SynthesisJournal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer2014
Patient-centered outcomes among lung cancer screening recipients with computed tomography: a systematic review.
Synthesis in Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 4 syntheses or guidelines pooled it, 103 citations in OpenAlex.
- Impact of low-dose computed tomography (LDCT) screening on lung cancer-related mortality.The Cochrane database of systematic reviews · 2022Pooled it
- Pooled it
- Lung Cancer Screening, Version 3.2018, NCCN Clinical Practice Guidelines in Oncology.Journal of the National Comprehensive Cancer Network : JNCCN · 2018Guideline
- An official American Thoracic Society/American College of Chest Physicians policy statement: implementation of low-dose computed tomography lung cancer screening programs in clinical practice.American journal of respiratory and critical care medicine · 2015Guideline
- Validation of the psychosocial consequences of screening in lung cancer questionnaire in the international lung screen trial Australian cohort.Health and quality of life outcomes · 2024Trial
- Psychological impact of lung cancer screening using a novel antibody blood test followed by imaging: the ECLS randomized controlled trial.Journal of public health (Oxford, England) · 2023Trial
- Shared Medical Decision Making in Lung Cancer Screening: Experienced versus Descriptive Risk Formats.Medical decision making : an international journal of the Society for Medical Decision Making · 2016Trial
- Scoping Review of Patient-Centered Outcomes in Gastrointestinal Cancer Care.Psycho-oncology · 2026Article
- Psychological distress in patients with detected pulmonary nodules from lung cancer screening.Translational lung cancer research · 2026Article
- Patients' experiences of, and psychological responses to, surveillance for pulmonary nodules detected through lung cancer screening.BMJ open respiratory research · 2025Article
- Article
- Risk-based lung cancer screening performance in a universal healthcare setting.Nature medicine · 2024Article
- Patient-centred outcomes of imaging tests: recommendations for patients, clinicians and researchers.BMJ quality & safety · 2023Article
- European lung cancer screening: valuable trial evidence for optimal practice implementation.The British journal of radiology · 2022Article
- Should psychological distress be listed as a surgical indication for indeterminate pulmonary nodules: protocol for a prospective cohort study in real-world settings.Journal of thoracic disease · 2022Article
- Cost-effectiveness and health impact of lung cancer screening with low-dose computed tomography for never smokers in Japan and the United States: a modelling study.BMC pulmonary medicine · 2022Article
- Lung Cancer Screening: Review and 2021 Update.Current pulmonology reports · 2022Review
- The person behind the nodule: a narrative review of the psychological impact of lung cancer screening.Translational lung cancer research · 2021Review
- What is the balance of benefits and harms for lung cancer screening with low-dose computed tomography?Journal of the Royal Society of Medicine · 2021Article
- Consequences of screening in colorectal cancer (COS-CRC): development and dimensionality of a questionnaire.BMC psychology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
introductionLung cancer screening using low-dose computed tomography (LDCT) is now widely recommended for adults who are current or former heavy smokers. It is important to evaluate the impact of screening on patient-centered outcomes. Among current and former smokers eligible for lung cancer screening, we sought to determine the consequences of screening with LDCT, and subsequent results, on patient-centered outcomes such as quality of life, distress, and anxiety.
methodsWe searched the Cochrane Central Register of Controlled Trials and Cochrane Database of Systematic Reviews (through the fourth Quarter 2012), MEDLINE (2000 to May 31, 2013), reference lists of articles, and Scopus for relevant English-language studies and systematic reviews. To evaluate the effect of LDCT screening on patient-centered outcomes, we included only randomized controlled trials (RCTs) involving asymptomatic adults. To evaluate the association of particular results and/or recommendations from a screening LDCT with patient-centered outcomes, we included results from RCTs as well as from cohort studies.
resultsA total of 8215 abstracts were reviewed. Five publications from two European RCTs and one publication from a cohort study conducted in the United States met inclusion criteria. The process of LDCT lung cancer screening was associated with short-term psychologic discomfort in many people but did not affect distress, worry, or health-related quality of life. False-positive results were associated with short-term increases in distress that returned to levels that were similar to those among people with negative results. Negative results were associated with short-term decreases in distress.
conclusionsAs lung cancer screening is implemented in the general population, it will be important to evaluate its association with patient-centered outcomes. People considering lung cancer screening should be aware of the possibility of distress caused by false-positive results. Clinicians may want to consider tailoring communication strategies that can decrease the distress associated with these results.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.