ArticleJournal of perinatology : official journal of the California Perinatal Association2014
The effect of red blood cell transfusion on intermittent hypoxemia in ELBW infants.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Comparative efficacy and safety of restrictive versus liberal transfusion thresholds in anemic preterm infants: a meta-analysis of 12 randomized controlled trials.Annals of hematology · 2023Pooled it
- Restrictive versus liberal transfusion thresholds in very low birth weight infants: A systematic review with meta-analysis.PloS one · 2021Pooled it
- Effects of liberal versus restrictive transfusion strategies on intermittent hypoxaemia in extremely low birthweight infants: secondary analyses of the ETTNO randomised controlled trial.Archives of disease in childhood. Fetal and neonatal edition · 2025Trial
- Higher or Lower Hemoglobin Transfusion Thresholds for Preterm Infants.The New England journal of medicine · 2020Trial
- Short-Term Physiological Effects of Red Blood Cell Transfusion in Very Low Birth Weight Infants: A Retrospective Cohort Study.Children (Basel, Switzerland) · 2026Article
- Immature control of breathing and apnea of prematurity: the known and unknown.Journal of perinatology : official journal of the California Perinatal Association · 2021Review
- Response to first dose of inhaled albuterol in mechanically ventilated preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- Extubation Readiness in Preterm Infants: Evaluating the Role of Monitoring Intermittent Hypoxemia.Children (Basel, Switzerland) · 2021Article
- Simultaneous measurements of tissue blood flow and oxygenation using a wearable fiber-free optical sensor.Journal of biomedical optics · 2021Article
- Intermittent hypoxia and bronchial hyperreactivity.Seminars in fetal & neonatal medicine · 2020Review
- Clinical quantification of SpOPediatric research · 2020Observational
- Intermittent Hypoxemia in Preterm Infants.Clinics in perinatology · 2019Review
- Intermittent hypoxemia and oxidative stress in preterm infants.Respiratory physiology & neurobiology · 2019Review
- Blood transfusions in preterm infants: changes on perfusion index and intermittent hypoxemia.Transfusion · 2018Article
- Red Cell Transfusion Practices in Neonatal Intensive Care Unit: An Experience from Tertiary Care Centre.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2018Article
- Prenatal Opioid Exposure and Intermittent Hypoxemia in Preterm Infants: A Retrospective Assessment.Frontiers in pediatrics · 2017Article
- Cardiorespiratory events in preterm infants: interventions and consequences.Journal of perinatology : official journal of the California Perinatal Association · 2016Review
- Apnea, intermittent hypoxia and blood transfusions: it works, but now what?Journal of perinatology : official journal of the California Perinatal Association · 2014Article
- Transfusion support in preterm neonates <1500 g and/or <32 weeks in a tertiary care center: A descriptive study.Asian journal of transfusion scienceArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo test the hypothesis that the effect of red blood cell (RBC) transfusion on intermittent hypoxemia (IH) in extremely low birth weight (ELBW) infants is dependent on postnatal age. STUDY
designOxygen saturation of 130 ELBW infants, who required transfusion, was monitored continuously for the first 8 weeks of life. We compared the characteristics of IH (SpO2⩽80% for ⩾4 s and ⩽3 min), 24 h before and both 24 h and 24 to 48 h after each RBC transfusion at three distinct time periods: Epoch 1, 1 to 7 days; Epoch 2, 8 to 28 days; and Epoch 3, >28 days.
resultIn Epoch 1, the frequency and severity of IH events were not significantly different before and after transfusion. In both Epochs 2 and 3 there was a decrease in IH frequency and severity 24 h after RBC transfusion that persisted for 48 h. In addition, there was a decrease in the overall time spent with SpO2 ⩽80% which persisted for 24 h after transfusion in Epochs 1 and 3, and for 48 h in Epoch 3.
conclusionThe benefit of RBC transfusion on IH is age dependent as improvement in the frequency and severity of IH after transfusion only occurs beyond the first week of life. These observations will aid clinician's decision making by clarifying the benefit of RBC transfusions on patterns of oxygenation in preterm infants.
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Registered trials
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