Evidence map›Paper›PMID 24921924›Full record

ReviewPLoS neglected tropical diseases2014

The role of platelets in the pathogenesis of viral hemorrhagic fevers.

Juan C Zapata, Dermot Cox, Maria S Salvato

Abstract readReview
In one paragraph

Review in PLoS neglected tropical diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Ribavirin for treating Crimean Congo haemorrhagic fever.The Cochrane database of systematic reviews · 2018
    Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Lassa Fever Natural History and Clinical Management.Current topics in microbiology and immunology · 2023
    Article
  17. Article
  18. Review
  19. Coagulopathy of Dengue and COVID-19: Clinical Considerations.Tropical medicine and infectious disease · 2022
    Review
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Juan C ZapataInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
Dermot CoxMolecular and Cellular Therapeutics School of Pharmacy, Royal College of Surgeons in Ireland, Dublin, Ireland.
Maria S SalvatoInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.

Funding

Recombinant Yellow Fever 17D-Lassa VaccineR01AI068961 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI SALVATO, MARIA S. · 2007 to 2009
$1.4M
Protection of vaccine immunity by inhibiting Fas/FasL signalingRC2CA149001 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI SALVATO, MARIA S. · 2009 to 2010
$985k
NCI NIH HHS 5RC2CA149001NCI NIH HHS RC2 CA149001NIAID NIH HHS AI068961NIAID NIH HHS R01 AI068961
6 · The paper itself

Abstract

Viral hemorrhagic fevers (VHF) are acute zoonotic diseases that, early on, seem to cause platelet destruction or dysfunction. Here we present the four major ways viruses affect platelet development and function and new evidence of molecular factors that are preferentially induced by the more pathogenic members of the families Flaviviridae, Bunyaviridae, Arenaviridae, and Filoviridae. A systematic search was performed through the main medical electronic databases using as parameters all current findings concerning platelets in VHF. Additionally, the review contains information from conference proceedings.

Indexed as

Host-Pathogen InteractionsBlood PlateletsHemorrhagic Fevers, ViralHumansRNA Viruses

Identifiers

PMID24921924
PMCPMC4055450

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.