Evidence map›Paper›PMID 24922517›Full record

ArticlePloS one2014

Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.

Valentina Escott-Price, Céline Bellenguez, Li-San Wang, Seung-Hoan Choi, Denise Harold, Lesley Jones, Peter Holmans, Amy Gerrish, Alexey Vedernikov, Alexander Richards and 180 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 3 pooled it
103.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 3 syntheses or guidelines pooled it, 1,405 citations in OpenAlex.

  1. Pooled it
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  4. Trial
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12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

190 authors at 20 institutions in 16 countries.

Valentina Escott-PriceInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
Céline BellenguezInserm U744, Lille, France; Université Lille 2, Lille, France; Institut Pasteur de Lille, Lille, France.
Li-San WangDepartment of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.
Seung-Hoan ChoiDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.
Denise HaroldInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
Lesley JonesInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
Peter HolmansInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
Amy GerrishInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
Alexey VedernikovInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
Alexander RichardsInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
Anita L DeStefanoDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.
Jean-Charles LambertInserm U744, Lille, France; Université Lille 2, Lille, France; Institut Pasteur de Lille, Lille, France.
Carla A Ibrahim-VerbaasDepartment of Epidemiology and Neurology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Adam C NajDepartment of Biostatistics and Epidemiology and Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
Rebecca SimsInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
Gyungah JunDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, United States of America; Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, United States of America.
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America.
Gary W BeechamThe John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, United States of America.
Benjamin Grenier-BoleyInserm U744, Lille, France; Université Lille 2, Lille, France; Institut Pasteur de Lille, Lille, France.
Giancarlo RussoFunctional Genomics Center Zurich, ETH/University of Zurich, Zurich, Switzerland.
Tricia A Thornton-WellsDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States of America.
Nicola DenningInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
Albert V SmithUniversity of Iceland, Faculty of Medicine, Reykjavik, Iceland; Icelandic Heart Association, Kopavogur, Iceland.
Vincent ChourakiInserm U744, Lille, France; Université Lille 2, Lille, France; Institut Pasteur de Lille, Lille, France; Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America.
Charlene ThomasInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
M Arfan IkramDepartments of Epidemiology, Neurology and Radiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands; Netherlands Consortium for Healthy Aging, Leiden, The Netherlands.
Diana ZelenikaCentre National de Genotypage, Institut Genomique, Commissariat à l'énergie Atomique, Evry, France.
Badri N VardarajanDepartment of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, United States of America; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University New York, New York, United States of America; Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York, United States of America.
Yoichiro KamataniFondation Jean Dausset- CEPH, Paris, France.
Chiao-Feng LinDepartment of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.
Helena SchmidtInstitute for Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
Brian KunkleThe John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America.
Melanie L DunstanInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
Maria VronskayaInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
United Kingdom Brain Expression Consortium
Andrew D JohnsonNHLBI Cardiovascular Epidemiology and Human Genomics Branch, The Framingham Heart Study, Framingham, Massachusetts, United States of America.
Agustin RuizMemory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain.
Marie-Thérèse BihoreauCentre National de Genotypage, Institut Genomique, Commissariat à l'énergie Atomique, Evry, France.
Christiane ReitzTaub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University New York, New York, United States of America; Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York, United States of America.
Florence PasquierUniversité Lille 2, Lille, France; CNR-MAJ, Centre Hospitalier Régional Universitaire de Lille, Lille, France.
Paul HollingworthInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
Olivier HanonUniversity Paris Descartes, Sorbonne Paris V, Broca Hospital, Geriatrics department, Paris, France.
Annette L FitzpatrickCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America; Departments of Epidemiology and Global Health, University of Washington, Seattle, Washington, United States of America.
Joseph D BuxbaumDepartment of Neuroscience, Mount Sinai School of Medicine, New York, New York, United States of America; Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, United States of America; Departments of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America.
Dominique CampionCNR-MAJ, Inserm U1079, Rouen University Hospital, 76031 France, Rouen, France.
Paul K CraneDepartment of Medicine, University of Washington, Seattle, Washington, United States of America.
Clinton BaldwinDepartment of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, United States of America.
Tim BeckerGerman Center for Neurodegenerative Diseases (DZNE), Bonn, and Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany.
Vilmundur GudnasonUniversity of Iceland, Faculty of Medicine, Reykjavik, Iceland; Icelandic Heart Association, Kopavogur, Iceland.
Carlos CruchagaDepartment of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, Missouri, United States of America.
David CraigAgeing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom.
Najaf AminDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Claudine BerrINSERM U1061, Faculty of Medicine, Hôpital La Colombière, Montpellier, France.
Oscar L LopezDepartments of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.
Philip L De JagerProgram in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology & Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America; Program in Medical and Population Genetics, Broad Institute, Boston, Massachusetts, United States of America.
Vincent DeramecourtUniversité Lille 2, Lille, France; CNR-MAJ, Centre Hospitalier Régional Universitaire de Lille, Lille, France.
Janet A JohnstonAgeing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom.
Denis EvansRush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, United States of America.
Simon LovestoneKing's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, United Kingom.
Luc LetenneurInserm U897, Victor Segalen University, F-33076, Bordeaux, France.
Isabel HernándezMemory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain.
David C RubinszteinCambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.
Gudny EiriksdottirIcelandic Heart Association, Kopavogur, Iceland.
Kristel SleegersNeurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium; Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
Alison M GoateDepartment of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Nathalie FiévetInserm U744, Lille, France; Institut Pasteur de Lille, Lille, France.
Matthew J HuentelmanNeurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, United States of America.
Michael GillDiscipline of Psychiatry, Trinity College, Dublin, Ireland.
Kristelle BrownInstitute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom.
M Ilyas KambohDepartment of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Lina KellerAging Reasearch Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Pascale Barberger-GateauKing's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, United Kingom.
Bernadette McGuinnessAgeing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom.
Eric B LarsonDepartment of Medicine, University of Washington, Seattle, Washington, United States of America; Group Health Research Institute, Group Health, Seattle, Washington, United States of America.
Amanda J MyersDepartment of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida, United States of America.
Carole DufouilInserm U897, Victor Segalen University, F-33076, Bordeaux, France.
Stephen ToddAgeing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom.
David WallonCNR-MAJ, Inserm U1079, Rouen University Hospital, 76031 France, Rouen, France.
Seth LoveUniversity of Bristol Institute of Clinical Neurosciences, School of Clinical Sciences, Frenchay Hospital, Bristol, United Kingdom.
Ekaterina RogaevaTanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada.
John GallacherInstitute of Primary Care and Public Health, Cardiff University, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff, United Kingdom.
Peter St George-HyslopTanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada; Cambridge Institute for Medical Research and Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
Jordi ClarimonNeurology Department. IIB Sant Pau. Sant Pau Hospital. Universitat Autònoma de Barcelona, Barcelona, Spain; Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona, Spain.
Alberto LleoNeurology Department. IIB Sant Pau. Sant Pau Hospital. Universitat Autònoma de Barcelona, Barcelona, Spain; Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona, Spain.
Anthony BayerInstitute of Primary Care and Public Health, Cardiff University, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff, United Kingdom.
Debby W TsuangDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, United States of America.
Lei YuDepartment of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, United States of America.
Magda Tsolaki3rd Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Paola BossùClinical and Behavioral Neurology, Fondazione Santa Lucia, Roma, Italy.
Gianfranco SpallettaClinical and Behavioral Neurology, Fondazione Santa Lucia, Roma, Italy.
Petra ProitsiKing's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, United Kingom.
John CollingeMRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom.
Sandro SorbiNEUROFARBA Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy; Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence, Italy.
Florentino Sanchez GarciaDepartment of Immunology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain.
Nick C FoxDementia Research Center, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom.
John HardyDepartment of Molecular Neuroscience and Reta Lilla Weston Laboratories, Institute of Neurology, London, United Kingdom.
Maria Candida Deniz NaranjoDepartment of Immunology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain.
Paolo BoscoIRCCS Associazione Oasi Maria SS, Troina, Italy.
Robert ClarkeOxford Healthy Aging Project (OHAP), Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom.
Carol BrayneCognitive Function and Ageing Study (CFAS), Institute of Public Health, University of Cambridge, Cambridge, United Kingdom.
Daniela GalimbertiUniversity of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan, Italy.
Elio ScarpiniUniversity of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan, Italy.
Ubaldo BonuccelliNeurological Clinic, University of Pisa, Pisa, Italy.
Michelangelo MancusoNeurological Clinic, University of Pisa, Pisa, Italy.
Gabriele SicilianoNeurological Clinic, University of Pisa, Pisa, Italy.
Susanne MoebusUrban Epidemiology, Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Patrizia MecocciSection of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy.
Maria Del ZompoSection of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Wolfgang MaierDepartment of Psychiatry and Psychotherapy, University of Bonn, Germany and German Center for Neurodegenerative Diseases (DZNE, Bonn), Bonn, Germany.
Harald HampelDepartment of Psychiatry, University of Frankfurt am Main, Frankfurt am Main, Germany (H.H.); Department of Psychiatry, Ludwig-Maximilians University, Munich, Germany.
Alberto PilottoGerontology and Geriatrics Research Laboratory, I.R.C.C.S. Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), Italy.
Ana Frank-GarcíaCentro de Biología Molecular Severo Ochoa (CSIC-UAM); Madrid, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain; Instituto de Investigación Sanitaria "Hospital la Paz" (IdIPaz), Madrid, Spain.
Francesco PanzaDepartment of Geriatrics,Center for Aging Brain,University of Bari, Bari, Italy.
Vincenzo SolfrizziDepartment of Geriatrics,Center for Aging Brain,University of Bari, Bari, Italy.
Paolo CaffarraDepartment of Neuroscience-University of Parma, Parma, Italy; Center for Cognitive Disorders AUSL, Parma, Italy.
Benedetta NacmiasNEUROFARBA Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy; Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence, Italy.
William PerryThe John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, United States of America.
Manuel MayhausDepartment Of Psychiatry, University Hospital, Saarland, Germany.
Lars LannfeltDepartment of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden.
Hakon HakonarsonCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.
Sabrina PichlerDepartment Of Psychiatry, University Hospital, Saarland, Germany.
Minerva M CarrasquilloDepartment of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America.
Martin IngelssonDepartment of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden.
Duane BeeklyNational Alzheimer's Coordinating Center, University of Washington, Seattle, Washington, United States of America.
Victoria AlvarezGenetica molecular-Huca-Oviedo, Oviedo, Spain.
Fanggeng ZouDepartment of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America.
Otto ValladaresDepartment of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.
Steven G YounkinDepartment of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America.
Eliecer CotoGenetica molecular-Huca-Oviedo, Oviedo, Spain.
Kara L Hamilton-NelsonThe John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America.
Wei GuDepartment of Psychiatry, University Hospital, Saarland, Germany.
Cristina RazquinNeurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra School of Medicine, Pamplona, Spain.
Pau PastorNeurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra School of Medicine, Pamplona, Spain; CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain.
Ignacio MateoNeurology Service and CIBERNED, "Marqués de Valdecilla" University Hospital (University of Cantabria and IFIMAV), Santander, Spain.
Michael J OwenInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
Kelley M FaberDepartment of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, United States of America.
Palmi V JonssonUniversity of Iceland, Faculty of Medicine, Reykjavik, Iceland; Landspitali University Hospital, Reykjavik, Iceland.
Onofre CombarrosNeurology Service and CIBERNED, "Marqués de Valdecilla" University Hospital (University of Cantabria and IFIMAV), Santander, Spain.
Michael C O'DonovanInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
Laura B CantwellDepartment of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.
Hilkka SoininenInstitute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland; Department of Neurology, Kuopio University Hospital, Kuopio, Finland.
Deborah BlackerDepartment of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America; Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, United States of America.
Simon MeadMRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom.
Thomas H MosleyDepartment of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, Mississippi, United States of America.
David A BennettDepartment of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, United States of America; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America.
Tamara B HarrisLaboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, Maryland, United States of America.
Laura FratiglioniAging Research Center, Department Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden; Department Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge, Stockholm, Sweden.
Clive HolmesDivision of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, United Kingdom.
Renee F A G de BruijnDepartments of Neurology and Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Peter PassmoreAgeing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom.
Thomas J MontineDepartment of Pathology, University of Washington, Seattle, Washington, United States of America.
Karolien BettensNeurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium; Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, United States of America.
Alexis BriceINSERM UMR_S975-CNRS UMR 7225, Université Pierre et Marie Curie, Centre de recherche de l'Institut du Cerveau et de la Moëlle épinière-CRICM, Hôpital de la Salpêtrière, Paris France; AP-HP, Hôpital de la Pitié-Salpêtrière, Paris, France.
Kevin MorganInstitute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom.
Tatiana M ForoudDepartment of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, United States of America.
Walter A KukullDepartment of Epidemiology, University of Washington, Seattle, Washington, United States of America.
Didier HannequinCNR-MAJ, Inserm U1079, Rouen University Hospital, 76031 France, Rouen, France.
John F PowellKing's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, United Kingom.
Michael A NallsLaboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America.
Karen RitchieINSERM U1061, Faculty of Medicine, Hôpital La Colombière, Montpellier, France; Imperial College, London, United Kingdom.
Kathryn L LunettaDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.
John S K KauweDepartment of Biology, Brigham Young University, Provo, Utah, United States of America.
Eric BoerwinkleHuman Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America; Human Genetics Center and Div. of Epidemiology, University of Texas Health Sciences Center at Houston, Houston, Texas, United States of America.
Matthias RiemenschneiderDepartment of Psychiatry, University Hospital, Saarland, Germany.
Mercè BoadaMemory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain; Hospital Universitari Vall d'Hebron - Institut de Recerca, Universitat Autònoma de Barcelona. (VHIR-UAB), Barcelona, Spain.
Mikko HiltunenInstitute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland; Department of Neurology, Kuopio University Hospital, Kuopio, Finland.
Eden R MartinThe John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, United States of America.
Reinhold SchmidtDepartment of Neurology, Medical University Graz, Graz, Austria.
Dan RujescuDepartment of Psychiatry, Ludwig-Maximilians University, Munich, Germany.
Jean-François DartiguesInserm U897, Victor Segalen University, F-33076, Bordeaux, France; Centre de Mémoire de Ressources et de Recherche de Bordeaux, CHU de Bordeaux, Bordeaux, France.
Richard MayeuxTaub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University New York, New York, United States of America; Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York, United States of America.
Christophe TzourioInserm U708, Victor Segalen University, Bordeaux, France.
Albert HofmanDepartments of Epidemiology, Neurology and Radiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands; Netherlands Consortium for Healthy Aging, Leiden, The Netherlands.
Markus M NöthenInstitute of Human Genetics, Department of Genomics, Life and Brain Center, University of Bonn, and German Center for Neurodegenerative Diseases (DZNE, Bonn), Bonn, Germany.
Caroline GraffDepartment Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge, Stockholm, Sweden; Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, KIADRC, Stockholm, Sweden.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America; Group Health Research Institute, Group Health Cooperative, Seattle, Washington, United States of America.
Jonathan L HainesVanderbilt Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America; Department of Epidemiology & Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America.
Mark LathropDepartment of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, United States of America; Fondation Jean Dausset- CEPH, Paris, France; McGill University and Génome Québec Innovation Centre, Montreal, Canada.
Margaret A Pericak-VanceThe John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, United States of America.
Lenore J LaunerLaboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, Maryland, United States of America.
Christine Van BroeckhovenNeurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium; Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
Lindsay A FarrerDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, United States of America; Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, United States of America; Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, United States of America; Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America.
Cornelia M van DuijnNetherlands Consortium for Healthy Aging, Leiden, The Netherlands; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands; Center for Medical Systems Biology, Leiden, The Netherlands.
Alfredo RamirezDepartment of Psychiatry and Psychotherapy and Institute of Human Genetics, University of Bonn, Bonn, Germany.
Sudha SeshadriDepartment of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America; The Framingham Heart Study, Framingham, Massachusetts, United States of America.
Gerard D SchellenbergDepartment of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.
Philippe AmouyelInserm U744, Lille, France; Université Lille 2, Lille, France; Institut Pasteur de Lille, Lille, France; CNR-MAJ, Centre Hospitalier Régional Universitaire de Lille, Lille, France; Centre Hospitalier Régional Universitaire de Lille, Lille, France.
Julie WilliamsInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
Cardiovascular Health Study (CHS)
Cardiff University · GBBoston University · USInserm · FRUniversity of Washington · USUniversity of Pennsylvania · USQueen's University Belfast · GBErasmus MC · NLKing's College London · GBSaarland University · DEUniversity of Miami · USDr. John T. Macdonald Foundation · USInstitut Pasteur de Lille · FRMayo Clinic in Florida · USRush University Medical Center · USUniversity of Bonn · DEUniversity of Pisa · ITBiomedical Research Networking Center on Neurodegenerative Diseases · ESColumbia University · USFondazione Santa Lucia · ITFundació ACE · ES

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8M
TRIAL OF VALPROATE TO ATTENUATE THE PROGRESSION OF ADU01AG010483 · NIA · UNIVERSITY OF ROCHESTER · PI AISEN, PAUL S. · 1991 to 2012
$116.2M
Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
NATIONAL ALZHEIMERS COORDINATING CENTER (NACC)U01AG016976 · NIA · UNIVERSITY OF WASHINGTON · PI KUKULL, WALTER ANTHONY · 1999 to 2020
$72.8M
Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI Tammie Lee Smith Benzinger · 1985 to 2026
$69.5M
TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
Alzheimer's Disease Genetics ConsortiumU01AG032984 · NIA · UNIVERSITY OF PENNSYLVANIA · PI SCHELLENBERG, GERARD DAVID · 2009 to 2024
$60.4M
THERAPEUTIC EFFECTS OF INTRA-NASAL INSULIN DETEMIRP50AG005136 · NIA · UNIVERSITY OF WASHINGTON · PI JAYADEY, SUMAN · 1985 to 2019
$57.2M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
VIRUS-INDUCED BRAIN PATHOLOGYP50AG005131 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BREWER, JAMES B · 1985 to 2018
$55.4M
WASHINGTON UNIVERSITY ALZHEIMERS DISEASE RESEARCH CENTERP50AG005681 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 1985 to 2019
$52.1M
Medical Research Council G0902227Medical Research Council MC_U123160651Medical Research Council MC_U123192748Medical Research Council MC_U137686857Medical Research Council MR/K013041/1Medical Research Council MR/L010305/1Medical Research Council MR/L501517/1NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001108NCI NIH HHS R01 CA129769NCRR NIH HHS M01 RR000096NCRR NIH HHS UL1 RR025005NCRR NIH HHS UL1 RR029893NHGRI NIH HHS U01 HG004402NHGRI NIH HHS U01 HG004610NHGRI NIH HHS U01 HG006375NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HL080295NHLBI NIH HHS HL087652NHLBI NIH HHS HL093029NHLBI NIH HHS HL105756NHLBI NIH HHS K24HL038444NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC055015NHLBI NIH HHS N01 HC055016NHLBI NIH HHS N01 HC055018NHLBI NIH HHS N01 HC055019NHLBI NIH HHS N01 HC055020NHLBI NIH HHS N01 HC055021NHLBI NIH HHS N01 HC055022NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS R01 HL080295NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL093029NHLBI NIH HHS R01 HL096917NHLBI NIH HHS R01 HL105756NHLBI NIH HHS RC2 HL102419NHLBI NIH HHS RC2-HL102419NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL096917NHLBI NIH HHS UC2 HL103NHLBI NIH HHS UC2 HL103010NIA NIH HHS AG010491NIA NIH HHS AG019757NIA NIH HHS AG021547NIA NIH HHS AG023629NIA NIH HHS AG027058NIA NIH HHS AG027944NIA NIH HHS AG030653NIA NIH HHS AG033193NIA NIH HHS AG034504NIA NIH HHS AG041718NIA NIH HHS AG08122NIA NIH HHS AG15928NIA NIH HHS AG20098NIA NIH HHS K01 AG030514NIA NIH HHS N01 AG012100NIA NIH HHS N01-AG-12100NIA NIH HHS P01 AG002219NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG010491NIA NIH HHS P01 AG019724NIA NIH HHS P01 AG03991NIA NIH HHS P30 AG008017NIA NIH HHS P30 AG008051NIA NIH HHS P30 AG010124NIA NIH HHS P30 AG010129NIA NIH HHS P30 AG010133NIA NIH HHS P30 AG010161NIA NIH HHS P30 AG012300NIA NIH HHS P30 AG013846NIA NIH HHS P30 AG013854NIA NIH HHS P30 AG019610NIA NIH HHS P30 AG028377NIA NIH HHS P30 AG028383NIA NIH HHS P50 AG005128NIA NIH HHS P50 AG005131NIA NIH HHS P50 AG005133NIA NIH HHS P50AG005133NIA NIH HHS P50 AG005134NIA NIH HHS P50 AG005136NIA NIH HHS P50 AG005138NIA NIH HHS P50 AG005142NIA NIH HHS P50 AG005146NIA NIH HHS P50 AG005681NIA NIH HHS P50 AG008671NIA NIH HHS P50 AG008671;NIA NIH HHS P50 AG008702NIA NIH HHS P50 AG016570NIA NIH HHS P50 AG016573NIA NIH HHS P50 AG016574NIA NIH HHS P50 AG016582NIA NIH HHS P50 AG023501NIA NIH HHS P50 AG025688NIA NIH HHS R01 AG008122NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG015928NIA NIH HHS R01 AG016495NIA NIH HHS R01 AG017173NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG019085NIA NIH HHS R01 AG019757NIA NIH HHS R01 AG020098NIA NIH HHS R01 AG020688NIA NIH HHS R01 AG021547NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG025259NIA NIH HHS R01 AG026916NIA NIH HHS R01 AG027058NIA NIH HHS R01 AG027944NIA NIH HHS R01 AG030146NIA NIH HHS R01 AG030653NIA NIH HHS R01 AG031287NIA NIH HHS R01 AG031581NIA NIH HHS R01 AG033040NIA NIH HHS R01 AG033193NIA NIH HHS R01 AG034504NIA NIH HHS R01 AG037212NIA NIH HHS R01 AG041232NIA NIH HHS R01 AG041718NIA NIH HHS R01 AG041797NIA NIH HHS R37 AG015473NIA NIH HHS R56 AG020098NIA NIH HHS R56 AG023629NIA NIH HHS RC2 AG036528NIA NIH HHS RC2 AG036535NIA NIH HHS RF1 AG015819NIA NIH HHS U01 AG006781NIA NIH HHS U01 AG010483NIA NIH HHS U01 AG016976NIA NIH HHS U01 AG024904NIA NIH HHS U01 AG032984NIA NIH HHS U01 AG049505NIA NIH HHS U24 AG021886NIA NIH HHS U24 AG026395NIA NIH HHS U24 AG056270NIDDK NIH HHS DK063491NIDDK NIH HHS P30 DK063491NIGMS NIH HHS T32 GM008151NIMH NIH HHS MH60451NIMH NIH HHS P50 MH060451NIMH NIH HHS R01 MH080295NINDS NIH HHS NS39764NINDS NIH HHS P50 NS039764NINDS NIH HHS R01 NS017950NINDS NIH HHS R01 NS059873Wellcome Trust 081864Wellcome Trust 089703Wellcome Trust 095317Wellcome Trust 100140
6 · The paper itself

Abstract

backgroundAlzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an alternative gene-wide analytical approach which tests for patterns of association within genes, in the powerful genome-wide association dataset of the International Genomics of Alzheimer's Project Consortium, comprising over 7 m genotypes from 25,580 Alzheimer's cases and 48,466 controls. PRINCIPAL

findingsIn addition to earlier reported genes, we detected genome-wide significant loci on chromosomes 8 (TP53INP1, p = 1.4×10-6) and 14 (IGHV1-67 p = 7.9×10-8) which indexed novel susceptibility loci. SIGNIFICANCE: The additional genes identified in this study, have an array of functions previously implicated in Alzheimer's disease, including aspects of energy metabolism, protein degradation and the immune system and add further weight to these pathways as potential therapeutic targets in Alzheimer's disease.

Indexed as

Alzheimer DiseaseCarrier ProteinsCase-Control StudiesGenome-Wide Association StudyHeat-Shock ProteinsHumansPolymorphism, Single NucleotideReceptors, Antigen, B-CellCarrier ProteinsHeat-Shock ProteinsReceptors, Antigen, B-CellTP53INP1 protein, human

Identifiers

PMID24922517
PMCPMC4055488
OpenAlexW2100721190

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