ArticleJournal of clinical microbiology2014
Hypertrophic adenoid is a major infection site of human bocavirus 1.
Article in Journal of clinical microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Atopic Features and Inflammatory Markers Across Cassano-Graded Adenoid Hypertrophy.Children (Basel, Switzerland) · 2026Article
- Twenty years of human bocavirus research: from an unculturable virus of unclear pathogenicity to a culturable human pathogen and gene therapy vector candidate.Clinical microbiology reviews · 2025Review
- Evaluation of Lytic and Persistent Human Adenovirus Infections in Tonsil Tissue of Children With Tonsillar Hypertrophy: A Matched Case-Control Study.Laryngoscope investigative otolaryngology · 2025Article
- MA104 cell line is permissive for human bocavirus 1 infection.Journal of virology · 2025Article
- Adenoid Hypertrophy and Orthodontic Complications: An Assessment of Parental Knowledge in Saudi Arabia.Cureus · 2023Article
- Adenoid lymphocyte heterogeneity in pediatric adenoid hypertrophy and obstructive sleep apnea.Frontiers in immunology · 2023Article
- The role of human bocavirus as an agent of community-acquired pneumonia in children under 5 years of age in Fortaleza, Ceará (Northeast Brazil).Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Article
- Herpesvirus infections in adenoids in patients with chronic adenotonsillar disease.Journal of medical virology · 2022Article
- Expression and clinical significance of IL-33 and its receptor ST2 in children with obstructive sleep apnea syndrome.Translational pediatrics · 2022Article
- Persistent human bocavirus 1 infection and tonsillar immune responses.Clinical and translational allergy · 2021Article
- Article
- Molecular screening of the human parvoviruses B19 and bocavirus 1 in the study of congenital diseases as applied to symptomatic pregnant women and children.Access microbiology · 2019Article
- Prevalence of Human Bocavirus in Africa and Other Developing Countries between 2005 and 2016: A Potential Emerging Viral Pathogen for Diarrhea.Journal of tropical medicine · 2018Review
- Adenoidectomy in Children: What Is the Evidence and What Is its Role?Current otorhinolaryngology reports · 2018Review
- Association of the Human Bocavirus With Tonsil Squamous Cell Carcinomas.Frontiers in microbiology · 2018Article
- Respiratory DNA viruses are undetectable in nasopharyngeal secretions from adenotonsillectomized children.PloS one · 2017Article
- The ubiquity of asymptomatic respiratory viral infections in the tonsils and adenoids of children and their impact on airway obstruction.International journal of pediatric otorhinolaryngology · 2016Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human bocavirus 1 (HBoV1) is associated with respiratory infections worldwide, mainly in children. Similar to other parvoviruses, it is believed that HBoV1 can persist for long periods of time in humans, probably through maintaining concatemers of the virus single-stranded DNA genome in the nuclei of infected cells. Recently, HBoV-1 was detected in high rates in adenoid and palatine tonsils samples from patients with chronic adenotonsillar diseases, but nothing is known about the virus replication levels in those tissues. A 3-year prospective hospital-based study was conducted to detect and quantify HBoV1 DNA and mRNAs in samples of the adenoids (AD), palatine tonsils (PT), nasopharyngeal secretions (NPS), and peripheral blood (PB) from patients undergoing tonsillectomy for tonsillar hypertrophy or recurrent tonsillitis. HBoV1 was detected in 25.3% of the AD samples, while the rates of detection in the PT, NPS, and PB samples were 7.2%, 10.5%, and 1.7%, respectively. The viral loads were higher in AD samples, and 27.3% of the patients with HBoV had mRNA detectable in this tissue. High viral loads and detectable mRNA in the AD were associated with HBoV1 detection in the other sample sites. The adenoids are an important site of HBoV1 replication and persistence in children with tonsillar hypertrophy. The adenoids contain high HBoV1 loads and are frequently positive for HBoV mRNA, and this is associated with the detection of HBoV1 in secretions.
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