Evidence map›Paper›PMID 24920909›Full record

ArticleInternational journal of nanomedicine2014

Mussel-inspired human gelatin nanocoating for creating biologically adhesive surfaces.

Xi Yang, Liping Zhu, Seiichi Tada, Di Zhou, Takashi Kitajima, Takashi Isoshima, Yasuhiro Yoshida, Mariko Nakamura, Weiqun Yan, Yoshihiro Ito

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Mussel-inspired biomaterials: From chemistry to clinic.Bioengineering & translational medicine · 2022
    Review
  4. Review
  5. Article
  6. Polydopamine Surface Chemistry: A Decade of Discovery.ACS applied materials & interfaces · 2018
    Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Xi YangNano Medical Engineering Laboratory, RIKEN, Saitama, Japan ; School of Pharmaceutical Sciences, Jilin University, Jilin, People's Republic of China.
Liping ZhuNano Medical Engineering Laboratory, RIKEN, Saitama, Japan.
Seiichi TadaNano Medical Engineering Laboratory, RIKEN, Saitama, Japan.
Di ZhouEmergent Bioengineering Materials Research Team, RIKEN Center for Emergent Matter Science, Saitama.
Takashi KitajimaNano Medical Engineering Laboratory, RIKEN, Saitama, Japan.
Takashi IsoshimaNano Medical Engineering Laboratory, RIKEN, Saitama, Japan.
Yasuhiro YoshidaNano Medical Engineering Laboratory, RIKEN, Saitama, Japan ; Department of Biomaterials and Bioengineering, Graduate School of Dental Medicine, Hokkaido University, Hokkaido.
Mariko NakamuraNano Medical Engineering Laboratory, RIKEN, Saitama, Japan ; Dental Hygiene Program, Kibi International College, Okayama, Japan.
Weiqun YanSchool of Pharmaceutical Sciences, Jilin University, Jilin, People's Republic of China.
Yoshihiro ItoNano Medical Engineering Laboratory, RIKEN, Saitama, Japan ; Emergent Bioengineering Materials Research Team, RIKEN Center for Emergent Matter Science, Saitama.
RIKEN · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recombinant human gelatin was conjugated with dopamine using carbodiimide as a surface modifier. This dopamine-coupled human gelatin (D-rhG) was characterized by (1)H-nuclear magnetic resonance, mass spectroscopy, and circular dichroism. D-rhG-coated surface properties were analyzed by physicochemical methods. Additionally, cell attachment and growth on the modified surfaces was assessed using human umbilical endothelial cells. Binding of gelatin onto titanium was significantly enhanced by dopamine conjugation. The thickness of the D-rhG coating depended on the treatment pH; thicker layers were formed at higher pH values, with a maximum thickness of 30 nm. D-rhG enhanced the binding of collagen-binding vascular endothelial growth factor and cell adhesion as compared with gelatin alone, even at the same surface concentration. The D-rhG surface modifier enhanced substrate binding by creating an adhesive nanointerface that increased specific protein binding and cell attachment.

Indexed as

AdhesivesAnimalsBiomimetic MaterialsBivalviaCell AdhesionCells, CulturedDopamineEndothelial CellsGelatinHumansMaterials TestingAdhesivesDopamineGelatincell adhesioncell culturedopaminenatural catecholsrecombinant human gelatintitanium

Identifiers

PMID24920909
PMCPMC4045085
OpenAlexW2092631450

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.