ReviewGenesis (New York, N.Y. : 2000)2014
Using zebrafish to study podocyte genesis during kidney development and regeneration.
Review in Genesis (New York, N.Y. : 2000), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 49 citations in OpenAlex.
- INHAND: Non-proliferative and proliferative lesions of fish - Chapter 15. Fish urinary system.Journal of toxicologic pathology · 2026Article
- Zebrafish as a model for human epithelial pathology.Laboratory animal research · 2025Review
- (Zebra)fishing for nephrogenesis genes.Tissue barriers · 2024Review
- Perturbations in podocyte transcriptome and biological pathways induced by FSGS associated circulating factors.Annals of translational medicine · 2023Article
- Principles of Zebrafish Nephron Segment Development.Journal of developmental biology · 2023Review
- Modeling Podocyte Ontogeny and Podocytopathies with the Zebrafish.Journal of developmental biology · 2023Review
- Advances in Understanding the Genetic Mechanisms of Zebrafish Renal Multiciliated Cell Development.Journal of developmental biology · 2022Review
- Article
- Automated in vivo compound screening with zebrafish and the discovery and validation of PD 81,723 as a novel angiogenesis inhibitor.Scientific reports · 2022Article
- Renal and Extra Renal Manifestations in Adult Zebrafish Model of Cystinosis.International journal of molecular sciences · 2021Article
- The Dynamics of Metabolic Characterization in iPSC-Derived Kidney Organoid DifferentiationFrontiers in genetics · 2021Article
- Application of zebrafish to safety evaluation in drug discovery.Journal of toxicologic pathology · 2020Review
- Advances in understanding vertebrate nephrogenesis.Tissue barriers · 2020Article
- Regeneration enhancers: A clue to reactivation of developmental genes.Development, growth & differentiation · 2020Review
- Prostaglandin signaling regulates renal multiciliated cell specification and maturation.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Iroquois transcription factor irx2a is required for multiciliated and transporter cell fate decisions during zebrafish pronephros development.Scientific reports · 2019Article
- Mechanisms of Nephrogenesis Revealed by Zebrafish Chemical Screen: Prostaglandin Signaling Modulates Nephron Progenitor Fate.Nephron · 2019Review
- Homeogene emx1 is required for nephron distal segment development in zebrafish.Scientific reports · 2018Article
- Article
- Pericytes in the renal vasculature: roles in health and disease.Nature reviews. Nephrology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
During development, vertebrates form a progression of up to three different kidneys that are comprised of functional units termed nephrons. Nephron composition is highly conserved across species, and an increasing appreciation of the similarities between zebrafish and mammalian nephron cell types has positioned the zebrafish as a relevant genetic system for nephrogenesis studies. A key component of the nephron blood filter is a specialized epithelial cell known as the podocyte. Podocyte research is of the utmost importance as a vast majority of renal diseases initiate with the dysfunction or loss of podocytes, resulting in a condition known as proteinuria that causes nephron degeneration and eventually leads to kidney failure. Understanding how podocytes develop during organogenesis may elucidate new ways to promote nephron health by stimulating podocyte replacement in kidney disease patients. In this review, we discuss how the zebrafish model can be used to study kidney development, and how zebrafish research has provided new insights into podocyte lineage specification and differentiation. Further, we discuss the recent discovery of podocyte regeneration in adult zebrafish, and explore how continued basic research using zebrafish can provide important knowledge about podocyte genesis in embryonic and adult environments. genesis 52:771-792, 2014. © 2014 Wiley Periodicals, Inc.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.