ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2014
Elevated maternal cortisol leads to relative maternal hyperglycemia and increased stillbirth in ovine pregnancy.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 54 citations in OpenAlex.
- Developmental programming: gestational exposure to excess testosterone disrupts maternal steroid homeostasis and perturbs the steroid-lipid relationship in sheep.Molecular and cellular endocrinology · 2026Article
- Biochemical analysis of catecholamine and cortisol for the evaluation of the fetal distress in third trimester stillbirths.International journal of legal medicine · 2024Article
- Preconception Stress and Pregnancy Serum Glucose Levels Among Women Attending a Fertility Center.Journal of the Endocrine Society · 2023Article
- Maternal hair cortisol concentrations and its association with increased insulin resistance in midpregnancy.Annals of epidemiology · 2023Article
- The impact of hyperglycemia upon BeWo trophoblast cell metabolic function: A multi-OMICS and functional metabolic analysis.PloS one · 2023Article
- Chronic maternal hypercortisolemia models stress-induced adverse birth outcome and altered cardiac function in newborn lambs.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Metabolic Consequences of Glucocorticoid Exposure before Birth.Nutrients · 2022Review
- DNA methylation and expression profiles of placenta and umbilical cord blood reveal the characteristics of gestational diabetes mellitus patients and offspring.Clinical epigenetics · 2022Article
- Sodium dichloroacetate stimulates cardiac mitochondrial metabolism and improves cardiac conduction in the ovine fetus during labor.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Vitamin B6 deficiency disrupts serotonin signaling in pancreatic islets and induces gestational diabetes in mice.Communications biology · 2021Article
- Maternal hypercortisolemia alters placental metabolism: a multiomics view.American journal of physiology. Endocrinology and metabolism · 2020Article
- Occupational exposure to whole-body vibrations and pregnancy complications: a nationwide cohort study in Sweden.Occupational and environmental medicine · 2020Article
- Pharmacokinetic and Biochemical Profiling of Sodium Dichloroacetate in Pregnant Ewes and Fetuses.Drug metabolism and disposition: the biological fate of chemicals · 2020Article
- Fetal ovine skeletal and cardiac muscle transcriptomics are differentially altered by increased maternal cortisol during gestation.Physiological genomics · 2020Article
- Observational
- Transcriptomic evidence that cortisol alters perinatal epicardial adipose tissue maturation.American journal of physiology. Endocrinology and metabolism · 2019Article
- Antenatal dexamethasone treatment transiently alters diastolic function in the mouse fetal heart.The Journal of endocrinology · 2019Article
- Mechanisms of in utero cortisol effects on the newborn heart revealed by transcriptomic modeling.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Chronic maternal cortisol excess during late gestation leads to metabolic alterations in the newborn heart.American journal of physiology. Endocrinology and metabolism · 2019Article
- A Transcriptomic Model of Postnatal Cardiac Effects of Prenatal Maternal Cortisol Excess in Sheep.Frontiers in physiology · 2019Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
In normal pregnancy, cortisol increases; however, further pathological increases in cortisol are associated with maternal and fetal morbidities. These experiments were designed to test the hypothesis that increased maternal cortisol would increase maternal glucose concentrations, suppress fetal growth, and impair neonatal glucose homeostasis. Ewes were infused with cortisol (1 mg·kg(-1)·day(-1)) from day 115 of gestation to term; maternal glucose, insulin, ovine placental lactogen, estrone, progesterone, nonesterified free fatty acids (NEFA), β-hydroxybutyrate (BHB), and electrolytes were measured. Infusion of cortisol increased maternal glucose concentration and slowed the glucose disappearance after injection of glucose; maternal infusion of cortisol also increased the incidence of fetal death at or near parturition. The design of the study was altered to terminate the study prior to delivery, and post hoc analysis of the data was performed to test the hypothesis that maternal metabolic factors predict the fetal outcome. In cortisol-infused ewes that had stillborn lambs, plasma insulin was increased relative to control ewes or cortisol-infused ewes with live lambs. Maternal cortisol infusion did not alter maternal food intake or plasma NEFA, BHB, estrone, progesterone or placental lactogen concentrations, and it did not alter fetal body weight, ponderal index, or fetal organ weights. Our study suggests that the adverse effect of elevated maternal cortisol on pregnancy outcome may be related to the effects of cortisol on maternal glucose homeostasis, and that chronic maternal stress or adrenal hypersecretion of cortisol may create fetal pathophysiology paralleling some aspects of maternal gestational diabetes.
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