Evidence map›Paper›PMID 24922509›Full record

ArticlePloS one2014

Microbiota and metabolome associated with immunoglobulin A nephropathy (IgAN).

Maria De Angelis, Eustacchio Montemurno, Maria Piccolo, Lucia Vannini, Gabriella Lauriero, Valentina Maranzano, Giorgia Gozzi, Diana Serrazanetti, Giuseppe Dalfino, Marco Gobbetti and 1 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02302287 (Gut-kidney Axis), which is not on this map. Cited by 135 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
135citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02302287 phase4unknown statusnot on this mapstarted 2015, after this paper: background citation

Gut-kidney Axis: Renal Effects of Meditarranean Diet and Low-protein Diet With Ketoacids to Restore Physiological Intestinal Mibrobiota in Chronic Kidney Disease

TypeinterventionalSponsorAzienda Sanitaria ASL Avellino 2Ran2015 to 2017Enrolled60ConditionsChronic Renal InsufficiencyArmsKetoacids diet, Mediterranean diet, Free diet
3 · Its place in the literature

Who cites it

135 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Trial
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article

75 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Maria De AngelisDepartment of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari, Italy.
Eustacchio MontemurnoDepartment of Emergency and Organ Transplantation, Nephrology Unit - University of Bari Aldo Moro, Bari, Italy.
Maria PiccoloDepartment of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari, Italy.
Lucia VanniniDepartment of Agricultural and Food Sciences, University of Bologna, Bologna, Italy.
Gabriella LaurieroDepartment of Emergency and Organ Transplantation, Nephrology Unit - University of Bari Aldo Moro, Bari, Italy.
Valentina MaranzanoDepartment of Emergency and Organ Transplantation, Nephrology Unit - University of Bari Aldo Moro, Bari, Italy.
Giorgia GozziDepartment of Agricultural and Food Sciences, University of Bologna, Bologna, Italy.
Diana SerrazanettiInter-departmental Centre for Industrial Agri-Food Research, University of Cesena, Cesena, Italy.
Giuseppe DalfinoDepartment of Emergency and Organ Transplantation, Nephrology Unit - University of Bari Aldo Moro, Bari, Italy.
Marco GobbettiDepartment of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari, Italy.
Loreto GesualdoDepartment of Emergency and Organ Transplantation, Nephrology Unit - University of Bari Aldo Moro, Bari, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed at investigating the fecal microbiota, and the fecal and urinary metabolome of non progressor (NP) and progressor (P) patients with immunoglobulin A nephropathy (IgAN). Three groups of volunteers were included in the study: (i) sixteen IgAN NP patients; (ii) sixteen IgAN P patients; and (iii) sixteen healthy control (HC) subjects, without known diseases. Selective media were used to determine the main cultivable bacterial groups. Bacterial tag-encoded FLX-titanium amplicon pyrosequencing of the 16S rDNA and 16S rRNA was carried out to determine total and metabolically active bacteria, respectively. Biochrom 30 series amino acid analyzer and gas-chromatography mass spectrometry/solid-phase microextraction (GC-MS/SPME) analyses were mainly carried out for metabolomic analyses. As estimated by rarefaction, Chao and Shannon diversity index, the lowest microbial diversity was found in P patients. Firmicutes increased in the fecal samples of NP and, especially, P patients due to the higher percentages of some genera/species of Ruminococcaceae, Lachnospiraceae, Eubacteriaceae and Streptococcaeae. With a few exceptions, species of Clostridium, Enterococcus and Lactobacillus genera were found at the highest levels in HC. Bacteroidaceae, Porphyromonadaceae, Prevotellaceae and Rikenellaceae families differed among NP, P and HC subjects. Sutterellaceae and Enterobacteriaceae species were almost the highest in the fecal samples of NP and/or P patients. Compared to HC subjects, Bifidobacterium species decreased in the fecal samples of NP and P. As shown by multivariate statistical analyses, the levels of metabolites (free amino acids and organic volatile compounds) from fecal and urinary samples markedly differentiated NP and, especially, P patients.

Indexed as

MetabolomeMicrobiotaAdultCase-Control StudiesFemaleGlomerulonephritis, IGAHumansMaleMiddle Aged

Identifiers

PMID24922509
PMCPMC4055632

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.