ArticleeLife2014
Hidden synaptic differences in a neural circuit underlie differential behavioral susceptibility to a neural injury.
Article in eLife, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Article
- Article
- Degeneracy in epilepsy: multiple routes to hyperexcitable brain circuits and their repair.Communications biology · 2023Review
- Repeated applications of high potassium elicit long-term changes in a motor circuit from the crab,iScience · 2022Article
- Bursting emerges from the complementary roles of neurons in a four-cell network.Journal of neurophysiology · 2022Article
- The Consistency of Gastropod Identified Neurons Distinguishes Intra-Individual Plasticity From Inter-Individual Variability in Neural Circuits.Frontiers in behavioral neuroscience · 2022Review
- Circuit Stability to Perturbations Reveals Hidden Variability in the Balance of Intrinsic and Synaptic Conductances.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Using dynamic clamp to quantify pathological changes in the excitability of primary somatosensory neurons.The Journal of physiology · 2018Article
- Variations on a theme: species differences in synaptic connectivity do not predict central pattern generator activity.Journal of neurophysiology · 2017Article
- Sloppy morphological tuning in identified neurons of the crustacean stomatogastric ganglion.eLife · 2017Article
- When complex neuronal structures may not matter.eLife · 2017Article
- Control strategies of 3-cell Central Pattern Generator via global stimuli.Scientific reports · 2016Article
- Phylogenetic and individual variation in gastropod central pattern generators.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2015Review
- Consequences of acute and long-term removal of neuromodulatory input on the episodic gastric rhythm of the crab Cancer borealis.Journal of neurophysiology · 2015Article
- Compensatory plasticity restores locomotion after chronic removal of descending projections.Journal of neurophysiology · 2015Article
- Neuronal control of locomotor handedness in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Robust circuit rhythms in small circuits arise from variable circuit components and mechanisms.Current opinion in neurobiology · 2015Review
- Animal models in epilepsy research: legacies and new directions.Nature neuroscience · 2015Review
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Individuals vary in their responses to stroke and trauma, hampering predictions of outcomes. One reason might be that neural circuits contain hidden variability that becomes relevant only when those individuals are challenged by injury. We found that in the mollusc, Tritonia diomedea, subtle differences between animals within the neural circuit underlying swimming behavior had no behavioral relevance under normal conditions but caused differential vulnerability of the behavior to a particular brain lesion. The extent of motor impairment correlated with the site of spike initiation in a specific neuron in the neural circuit, which was determined by the strength of an inhibitory synapse onto this neuron. Artificially increasing or decreasing this inhibitory synaptic conductance with dynamic clamp correspondingly altered the extent of motor impairment by the lesion without affecting normal operation. The results suggest that neural circuit differences could serve as hidden phenotypes for predicting the behavioral outcome of neural damage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.