ArticleGenome biology and evolution2014
Evolutionary origin and methylation status of human intronic CpG islands that are not present in mouse.
Article in Genome biology and evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Dissection of the gene regulatory network underlying sexual maturity divergence in Jining Bairi chickens through integrated RNA-seq and WGCNA analysis.Poultry science · 2025Article
- No indications of weight gain associated DNA methylation changes in patients with anorexia nervosa.Scientific reports · 2025Article
- Circulating cell-free methylated DNA reveals tissue-specific, cellular damage from radiation treatment.JCI insight · 2023Article
- No evidence for intervention-associated DNA methylation changes in monocytes of patients with posttraumatic stress disorder.Scientific reports · 2022Article
- IGF2R-initiated proton rechanneling dictates an anti-inflammatory property in macrophages.Science advances · 2020Article
- A genome-wide search for new imprinted genes in the human placenta identifies DSCAM as the first imprinted gene on chromosome 21.European journal of human genetics : EJHG · 2019Article
- Regions of common inter-individual DNA methylation differences in human monocytes: genetic basis and potential function.Epigenetics & chromatin · 2017Article
- Genome-wide methylation analysis of retrocopy-associated CpG islands and their genomic environment.Epigenetics · 2016Article
- Allelic expression of mammalian imprinted genes in a matrotrophic lizard, Pseudemoia entrecasteauxii.Development genes and evolution · 2016Article
- Epigenetic dynamics of monocyte-to-macrophage differentiation.Epigenetics & chromatin · 2016Article
- Genome-wide methylation analysis in Silver-Russell syndrome patients.Human genetics · 2015Article
- Stat3 is a candidate epigenetic biomarker of perinatal Bisphenol A exposure associated with murine hepatic tumors with implications for human health.Epigenetics · 2015Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Imprinting of the human RB1 gene is due to the presence of a differentially methylated CpG island (CGI) in intron 2, which is part of a retrocopy derived from the PPP1R26 gene on chromosome 9. The murine Rb1 gene does not have this retrocopy and is not imprinted. We have investigated whether the RB1/Rb1 locus is unique with respect to these differences. For this, we have compared the CGIs from human and mouse by in silico analyses. We have found that the human genome does not only contain more CGIs than the mouse, but the proportion of intronic CGIs is also higher (7.7% vs. 3.5%). At least 2,033 human intronic CGIs are not present in the mouse. Among these CGIs, 104 show sequence similarities elsewhere in the human genome, which suggests that they arose from retrotransposition. We could narrow down the time points when most of these CGIs appeared during evolution. Their methylation status was analyzed in two monocyte methylome data sets from whole-genome bisulfite sequencing and in 18 published methylomes. Four CGIs, which are located in the RB1, ASRGL1, PARP11, and PDXDC1 genes, occur as methylated and unmethylated copies. In contrast to imprinted methylation at the RB1 locus, differential methylation of the ASRGL1 and PDXDC1 CGIs appears to be sequence dependent. Our study supports the notion that the epigenetic fate of the retrotransposed DNA depends on its sequence and selective forces at the integration site.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.