Evidence map›Paper›PMID 24922570›Full record

ReviewCell host & microbe2014

Advances in norovirus biology.

Stephanie M Karst, Christiane E Wobus, Ian G Goodfellow, Kim Y Green, Herbert W Virgin

Abstract readReview
In one paragraph

Review in Cell host & microbe, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers.

0numbers the graph read from it
0cells of the map it votes in
126citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

126 citing papers in PubMed.

  1. Review
  2. Plscr1 inhibits murine norovirus entry.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
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  8. Article
  9. Review
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  11. Article
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  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article

66 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Stephanie M KarstCollege of Medicine, Department of Molecular Genetics and Microbiology, Emerging Pathogens Institute, University of Florida, Gainesville, FL 32610, USA.
Christiane E WobusDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Ian G GoodfellowDivision of Virology, Department of Pathology, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK.
Kim Y GreenLaboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Herbert W VirginDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: virgin@wustl.edu.

Funding

Genetic and Pathway Analysis CoreU19AI109725 · NIAID · WASHINGTON UNIVERSITY · PI VIRGIN, HERBERT W · 2014 to 2018
$32.7M
Noroviruses and Epidemic GastroenteritisZIAAI000897 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI GREEN, KIM Y. · 2009 to 2025
$29.6M
IMMUNITY AND PATHOGENESIS OF A NOVEL NOROVIRUSR01AI054483 · NIAID · WASHINGTON UNIVERSITY · PI VIRGIN, HERBERT W · 2003 to 2012
$3.7M
SUSCEPTIBILILTY GENE-VIRUS INTERACTIONS IN INFLAMMATORY BOWEL DISEASER01AI084887 · NIAID · WASHINGTON UNIVERSITY · PI STAPPENBECK, THADDEUS S, VIRGIN, HERBERT W · 2010 to 2014
$1.9M
Mechanisms of Norovirus EntryR01AI080611 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WOBUS, CHRISTIANE · 2009 to 2012
$1.5M
Subversion of gastrointestinal host defenses by norovirusR21AI103961 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WOBUS, CHRISTIANE · 2013 to 2014
$428k
NIAID NIH HHS R01 AI054483NIAID NIH HHS R01 AI080611NIAID NIH HHS R01 AI084887NIAID NIH HHS R21 AI103961NIAID NIH HHS U19 AI109725Wellcome Trust 097997
6 · The paper itself

Abstract

Human noroviruses are a major cause of epidemic and sporadic gastroenteritis worldwide and can chronically infect immunocompromised patients. Efforts to develop effective vaccines and antivirals have been hindered by the uncultivable nature and extreme genetic diversity of human noroviruses. Although they remain a particularly challenging pathogen to study, recent advances in norovirus animal models and in vitro cultivation systems have led to an increased understanding of norovirus molecular biology and replication, pathogenesis, cell tropism, and innate and adaptive immunity. Furthermore, clinical trials of vaccines consisting of nonreplicating virus-like particles have shown promise. In this review, we summarize these recent advances and discuss controversies in the field, which is rapidly progressing toward generation of antiviral agents and increasingly effective vaccines.

Indexed as

Antiviral AgentsCaliciviridae InfectionsGastroenteritisHost-Pathogen InteractionsHumansImmunity, HumoralNorovirusViral VaccinesAntiviral AgentsViral Vaccines

Identifiers

PMID24922570
PMCPMC4113907

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.