ArticleInorganic chemistry2014
Gd(DOTAlaP): exploring the boundaries of fast water exchange in gadolinium-based magnetic resonance imaging contrast agents.
Article in Inorganic chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed.
- AND-logic MRI contrast by water flux modulation.Chemical science · 2026Article
- Phosphonate-Based Aza-Macrocycle Ligands for Low-Temperature, Stable Chelation of Medicinally Relevant Rare Earth Radiometals and Radiofluorination.Journal of the American Chemical Society · 2024Article
- Lanthanide Complexes (GdChemistry, an Asian journal · 2022Article
- Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers.Chemical reviews · 2019Review
- Fe-HBED Analogs: A Promising Class of Iron-Chelate Contrast Agents for Magnetic Resonance Imaging.Contrast media & molecular imaging · 2019Article
- Chiral DOTA chelators as an improved platform for biomedical imaging and therapy applications.Nature communications · 2018Article
- Hydration number: crucial role in nuclear magnetic relaxivity of Gd(III) chelate-based nanoparticles.Scientific reports · 2017Article
- Phosphonic acid: preparation and applications.Beilstein journal of organic chemistry · 2017Review
- MR imaging probes: design and applications.Dalton transactions (Cambridge, England : 2003) · 2015Review
- Probing the structure-relaxivity relationship of bis-hydrated Gd(DOTAla) derivatives.Inorganic chemistry · 2015Article
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5 authors.
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Abstract
Here, we describe the synthesis of the single amino acid chelator DOTAlaP and four of its derivatives. The corresponding gadolinium(III) complexes were investigated for their kinetic inertness, relaxometric properties at a range of fields and temperatures, water exchange rate, and interaction with human serum albumin (HSA). Derivatives with one inner-sphere water (q = 1) were determined to have a mean water residency time between 8 and 6 ns in phoshate-buffered saline at 37 °C. The corresponding europium complexes were also formed and used to obtain information on the hydration number of the corresponding coordination complexes. Two complexes capable of binding HSA were also synthesized, of which one, Gd(5b), contains no inner-sphere water, while the other derivative, Gd(4b), is a mixture of ca. 15% q =1 and 85% q = 0. In the presence of HSA, the latter displayed a very short mean water residency time (τM(310) = 2.4 ns) and enhanced relaxivity at intermediate and high fields. The kinetic inertness of Gd(4b) with respect to complex dissociation was decreased compared to its DOTAla analogue but still 100-fold more inert than [Gd(BOPTA)(H2O)](2-). Magnetic resonance imaging in mice showed that Gd(4b) was able to provide 38% better vessel to muscle contrast compared to the clinically used HSA binding agent MS-325.
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