ArticleAmerican journal of respiratory and critical care medicine2014
Adiposity, fractional exhaled nitric oxide, and asthma in U.S. children.
Article in American journal of respiratory and critical care medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 88 citations in OpenAlex.
- Adiposity measures and childhood asthma: one size does not fit all.Pediatric research · 2026Article
- Overweight, obesity, adiposity measures, and asthma endotypes in Puerto Rican youth.American journal of respiratory and critical care medicine · 2026Article
- Inflammatory Dysregulation, Asthma, and Obesity in Children: What is the Relationship?Journal of inflammation research · 2026Review
- Associations between body weight, asthma burden, and type 2 inflammation among under-resourced children.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2026Article
- Obesity as the predominant contributor to asthma burden: insights from GBD and NHANES analyses.BMC public health · 2025Article
- Prevalence and Potential Risk Factors for T2-Low Asthma Among School-Aged Children in the National Health and Nutrition Examination Survey, 2007-2012.The journal of allergy and clinical immunology. In practice · 2025Article
- Review
- Associations of urinary organophosphate esters metabolites with asthma and lung function in adolescents.Journal of exposure science & environmental epidemiology · 2024Article
- Effect of Obesity on Lung Function in the Pediatric and Adult Populations with Asthma: A Review.Journal of clinical medicine · 2023Review
- Mechanistic Links Between Obesity and Airway Pathobiology Inform Therapies for Obesity-Related Asthma.Paediatric drugs · 2023Review
- Association of fractional exhaled nitric oxide with asthma morbidity in urban minority children.The Journal of asthma : official journal of the Association for the Care of Asthma · 2023Article
- Obesity-related asthma in children and adolescents.The Lancet. Child & adolescent health · 2022Review
- Asthma interactions between obesity and other risk factors.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2022Review
- Association between obesity and lung function in South African adolescents of African Ancestry.BMC pediatrics · 2022Article
- A nationwide survey of the association between nonalcoholic fatty liver disease and the incidence of asthma in Korean adults.PloS one · 2022Article
- The impact of obesity on immune function in pediatric asthma.Current opinion in allergy and clinical immunology · 2021Review
- Contribution of systemic and airway immune responses to pediatric obesity-related asthma.Paediatric respiratory reviews · 2021Review
- Relationship of Nutritional Status and Spirometric Parameters in Children with Bronchial Asthma.Sovremennye tekhnologii v meditsine · 2021Article
- A Multi-Omics Approach Reveals New Signatures in Obese Allergic Asthmatic Children.Biomedicines · 2020Article
- Asthma and Obesity in Children.Biomedicines · 2020Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
rationaleWhether allergic airway inflammation mediates the association between overweight or obesity and childhood asthma is unknown.
objectivesTo examine adiposity, asthma, and fractional exhaled nitric oxide (FeNO) in U.S. children.
methodsCross-sectional study of indicators of adiposity or obesity, FeNO (a biomarker of eosinophilic airway inflammation), and asthma in 2,681 children aged 6-17 years in the 2007-2010 National Health and Nutrition Examination Survey. Adiposity measures included body mass index (BMI), percent body fat (PBF), and waist circumference (WC). MEASUREMENTS AND MAIN
resultsBMI, PBF, and WC were associated with asthma among children with low FeNO (odds ratio, 1.54-1.68; P < 0.01), but not among children with increased FeNO. Among children without asthma, BMI, PBF, and WC were associated with higher FEV1 and FVC, and lower FEV1/FVC. Among children with asthma and a high FeNO, all adiposity indicators were associated with decreased FEV1/FVC (β = -1.5% to -1.7% per z score) but not with FEV1 or FVC. Higher BMI or PBF was associated with worse asthma severity or control in children with asthma and increased FeNO, but not in children with asthma and low FeNO. Similar results were obtained in a secondary multivariate analysis of overweight or obesity (defined as BMI ≥85th percentile) and asthma or indicators of asthma severity or control, stratified by FeNO level.
conclusionsAdiposity indicators are associated with asthma in children with low FeNO. Among children with asthma, adiposity indicators are associated with worse asthma severity or control in those with high FeNO.
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