ArticleJournal of neurophysiology2014
Vibration of the organ of Corti within the cochlear apex in mice.
Article in Journal of neurophysiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 103 citations in OpenAlex.
- Broadband amplification of organ of Corti vibrations in the mouse cochlear apex.bioRxiv : the preprint server for biology · 2026Article
- The impulse response of the organ of Corti at the apex of the intact cochlea.Scientific reports · 2025Article
- Optical coherence tomography-based cochlear endoscopy through the human round window membrane.Optics letters · 2025Article
- Visualization of relative cochlear motions using high resolution optical coherence microscopy.Hearing research · 2025Article
- Visualizing motions within the cochlea's organ of Corti and illuminating cochlear mechanics with optical coherence tomography.Hearing research · 2025Review
- Tuning and Timing of Organ of Corti Vibrations at the Apex of the Intact Chinchilla Cochlea.Journal of the Association for Research in Otolaryngology : JARO · 2024Article
- Endolymphatic hydrops and cochlear synaptopathy after noise exposure are distinct sequelae of hair cell stereociliary bundle trauma.Scientific reports · 2024Article
- The spatial buildup of nonlinear compression in the cochlea.Frontiers in cellular neuroscience · 2024Article
- Compressed sensing on displacement signals measured with optical coherence tomography.Biomedical optics express · 2023Article
- Linear mixed-effect modeling of organ of Corti vibratory tuning curves.Hearing research · 2023Article
- On the Tonotopy of the Low-Frequency Region of the Cochlea.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The Remarkable Outer Hair Cell: Proceedings of a Symposium in Honour of W. E. Brownell.Journal of the Association for Research in Otolaryngology : JARO · 2023Review
- Estimating cochlear impulse responses using frequency sweeps.The Journal of the Acoustical Society of America · 2023Article
- Reconstruction of transverse-longitudinal vibrations in the organ of Corti complex via optical coherence tomography.The Journal of the Acoustical Society of America · 2023Article
- Alternative splicing in shaping the molecular landscape of the cochlea.Frontiers in cell and developmental biology · 2023Review
- Cochlear Amplification in the Short-Wave Region by Outer Hair Cells changing Organ-of-Corti area to Amplify the Fluid Traveling Wave.Hearing research · 2022Article
- The reticular lamina and basilar membrane vibrations in the transverse direction in the basal turn of the living gerbil cochlea.Scientific reports · 2022Article
- The impact of targeted ablation of one row of outer hair cells and Deiters' cells on cochlear amplification.Journal of neurophysiology · 2022Article
- Emerging Roles of RNA-Binding Proteins in Inner Ear Hair Cell Development and Regeneration.International journal of molecular sciences · 2022Review
- Overturning the mechanisms of cochlear amplification via area deformations of the organ of Corti.The Journal of the Acoustical Society of America · 2022Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
The tonotopic map of the mammalian cochlea is commonly thought to be determined by the passive mechanical properties of the basilar membrane. The other tissues and cells that make up the organ of Corti also have passive mechanical properties; however, their roles are less well understood. In addition, active forces produced by outer hair cells (OHCs) enhance the vibration of the basilar membrane, termed cochlear amplification. Here, we studied how these biomechanical components interact using optical coherence tomography, which permits vibratory measurements within tissue. We measured not only classical basilar membrane tuning curves, but also vibratory responses from the rest of the organ of Corti within the mouse cochlear apex in vivo. As expected, basilar membrane tuning was sharp in live mice and broad in dead mice. Interestingly, the vibratory response of the region lateral to the OHCs, the "lateral compartment," demonstrated frequency-dependent phase differences relative to the basilar membrane. This was sharply tuned in both live and dead mice. We then measured basilar membrane and lateral compartment vibration in transgenic mice with targeted alterations in cochlear mechanics. Prestin(499/499), Prestin(-/-), and Tecta(C1509G/C1509G) mice demonstrated no cochlear amplification but maintained the lateral compartment phase difference. In contrast, Sfswap(Tg/Tg) mice maintained cochlear amplification but did not demonstrate the lateral compartment phase difference. These data indicate that the organ of Corti has complex micromechanical vibratory characteristics, with passive, yet sharply tuned, vibratory characteristics associated with the supporting cells. These characteristics may tune OHC force generation to produce the sharp frequency selectivity of mammalian hearing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.