Evidence map›Paper›PMID 24921916›Full record

ArticleBritish journal of cancer2014

The prognostic impact of the neutrophil-to-lymphocyte ratio in patients with small-cell lung cancer.

M H Kang, S-I Go, H-N Song, A Lee, S-H Kim, J-H Kang, B-K Jeong, K M Kang, H Ling, G-W Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
120citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

120 citing papers in PubMed, 11 syntheses or guidelines pooled it.

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  4. Prognostic significance of pretreatment neutrophil-to-lymphocyte ratio in patients with laryngeal cancer: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021
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  17. Hematological Ratios inAnimals : an open access journal from MDPI · 2026
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60 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

M H KangDivision of Hematology-Oncology, Department of Internal Medicine, Gyeongsang National University Hospital Gyeongsang National University School of Medicine, Jinju, Republic of Korea.
S-I GoDivision of Hematology-Oncology, Department of Internal Medicine, Gyeongsang National University Hospital Gyeongsang National University School of Medicine, Jinju, Republic of Korea.
H-N SongDivision of Hematology-Oncology, Department of Internal Medicine, Gyeongsang National University Hospital Gyeongsang National University School of Medicine, Jinju, Republic of Korea.
A LeeDivision of Hematology-Oncology, Department of Internal Medicine, Gyeongsang National University Hospital Gyeongsang National University School of Medicine, Jinju, Republic of Korea.
S-H KimDivision of Hematology and Medical Oncology, Department of Internal Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of Korea.
J-H Kang1] Division of Hematology-Oncology, Department of Internal Medicine, Gyeongsang National University Hospital Gyeongsang National University School of Medicine, Jinju, Republic of Korea [2] Gyeongsang Institute of Health Sciences, Jinju, Republic of Korea.
B-K JeongDepartment of Radiation Oncology, Gyeongsang National University Hospital Gyeongsang National University School of Medicine, Jinju, Republic of Korea.
K M KangDepartment of Radiation Oncology, Gyeongsang National University Hospital Gyeongsang National University School of Medicine, Jinju, Republic of Korea.
H LingDepartment of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
G-W Lee1] Division of Hematology-Oncology, Department of Internal Medicine, Gyeongsang National University Hospital Gyeongsang National University School of Medicine, Jinju, Republic of Korea [2] Gyeongsang Institute of Health Sciences, Jinju, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are prognostic factors for various types of cancer. In this study, we assessed the association of NLR and PLR with the prognosis of small-cell lung cancer (SCLC) in patients who received the standard treatment.

methodsWe retrospectively reviewed patients who were diagnosed with SCLC and treated with platinum-based chemotherapy between July 2006 and October 2013 in Gyeongsang National University Hospital Regional Cancer Center and Changwon Samsung Hospital.

resultsIn total, 187 patients were evaluated. Compared with low NLR (<4), high NLR (⩾4) at diagnosis was associated with poor performance status, advanced stage, and lower response rate. Median overall survival (OS) and progression-free survival (PFS) were worse in the high-NLR group (high vs low, 11.17 vs 9.20 months, P=0.019 and 6.90 vs 5.49 months, P=0.005, respectively). In contrast, PLR at diagnosis was not associated with OS or PFS (P=0.467 and P=0.205, respectively). In multivariate analysis, stage, lactate dehydrogenase, and NLR at diagnosis were independent prognostic factors for OS and PFS.

conclusionsNLR is easily measurable and reflects the SCLC prognosis. A future prospective study is warranted to confirm our results.

Indexed as

AdultAgedAged, 80 and overDisease-Free SurvivalFemaleHumansKaplan-Meier EstimateLung NeoplasmsLymphocyte CountLymphocytesMaleMiddle AgedMultivariate AnalysisNeutrophilsPlatelet CountPrognosis

Identifiers

PMID24921916
PMCPMC4119986

What OpenQuestion holds

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LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.