Evidence map›Paper›PMID 24921413›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2014

Heart rate variability in encephalopathic newborns during and after therapeutic hypothermia.

A N Massaro, R B Govindan, T Al-Shargabi, N N Andescavage, M Metzler, T Chang, P Glass, A J du Plessis

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
7.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Observational
  5. Article
  6. Article
  7. Observational
  8. Article
  9. Prediction of outcome of hypoxic-ischemic encephalopathy in newborns undergoing therapeutic hypothermia using heart rate variability.Journal of perinatology : official journal of the California Perinatal Association · 2024
    Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Observational
  16. Article
  17. Article
  18. Cerebral cortical autonomic connectivity in low-risk term newborns.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

A N Massaro1] Department of Neonatology, Children's National Medical Center, Washington, DC, USA [2] Department of Fetal and Transitional Medicine, Children's National Medical Center, Washington, DC, USA [3] Department of Pediatrics, The George Washington University School of Medicine, Washington, DC, USA.
R B Govindan1] Department of Fetal and Transitional Medicine, Children's National Medical Center, Washington, DC, USA [2] Department of Pediatrics, The George Washington University School of Medicine, Washington, DC, USA.
T Al-Shargabi1] Department of Fetal and Transitional Medicine, Children's National Medical Center, Washington, DC, USA [2] Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, USA.
N N Andescavage1] Department of Neonatology, Children's National Medical Center, Washington, DC, USA [2] Department of Fetal and Transitional Medicine, Children's National Medical Center, Washington, DC, USA [3] Department of Pediatrics, The George Washington University School of Medicine, Washington, DC, USA.
M MetzlerDepartment of Fetal and Transitional Medicine, Children's National Medical Center, Washington, DC, USA.
T Chang1] Department of Pediatrics, The George Washington University School of Medicine, Washington, DC, USA [2] Department of Neurology, Children's National Medical Center, Washington, DC, USA.
P Glass1] Department of Pediatrics, The George Washington University School of Medicine, Washington, DC, USA [2] Department of Psychiatry and Behavioral Sciences, Children's National Medical Center, Washington, DC, USA.
A J du Plessis1] Department of Fetal and Transitional Medicine, Children's National Medical Center, Washington, DC, USA [2] Department of Pediatrics, The George Washington University School of Medicine, Washington, DC, USA.
George Washington University · USChildren's National · US

Funding

ZAP-70 EXPRESSION, CD38 EXPRESSION AND PROGNOSIS IN CHRONIC LYMPHOCYTIC LEUKEMIAM01RR020359 · NCRR · CHILDREN'S RESEARCH INSTITUTE · PI HINDS, PAMELA S · 2005 to 2010
$13.8M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR031988 · NCRR · CHILDREN'S RESEARCH INSTITUTE · PI JOSEPH, JILL G · 2010 to 2011
$8.2M
Clinical and Translational Science Institute at Children's NationalKL2RR031987 · NCRR · CHILDREN'S RESEARCH INSTITUTE · PI GUAY-WOODFORD, LISA MARIE · 2010 to 2011
$425k
NCRR NIH HHS KL2 RR031987NCRR NIH HHS M01 RR020359NCRR NIH HHS UL1 RR031988NCRR NIH HHS UL1RR031988
6 · The paper itself

Abstract

objectiveTo evaluate whether heart rate variability (HRV) measures are predictive of neurological outcome in babies with hypoxic ischemic encephalopathy (HIE). STUDY

designThis case-control investigation included 20 term encephalopathic newborns treated with systemic hypothermia in a regional neonatal intensive care unit. Electrocardiographic data were collected continuously during hypothermia. Spectral analysis of beat-to-beat heart rate interval was used to quantify HRV. HRV measures were compared between infants with adverse outcome (death or neurodevelopmental impairment at 15 months, n = 10) and those with favorable outcome (survivors without impairment, n = 10).

resultHRV differentiated infants by outcome during hypothermia through post-rewarming, with the best distinction between groups at 24 h and after 80 h of life.

conclusionHRV during hypothermia treatment distinguished HIE babies who subsequently died or had neurodevelopmental impairment from intact survivors. This physiological biomarker may identify infants in need of adjuvant neuroprotective interventions. These findings warrant further investigation in a larger population of infants with HIE.

Indexed as

Hypothermia, InducedAdultFemaleHeart RateHumansHypoxia-Ischemia, BrainInfant, NewbornMaleROC CurveSurvival Analysis

Identifiers

PMID24921413
PMCPMC4216618
OpenAlexW1981682832

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.