ArticleIntegrative and comparative biology2014
The Drosophila egg chamber-a new spin on how tissues elongate.
Article in Integrative and comparative biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 60 citations in OpenAlex.
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- Shaping Drosophila eggs: unveiling the roles of Arpc1 and cpb in morphogenesis.Functional & integrative genomics · 2024Article
- Conserved physical mechanisms of cell and tissue elongation.Development (Cambridge, England) · 2024Review
- Bellymount-Pulsed Tracking: A Novel Approach for Real-Time In vivo Imaging ofbioRxiv : the preprint server for biology · 2024Article
- Understanding bovine embryo elongation: a transcriptomic study of trophoblastic vesicles.Frontiers in physiology · 2024Article
- Sculpting with stiffness: rigidity as a regulator of morphogenesis.Biochemical Society transactions · 2023Review
- Breakthrough treatments for accelerated wound healing.Science advances · 2023Review
- Quantitative videomicroscopy reveals latent control of cell-pair rotations in vivo.Development (Cambridge, England) · 2023Article
- Who's really in charge: Diverse follower cell behaviors in collective cell migration.Current opinion in cell biology · 2023Review
- Optimized Fixation and Phalloidin Staining of Basally Localized F-Actin Networks in Collectively Migrating Follicle Cells.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Advances toward transformative therapies for tendon diseases.Science translational medicine · 2022Review
- Cross-tissue and generation predictability of relative Wolbachia densities in the mosquito Aedes aegypti.Parasites & vectors · 2022Article
- Tissue architecture: Two kinesins collaborate in building basement membrane.Current biology : CB · 2022Article
- An evolutionary and physiological perspective on cell-substrate adhesion machinery for cell migration.Frontiers in cell and developmental biology · 2022Review
- Juvenile hormone signaling promotes ovulation and maintains egg shape by inducing expression of extracellular matrix genes.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- To form and function: on the role of basement membrane mechanics in tissue development, homeostasis and disease.Open biology · 2021Review
- A single-cell atlas of adult Drosophila ovary identifies transcriptional programs and somatic cell lineage regulating oogenesis.PLoS biology · 2020Article
- Electrochemical gradients are involved in regulating cytoskeletal patterns during epithelial morphogenesis in the Drosophila ovary.BMC developmental biology · 2019Article
- Biomaterials to Mimic and Heal Connective Tissues.Advanced materials (Deerfield Beach, Fla.) · 2019Review
- Unicellular ancestry and mechanisms of diversification of Goodpasture antigen-binding protein.The Journal of biological chemistry · 2019 · on this mapArticle
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1 author at 1 institution in 1 country.
Funding
Abstract
During development, tissues undergo complex cellular rearrangements and changes in shape that produce a diversity of body plans and the functional organs therein. The Drosophila egg chamber has emerged as an exciting and highly tractable model in which to investigate novel mechanisms driving the elongation of tissues. Egg chambers are multicellular assemblies within flies' ovaries that will each give rise to a single egg. Although initially spherical, these simple organ-like structures lengthen as they grow. This transformation depends on an unusual form of planar polarity in the egg chamber's outer epithelial layer, in which arrays of linear actin bundles and fibril-like structures in the basement membrane both align perpendicular to the axis of elongation. The resulting circumferential arrangement of structural molecules is then thought to act as a "molecular corset" that directionally biases growth of the egg chamber. I will explore four fundamental questions about this system: (1) How is the circumferential pattern generated in the follicular epithelium? (2) What is the physical nature of the corset? (3) How does a corset-type mechanism lead to the cellular rearrangements necessary for the elongation of tissues? and (4) To what extent are the cellular mechanisms controlling egg chamber elongation conserved in other systems? For each topic, I will present insights gleaned from the recent literature and highlight fertile areas for future investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.