Trial reportBritish journal of cancer2014
Feasibility RCT of definitive chemoradiotherapy or chemotherapy and surgery for oesophageal squamous cell cancer.
Trial report in British journal of cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 4 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Pooled it
- Prognostic impact of tumor length in esophageal Cancer: a systematic review and Meta-analysis.BMC cancer · 2021Pooled it
- Non-surgical versus surgical treatment for oesophageal cancer.The Cochrane database of systematic reviews · 2016Pooled it
- A systematic review of training programmes for recruiters to randomised controlled trials.Trials · 2015Pooled it
- Patient-reported outcomes during and after definitive chemoradiotherapy for oesophageal cancer.British journal of cancer · 2015Trial
- Supporting recruitment into complex trials: An embedded qualitative process evaluation in the RADICAL trial of radiofrequency denervation for chronic low back pain.British journal of pain · 2026Article
- Article
- The development and acceptability of an educational and training intervention for recruiters to neonatal trials: the TRAIN project.BMC medical research methodology · 2023Article
- Advances in the curative management of oesophageal cancer.British journal of cancer · 2022Review
- Review
- Multidisciplinary treatment of esophageal cancer: The role of active surveillance after neoadjuvant chemoradiation.Annals of gastroenterological surgery · 2020Review
- Article
- The QuinteT Recruitment Intervention supported five randomized trials to recruit to target: a mixed-methods evaluation.Journal of clinical epidemiology · 2019Article
- Towards an Organ-Sparing Approach for Locally Advanced Esophageal Cancer.Digestive surgery · 2019Review
- Overcoming difficulties with equipoise to enable recruitment to a randomised controlled trial of partial ablation vs radical prostatectomy for unilateral localised prostate cancer.BJU international · 2018Article
- The prognostic impact of tumor length in esophageal cancer: Protocol for a systematic review and meta-analysis.Medicine · 2018Article
- Neoadjuvant chemoradiotherapy plus surgery versus active surveillance for oesophageal cancer: a stepped-wedge cluster randomised trial.BMC cancer · 2018Article
- Article
- Enabling recruitment success in bariatric surgical trials: pilot phase of the By-Band-Sleeve study.International journal of obesity (2005) · 2017Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe optimal treatment for localised oesophageal squamous cell carcinoma (SCC) is uncertain. We assessed the feasibility of an RCT comparing neoadjuvant treatment and surgery with definitive chemoradiotherapy.
methodsA feasibility RCT in three centres examined incident patients and reasons for ineligibility using multi-disciplinary team meeting records. Eligible patients were offered participation in the RCT with integrated qualitative research involving audio-recorded recruitment appointments and interviews with patients to inform recruitment training for staff.
resultsOf 375 patients with oesophageal SCC, 42 (11.2%) were eligible. Reasons for eligibility varied between centres, with significantly differing proportions of patients excluded because of total tumour length (P=0.002). Analyses of audio-recordings and patient interviews showed that recruiters had challenges articulating the trial design in simple terms, balancing treatment arms and explaining the need for randomisation. Before analyses of the qualitative data and recruiter training no patients were randomised. Following training in one centre 5 of 16 eligible patients were randomised.
conclusionsAn RCT of surgical vs non-surgical treatment for SCC of the oesophagus is not feasible in the UK alone because of the low number of incident eligible patients. A trial comparing diverse treatment approaches may be possible with investment to support the recruitment process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.