ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
The basal thermal sensitivity of the TRPV1 ion channel is determined by PKCβII.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- RAGE mediates LPS-induced inflammatory pain in human skin - a double-blind, randomised, placebo-controlled full crossover study.Nature communications · 2026Trial
- An update on regulation of the polymodal TRPV4 channel by protein phosphorylation.Channels (Austin, Tex.) · 2026Review
- Piezo1 activation in endothelial cells aggravates microvascular ischemia-reperfusion injury in limbs by enhancing ferroptosis.Experimental & molecular medicine · 2026Article
- Thermosensory TRPV Heterotetramers Drive Seasonal Polyphenism: Molecular Basis of CcIav/CcNan-PKCα-AKH/AKHR Signaling in Pear Psyllid Morph Transition.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- CCK-sensitive C fibers activate NTS leptin receptor-expressing neurons via NMDA receptors.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- Loss of POMC-mediated antinociception contributes to painful diabetic neuropathy.Nature communications · 2021Article
- The Mysteries of Capsaicin-Sensitive Afferents.Frontiers in physiology · 2020Review
- Phosphorylation of TRPV1 S801 Contributes to Modality-Specific Hyperalgesia in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- CaInternational journal of molecular sciences · 2018Review
- RAGE-dependent potentiation of TRPV1 currents in sensory neurons exposed to high glucose.PloS one · 2018Article
- PKCβII-induced upregulation of PGP9.5 and VEGF in postoperative persistent pain in rats.Journal of pain research · 2018Article
- Paclitaxel inhibits the activity and membrane localization of PKCα and PKCβI/II to elicit a decrease in stimulated calcitonin gene-related peptide release from cultured sensory neurons.Molecular and cellular neurosciences · 2017Article
- The Phosphorylation State of theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Calmodulin is responsible for CaScientific reports · 2017Article
- Full-Spectral Multiplexing of Bioluminescence Resonance Energy Transfer in Three TRPV Channels.Biophysical journal · 2017Article
- Evolutionary tuning of TRPA1 and TRPV1 thermal and chemical sensitivity in vertebrates.Temperature (Austin, Tex.) · 2017Review
- ThermoTRPs and Pain.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2016Review
- Article
- Targeting TRP ion channels for itch relief.Naunyn-Schmiedeberg's archives of pharmacology · 2015Review
- Molecular sensors and modulators of thermoreception.Channels (Austin, Tex.) · 2015Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Peripheral nociceptors are excited by the activation of membrane receptors and ion channels. The heat-sensitive TRPV1 ion channel responds to various noxious chemical and thermal stimuli, causing pain and itch. Here, we show that TRPV1 is coexpressed with PKCβII in a subset of mouse sensory neurons and that, in these neurons, TRPV1 binds directly to PKCβII, leading to the activation and translocation of PKCβII. Activated PKCβII, in turn, significantly increases the responsiveness of TRPV1 by phosphorylating Thr705. The heat sensitivity of TRPV1 is almost eliminated by either knocking down PKCβII or mutating Thr705; however, neither of these manipulations affects the potentiation of TRPV1 caused by the activation of PKCε. PKCβII thus acts as an auxiliary subunit of TRPV1 by forming a population-dependent TRPV1 ion channel complex controlling the sensitivity of TRPV1 and setting the threshold for pain and itch.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.