Evidence map›Paper›PMID 24921918›Full record

ArticleBritish journal of cancer2014

Possible pro-carcinogenic association of endotoxin on lung cancer among Shanghai women textile workers.

H Checkoway, J I Lundin, S Costello, R Ray, W Li, E A Eisen, G Astrakianakis, N Seixas, K Applebaum, D L Gao and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Textile industry and occupational cancer.Journal of occupational medicine and toxicology (London, England) · 2016
    Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 3 countries.

H CheckowayDepartment of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
J I LundinDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195, USA.
S CostelloDepartment of Environmental Health Sciences, University of California, Berkeley, CA 94720, USA.
R RayDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
W LiDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
E A EisenDepartment of Environmental Health Sciences, University of California, Berkeley, CA 94720, USA.
G AstrakianakisSchool of Population and Public Health, University of British Columbia, Vancouver, BC V6T1Z4, Canada.
N SeixasDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195, USA.
K ApplebaumDepartment of Environmental and Occupational Health, George Washington University, Washington, DC 20052, USA.
D L GaoZhong Shan Hospital Cancer Center, Shanghai 200030, China.
D B ThomasDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Fred Hutch Cancer Center · USUniversity of California, Berkeley · USCape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa · ZAGeorge Washington University · USSeattle University · USShanxi Provincial Cancer Hospital · CNUniversity of California, San Diego · USUniversity of Washington · US

Funding

CANCER RISKS AMONG TEXTILE WORKERS IN CHINAR01CA080180 · NCI · UNIVERSITY OF WASHINGTON · PI CHECKOWAY, HARVEY · 2000 to 2011
$4.3M
NCI NIH HHS R01 CA080180NCI NIH HHS R01CA80180
6 · The paper itself

Abstract

backgroundEndotoxin (lipopolysaccharide) is a widespread contaminant in many environmental settings. Since the 1970s, there has been generally consistent evidence indicating reduced risks for lung cancer associated with occupational endotoxin exposure.

methodsWe updated a case-cohort study nested within a cohort of 267,400 female textile workers in Shanghai, China. We compared exposure histories of 1456 incident lung cancers cases diagnosed during 1989-2006 with those of a reference subcohort of 3022 workers who were free of lung cancer at the end of follow-up. We applied Cox proportional hazards modelling to estimate exposure-response trends, adjusted for age and smoking, for cumulative exposures lagged by 0, 10, and 20 years, and separately for time windows of ⩽15 and >15 years since first exposure.

resultsWe observed no associations between cumulative exposure and lung cancer, irrespective of lag interval. In contrast, analyses by exposure time windows revealed modestly elevated, but not statistically significant relative risks (∼1.27) at the highest three exposure quintiles for exposures that occurred >15 years since first exposure.

conclusionsThe findings do not support a protective effect of endotoxin, but are suggestive of possible lung cancer promotion with increasing time since first exposure.

Indexed as

Occupational ExposureAgedAged, 80 and overAir PollutantsCarcinogenesisCase-Control StudiesCotton FiberDustFemaleHumansLipopolysaccharidesLung NeoplasmsMiddle AgedOccupational DiseasesProportional Hazards ModelsRisk FactorsAir PollutantsDustLipopolysaccharides

Identifiers

PMID24921918
PMCPMC4119981
OpenAlexW2079711247

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.