hippocampus of rats exposed to stress.Research in pharmaceutical sciences · 2017Article
- Effects of acute doses of methylphenidate on inflammation and oxidative stress in isolated hippocampus and cerebral cortex of adult rats.Journal of neural transmission (Vienna, Austria : 1996) · 2017Article
- The Effect of Levothyroxine on Serum Levels of Interleukin 10 and Interferon-gamma in Rat Model of Multiple Sclerosis.Advanced biomedical research · 2017Article
- The role of erythropoietin in remote renal preconditioning on hippocampus ischemia/reperfusion injury.The journal of physiological sciences : JPS · 2017Article
- Pre-ischemic exercise reduces apoptosis in hippocampal CA3 cells after cerebral ischemia by modulation of the Bax/Bcl-2 proteins ratio and prevention of caspase-3 activation.The journal of physiological sciences : JPS · 2015Article
- Novel applications of trophic factors, Wnt and WISP for neuronal repair and regeneration in metabolic disease.Neural regeneration research · 2015Review
- FoxO proteins in the nervous system.Analytical cellular pathology (Amsterdam) · 2015Review
- New Insights for Oxidative Stress and Diabetes Mellitus.Oxidative medicine and cellular longevity · 2015Review
- Programming apoptosis and autophagy with novel approaches for diabetes mellitus.Current neurovascular research · 2015Review
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regular exercise has beneficial effects on cerebrovascular diseases; however, its biochemical mechanisms are not fully known. The purpose of this study was to determine antioxidant enzyme activities and lipid peroxidation of both hippocampi after applying exercise followed by occluding one common carotid. Wistar rats were divided into four groups of control, exercise, hypoperfusion and exercise-hypoperfusion (exe-hypo). In the exercise and exe-hypo groups, the rats were forced to run on a treadmill for 1 h a day for 2 months. The right common carotid of the animals in the (exe-hypo) group was occluded after the cessation of exercise. Surgery without occlusion of the carotid was applied on the control (without exercise) and exercise groups. All animals were sacrificed 1 and 24 h after surgery. The levels of malondialdehyde (MDA) and antioxidant enzyme activities in the hippocampi were measured. A significant interaction was observed between the exercise and hypoperfusion in both hippocampi (p<0.05). In comparison with the control group, there was significant elevation of catalase activity in the right and left hippocampus of the hypo group at 24 h (p<0.0001). Regarding the differences between the hemispheres, there was a significant increase in MDA and decrease in catalase activity in the left hippocampus in hypoperfusion group, but the exercise in the exe-hypo group succeeded in abolishing these alterations which were caused by hypoperfusion, This study shows that exercise pre-conditioning prevents some alterations in brain oxidant-antioxidant status which are induced by cerebral hypoperfusion. Further studies are needed in order to clarify the mechanism of exercise.
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