Evidence map›Paper›PMID 24922572›Full record

ArticleCell host & microbe2014

Circulating avian influenza viruses closely related to the 1918 virus have pandemic potential.

Tokiko Watanabe, Gongxun Zhong, Colin A Russell, Noriko Nakajima, Masato Hatta, Anthony Hanson, Ryan McBride, David F Burke, Kenta Takahashi, Satoshi Fukuyama and 9 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell host & microbe, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
9.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 78 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. The 1918 Influenza Pandemic and Its Legacy.Cold Spring Harbor perspectives in medicine · 2020
    Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Back to the Future: Lessons Learned From the 1918 Influenza Pandemic.Frontiers in cellular and infection microbiology · 2018
    Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 3 countries.

Tokiko WatanabeDepartment of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 575 Science Drive, Madison, WI 53711, USA; ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama 332-0012, Japan.
Gongxun ZhongDepartment of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 575 Science Drive, Madison, WI 53711, USA.
Colin A RussellDepartment of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK.
Noriko NakajimaDepartment of Pathology, National Institute of Infectious Diseases, Shinjuku, Tokyo 162-8640, Japan.
Masato HattaDepartment of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 575 Science Drive, Madison, WI 53711, USA.
Anthony HansonDepartment of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 575 Science Drive, Madison, WI 53711, USA.
Ryan McBrideDepartment of Cell and Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
David F BurkeDepartment of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK.
Kenta TakahashiDepartment of Pathology, National Institute of Infectious Diseases, Shinjuku, Tokyo 162-8640, Japan.
Satoshi FukuyamaERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama 332-0012, Japan.
Yuriko TomitaERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama 332-0012, Japan.
Eileen A MaherDepartment of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 575 Science Drive, Madison, WI 53711, USA.
Shinji WatanabeERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama 332-0012, Japan; Laboratory of Veterinary Microbiology, Department of Veterinary Sciences, University of Miyazaki, Miyazaki 889-2192, Japan.
Masaki ImaiDepartment of Veterinary Medicine, Faculty of Agriculture, Iwate University, Iwate 020-8550, Japan; Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo 208-0011, Japan.
Gabriele NeumannDepartment of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 575 Science Drive, Madison, WI 53711, USA.
Hideki HasegawaDepartment of Pathology, National Institute of Infectious Diseases, Shinjuku, Tokyo 162-8640, Japan.
James C PaulsonDepartment of Cell and Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Derek J SmithDepartment of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK.
Yoshihiro KawaokaDepartment of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 575 Science Drive, Madison, WI 53711, USA; ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama 332-0012, Japan; Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan; Department of Special Pathogens, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan. Electronic address: kawaokay@svm.vetmed.wisc.edu.
University of Wisconsin–Madison · USNational Institute of Infectious Diseases · JPUniversity of Cambridge · GBJapan Science and Technology Agency · JPScripps Research Institute · USUniversity of Miyazaki · JP

Funding

Structural Basis of Immune Recognition of Glycosylated AntigensU54GM062116 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI HEAD, STEVEN R · 2001 to 2010
$80.3M
Virology Training ProgramT32AI078985 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI LAMBERT, PAUL F. · 2009 to 2018
$3.3M
Molecular Mechanisms for the High Pathogenicity of 1918 Influenza VirusR01AI080598 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KAWAOKA, YOSHIHIRO · 2009 to 2013
$3.2M
Structural insights into pandemic and emerging influenza virusesR56AI099275 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI WILSON, IAN A · 2013 to 2013
$823k
NIAID NIH HHS R01 AI080598NIAID NIH HHS R56 AI099275NIAID NIH HHS T32 AI078985NIGMS NIH HHS U54 GM062116Wellcome Trust 100891
6 · The paper itself

Abstract

Wild birds harbor a large gene pool of influenza A viruses that have the potential to cause influenza pandemics. Foreseeing and understanding this potential is important for effective surveillance. Our phylogenetic and geographic analyses revealed the global prevalence of avian influenza virus genes whose proteins differ only a few amino acids from the 1918 pandemic influenza virus, suggesting that 1918-like pandemic viruses may emerge in the future. To assess this risk, we generated and characterized a virus composed of avian influenza viral segments with high homology to the 1918 virus. This virus exhibited pathogenicity in mice and ferrets higher than that in an authentic avian influenza virus. Further, acquisition of seven amino acid substitutions in the viral polymerases and the hemagglutinin surface glycoprotein conferred respiratory droplet transmission to the 1918-like avian virus in ferrets, demonstrating that contemporary avian influenza viruses with 1918 virus-like proteins may have pandemic potential.

Indexed as

Amino Acid SubstitutionAnimalsAntiviral AgentsBiological EvolutionBirdsDisease Models, AnimalDogsFemaleFerretsHumansInfluenza A virusInfluenza, HumanInfluenza in BirdsInfluenza VaccinesMadin Darby Canine Kidney CellsMice, Inbred BALB CAntiviral AgentsInfluenza VaccinesPB2 protein, influenza virusViral Proteins

Identifiers

PMID24922572
PMCPMC4205238
OpenAlexW2062869652

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.