Evidence map›Paper›PMID 24920437›Full record

SynthesisHuman reproduction update

Central changes associated with chronic pelvic pain and endometriosis.

Jennifer Brawn, Matteo Morotti, Krina T Zondervan, Christian M Becker, Katy Vincent

4 registry-linked trialsOpen access · bronzeAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Human reproduction update. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 91 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed, 4 pooled it
27.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02867774 nacompletednot on this map

Impact of Physical Activity for Chronic Pelvic Pain

TypeinterventionalSponsorUniversity of MichiganRan2016 to 2017Enrolled22ConditionsPelvic PainArmsPhysical Activity
NCT04527003 phase3terminatednot on this map

A Randomized Controlled Pilot Study of the Use of Cannabidiol in the Management of Endometriosis Pain

TypeinterventionalSponsorMilton S. Hershey Medical CenterRan2020 to 2024Enrolled12ConditionsEndometriosis, CBD, Pelvic PainArmsCannabidiol (CBD) Extract, Norethindrone Acetate, Placebo
NCT05771753 naunknown statusnot on this map

Comparison of Core Stabilization and Dynamic Stretching Exercises on Symptoms Severity and Quality of Life in Primary Dysmenorrhea

TypeinterventionalSponsorRiphah International UniversityRan2022 to 2023Enrolled32ConditionsPrimary DysmenorrheaArmsStretching Exercises, Dynamic core stabilizing exercises
NCT05968937 phase2completednot on this map

Baclofen in Chronic Pelvic Pain, a Randomized, Double-Blind, Placebo Controlled Trial

TypeinterventionalSponsorUniversity of LouisvilleRan2024 to 2026Enrolled39ConditionsChronic Pelvic Pain SyndromeArms20 mg baclofen vaginal suppository daily per vagina, Placebo
3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 4 syntheses or guidelines pooled it, 263 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Surgical interventions for the management of chronic pelvic pain in women.The Cochrane database of systematic reviews · 2021
    Pooled it
  4. Pooled it
  5. Psychological interventions improve quality of life despite persistent pain in endometriosis: results of a 3-armed randomized controlled trial.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023
    Trial
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Review
  12. Review
  13. Building Disease Models for Endometriosis: iPSCs as Game-Changers.International journal of molecular sciences · 2026
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Jennifer BrawnNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK jennifer.brawn@ndcn.ox.ac.uk.
Matteo MorottiNuffield Department of Obstetrics and Gynaecology, University of Oxford, Women's Centre, John Radcliffe Hospital, Oxford, UK Department of Obstetrics and Gynaecology, University of Genoa, Genoa 16100, Italy.
Krina T ZondervanNuffield Department of Obstetrics and Gynaecology, University of Oxford, Women's Centre, John Radcliffe Hospital, Oxford, UK.
Christian M BeckerNuffield Department of Obstetrics and Gynaecology, University of Oxford, Women's Centre, John Radcliffe Hospital, Oxford, UK.
Katy VincentNuffield Department of Obstetrics and Gynaecology, University of Oxford, Women's Centre, John Radcliffe Hospital, Oxford, UK.
University of Oxford · GBJohn Radcliffe Hospital · GB

Funding

Medical Research Council G0601458Medical Research Council MR/K011480/1Wellcome Trust 085235
6 · The paper itself

Abstract

backgroundChronic pelvic pain (CPP) is a significant public health problem with 1 million affected women in the UK. Although many pathologies are associated with CPP, the pain experienced is often disproportionate to the extent of disease identified and frequently no pathology is found (chronic pelvic pain syndrome). The central nervous system (CNS) is central to the experience of pain and chronic pain conditions in general are associated with alterations in both the structure and function of the CNS. This review describes the available evidence for central changes in association with conditions presenting with CPP.

methodsA detailed literature search was performed to identify relevant papers, however, this is not a systematic review.

resultsCPP is associated with central changes similar to those identified in other pain conditions. Specifically these include, alterations in the behavioural and central response to noxious stimulation, changes in brain structure (both increases and decreases in the volume of specific brain regions), altered activity of both the hypothalamic-pituitary-adrenal axis and the autonomic nervous system (ANS) and psychological distress.

conclusionsThe evidence reviewed in this paper demonstrates that CPP is associated with significant central changes when compared with healthy pain-free women. Moreover, the presence of these changes has the potential to both exacerbate symptoms and to predispose these women to the development of additional chronic conditions. These findings support the use of adjunctive medication targeting the CNS in these women.

Indexed as

BrainChronic PainEndometriosisFemaleHumansHypothalamo-Hypophyseal SystemPelvic PainPituitary-Adrenal SystemStress, Psychologicalcentral nervous systemchronic pelvic painendometriosisneuroimaging

Identifiers

PMID24920437
PMCPMC4501205
OpenAlexW2136897269

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.