Evidence map›Paper›PMID 24921027›Full record

ArticleInternational journal of stem cells2014

In Vivo Roles of a Patient-Derived Induced Pluripotent Stem Cell Line (HD72-iPSC) in the YAC128 Model of Huntington's Disease.

Iksoo Jeon, Chunggab Choi, Nayeon Lee, Wooseok Im, Manho Kim, Seung-Hun Oh, In-Hyun Park, Hyun Sook Kim, Jihwan Song

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Article in International journal of stem cells, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Review
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  11. Stem cell therapy in autism: recent insights.Stem cells and cloning : advances and applications · 2018
    Review
  12. Article
  13. Review
  14. Modeling simple repeat expansion diseases with iPSC technology.Cellular and molecular life sciences : CMLS · 2016
    Review
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  20. Neurodegenerative diseases in a dish: the promise of iPSC technology in disease modeling and therapeutic discovery.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Iksoo JeonCHA Stem Cell Institute, CHA University.
Chunggab ChoiCHA Stem Cell Institute, CHA University.
Nayeon LeeCHA Stem Cell Institute, CHA University.
Wooseok ImDepartment of Neurology, Biomedical Research Institute, Seoul National University Hospital, Seoul.
Manho KimDepartment of Neurology, Biomedical Research Institute, Seoul National University Hospital, Seoul.
Seung-Hun OhDepartment of Neurology, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
In-Hyun ParkDepartment of Genetics, Yale University School of Medicine, New Haven, USA.
Hyun Sook KimDepartment of Neurology, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
Jihwan SongCHA Stem Cell Institute, CHA University.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Induced pluripotent stem cells (iPSCs) generated from somatic cells of patients can provide immense opportunities to model human diseases, which may lead to develop novel therapeutics. Huntington's disease (HD) is a devastating neurodegenerative genetic disease, with no available therapeutic options at the moment. We recently reported the characteristics of a HD patient-derived iPSC carrying 72 CAG repeats (HD72-iPSC). In this study, we investigated the in vivo roles of HD72-iPSC in the YAC128 transgenic mice, a commonly used HD mouse model carrying 128 CAG repeats. To do this, we transplanted HD72-iPSC-derived neural precursors into the striatum of YAC128 mice bilaterally and observed a significant behavioral improvement in the grafted mice. Interestingly, the transplanted HD72-iPSC-derived neural precursors formed GABAeric neurons efficiently, but no EM48-positive protein aggregates were detected at 12 weeks after transplantation. Taken together, these results indicate no HD pathology was developed from the grafted cells, or no transmission of HD pathology from the host to the graft occurred at 12 weeks post-transplantation.

Indexed as

Aggregate formationGABAergic neuronsHuntington’s disease (HD)Induced pluripotent stem cells (iPSCs)YAC128 transgenic mice

Identifiers

PMID24921027
PMCPMC4049731

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.